70 research outputs found
Predicting absolute sensitivity and limit of detection for x-ray analysis of pollution samples
Determination of soluble elements in water by x-ray fluorescence spectrometry after preconcentration with polyvinylpyrrolidone-thionalide
Interrater-Übereinstimmung und klinischer Nutzen der „Post-Ureteroscopic Lesion Scale“ (PULS) zur Graduierung von intraoperativen Harnleiterverletzungen einer Ureterorenoskopie
Background. The Post-ureteroscopic Lesion Scale (PULS) was designed as a standardized classification system for ureteral lesions after uretero(reno)scopy (URS). This study evaluates its routine use and a possible clinical impact based on a representative patient cohort. Materials and methods. Data of 307 patients in 14 German centers within the BUSTER project were used to test 3 hypotheses (H): PULS score shows a high interrater reliability (IRR) after independent assessment by urologic surgeon and assistance personnel (H1); PULS score is correlated with the frequency of postoperative complications during hospital stay (H2); post-URS stenting of the ureter is associated with higher PULS scores (H3). Results. Median age of patients was 54.4 years (interquartile range [IQR] 44.4-65.8; 65.5% male). Median diameter of index stones was 6mm (IQR 4-8) with 117 (38.4%) pyelocaliceal and 188 (61.6%) ureteral stones. Overall, 70 and 82.4% of patients had prestenting and post-URS stenting, respectively. Stone-free status was achieved in 68.7% after one URS procedure with a complication rate of 10.8% (mostly grade 1-2 according to Clavien-Dindo). PULS scores 0, 1, 2 and 3 were assessed in 40%, 52.1%, 6.9% and 1% of patients, respectively, when estimated by urologic surgeons. PULS score showed a high IRR between the urologic surgeon and assistance personnel (kappa = 0.883, p < 0.001), but was not significantly correlated with complications (rho = 0.09, p = 0.881). In contrast, a significant positive correlation was found between PULS score and post-URS stenting (rho = 0.287, p < 0.001). A PULS score of 1 multiplied the likelihood of post-URS stenting by 3.24 (95% confidence interval 1.43-7.34; p = 0.005) as opposed to PULS score 0. Conclusions. Removal of upper urinary tract stones using URS is safe and efficacious. Real-world data provided by this study confirm a high IRR of the PULS score and its clinical impact on the indication for post-URS stenting. A future prospective randomized trial should evaluate a possible standardization of post-URS stenting based on PULS score assessment
906 EVEN SOLITARY APICAL POSITIVE SURGICAL MARGINS ≤3 MM COMPROMISE ONCOLOGICAL OUTCOME FOLLOWING RADICAL PROSTATECTOMY: AN ANALYSIS OF MORE THAN 1000 PATIENTS BASED ON WHOLE MOUNT SECTIONS
Wertigkeit der H�moperfusion mit beschichteter Aktivkohle f�r die Behandlung schwerer Digitalis-Intoxikationen
Wie werden der 10-Punkte-Plan des Deutschen Bundesministeriums für Gesundheit zur Bekämpfung resistenter Erreger und Maßnahmen des Antibiotic Stewardship wahrgenommen?
Background. Due to increasing antibiotic resistances, relevant treatment problems are currently emerging in clinical practice. In March 2015, the German Federal Ministry of Health (BMG) published a 10-point plan designed to combat this development. Furthermore, the first German guideline on antibiotic stewardship (ABS) was implemented in 2013 and instructs physicians of different specialties about several treatment considerations. Evidence is scarce on how such concepts (10-point plan/BMG, ABS) are perceived among clinicians. Materials and methods. Within the MR2 study (Multiinstitutional Reconnaissance of practice with MultiResistant bacteria a survey focusing on German hospitals), a questionnaire including 4 + 35 items was sent to 18 German hospitals between August and October 2015, surveying internists, gyne-cologists, general surgeons, and urologists. Using multivariate logistic regression models (MLRM), the impact of medical specialty and further criteria on the endpoints (1) awareness of the 10-pointplan/BMG and (2) knowledge of ABSmeasures were assessed. Fulfillment of endpoints was predefined when average or full knowledge was reported (reference: poor to no knowledge). Results. Overall response rate was 43% (456/ 1061) for fully evaluable questionnaires. Only 63.0 and 53.6% of urologists and nonurologists (internists, gynecologists, and general surgeons), respectively, attended training courses regarding multidrugresistance or antibiotic prescribing in the 12 months prior to the study (P = 0.045). The endpoints average and full knowledge regarding 10-point plan/ BMG and ABS measures were fulfilled in only 31.4 and 32.8%, respectively. In MLRM, clinicians with at least one previous training course (reference: no training course) were 2.5-and 3.8-fold more likely to meet respective endpoint criteria (all P < 0.001). Medical specialty (urologists vs. nonurologists) did not significantly impact the endpoints in both MLRM. Conclusions. The 10-point plan/ BMG and ABS programs should be implemented into clinical practice, but awareness and knowledge of both is insufficient. Thus, it stands to reason that the actual realization of such measures is inadequate and continuous training towards rational prescription of antibiotics is necessary, regardless of medical specialty
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