Farmers' perceptions of the lay health worker on farms in the Western Cape, South Africa

This study is focussed on farms situated in the Boland health district of the Cape Winelands, South Africa. The aim was to explore, understand, and describe the perceptions of farmers of having a trained lay health worker (LHW) on the farm. A qualitative study design was applied. Data were collected during six in-depth interviews and two focus group discussions with participating farmers. The results show that farmers remained positive about the concept of having a trained LHW on the farm, but became frustrated with the lack of recognition of their and the LHWs' contribution by the public health service. Farmers who are willing to participate and remain active are key to introducing a farm community-based LHW intervention. Sustainable LHW interventions are dependent on public health sector support and recognition of all role players.Farm Management,

Application of quasi-Monte Carlo methods to PDEs with random coefficients -- an overview and tutorial

This article provides a high-level overview of some recent works on the application of quasi-Monte Carlo (QMC) methods to PDEs with random coefficients. It is based on an in-depth survey of a similar title by the same authors, with an accompanying software package which is also briefly discussed here. Embedded in this article is a step-by-step tutorial of the required analysis for the setting known as the uniform case with first order QMC rules. The aim of this article is to provide an easy entry point for QMC experts wanting to start research in this direction and for PDE analysts and practitioners wanting to tap into contemporary QMC theory and methods.Comment: arXiv admin note: text overlap with arXiv:1606.0661

Combining goal-oriented and model-driven approaches to solve the Payment Problem Scenario

Motivated by the objective to provide an improved participation of business domain experts in the design of service-oriented integration solutions, we extend our previous work on using the COSMO methodology for service mediation by introducing a goal-oriented approach to requirements engineering. With this approach, business requirements including the motivations behind the mediation solution are better understood, specified, and aligned with their technical implementations. We use the Payment Problem Scenario of the SWS Challenge to illustrate the extension

Locking Local Oscillator Phase to the Atomic Phase via Weak Measurement

We propose a new method to reduce the frequency noise of a Local Oscillator (LO) to the level of white phase noise by maintaining (not destroying by projective measurement) the coherence of the ensemble pseudo-spin of atoms over many measurement cycles. This scheme uses weak measurement to monitor the phase in Ramsey method and repeat the cycle without initialization of phase and we call, "atomic phase lock (APL)" in this paper. APL will achieve white phase noise as long as the noise accumulated during dead time and the decoherence are smaller than the measurement noise. A numerical simulation confirms that with APL, Allan deviation is averaged down at a maximum rate that is proportional to the inverse of total measurement time, tau^-1. In contrast, the current atomic clocks that use projection measurement suppress the noise only down to the level of white frequency, in which case Allan deviation scales as tau^-1/2. Faraday rotation is one of the possible ways to realize weak measurement for APL. We evaluate the strength of Faraday rotation with 171Yb+ ions trapped in a linear rf-trap and discuss the performance of APL. The main source of the decoherence is a spontaneous emission induced by the probe beam for Faraday rotation measurement. One can repeat the Faraday rotation measurement until the decoherence become comparable to the SNR of measurement. We estimate this number of cycles to be ~100 cycles for a realistic experimental parameter.Comment: 18 pages, 7 figures, submitted to New Journal of Physic

Correspondence Between DGP Brane Cosmology and 5D Ricci-flat Cosmology

We discuss the correspondence between the DGP brane cosmology and 5D Ricci-flat cosmology by letting their metrics equal each other. By this correspondence, a specific geometrical property of the arbitrary integral constant I in DGP metric is given and it is related to the curvature of 5D bulk. At the same time, the relation of arbitrary functions $\mu$ and $\nu$ in a class of Ricci-flat solutions is obtained from DGP brane metric.Comment: 8 pages, 1 figure, accepted by MPLA, added referenc

Hot new directions for quasi-Monte Carlo research in step with applications

This article provides an overview of some interfaces between the theory of quasi-Monte Carlo (QMC) methods and applications. We summarize three QMC theoretical settings: first order QMC methods in the unit cube $[0,1]^s$ and in $\mathbb{R}^s$, and higher order QMC methods in the unit cube. One important feature is that their error bounds can be independent of the dimension $s$ under appropriate conditions on the function spaces. Another important feature is that good parameters for these QMC methods can be obtained by fast efficient algorithms even when $s$ is large. We outline three different applications and explain how they can tap into the different QMC theory. We also discuss three cost saving strategies that can be combined with QMC in these applications. Many of these recent QMC theory and methods are developed not in isolation, but in close connection with applications

Adaptive Multidimensional Integration Based on Rank-1 Lattices

Quasi-Monte Carlo methods are used for numerically integrating multivariate functions. However, the error bounds for these methods typically rely on a priori knowledge of some semi-norm of the integrand, not on the sampled function values. In this article, we propose an error bound based on the discrete Fourier coefficients of the integrand. If these Fourier coefficients decay more quickly, the integrand has less fine scale structure, and the accuracy is higher. We focus on rank-1 lattices because they are a commonly used quasi-Monte Carlo design and because their algebraic structure facilitates an error analysis based on a Fourier decomposition of the integrand. This leads to a guaranteed adaptive cubature algorithm with computational cost $O(mb^m)$, where $b$ is some fixed prime number and $b^m$ is the number of data points

A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher PD

Laser frequency stabilization to a single ion

A fundamental limit to the stability of a single-ion optical frequency standard is set by quantum noise in the measurement of the internal state of the ion. We discuss how the interrogation sequence and the processing of the atomic resonance signal can be optimized in order to obtain the highest possible stability under realistic experimental conditions. A servo algorithm is presented that stabilizes a laser frequency to the single-ion signal and that eliminates errors due to laser frequency drift. Numerical simulations of the servo characteristics are compared to experimental data from a frequency comparison of two single-ion standards based on a transition at 688 THz in 171Yb+. Experimentally, an instability sigma_y(100 s)=9*10^{-16} is obtained in the frequency difference between both standards.Comment: 15 pages, 5 figures, submitted to J. Phys.

Kinetic Characterization and X-ray Structure of a Mutant of Haloalkane Dehalogenase with Higher Catalytic Activity and Modified Substrate Range

Conversion of halogenated aliphatics by haloalkane dehalogenase proceeds via the formation of a covalent alkyl-enzyme intermediate which is subsequently hydrolyzed by water. In the wild type enzyme, the slowest step for both 1,2-dichloroethane and 1,2-dibromoethane conversion is a unimolecular enzyme isomerization preceding rapid halide dissociation. Phenylalanine 172 is located in a helix-loop-helix structure that covers the active site cavity of the enzyme, interacts with the Clβ of 1,2-dichloroethane during catalysis, and could be involved in stabilization of this helix-loop-helix region of the cap domain of the enzyme. To obtain more information about the role of this residue in dehalogenase function, we performed a mutational analysis of position 172 and studied the kinetics and X-ray structure of the Phe172Trp enzyme. The Phe172Trp mutant had a 10-fold higher kcat/Km for 1-chlorohexane and a 2-fold higher kcat for 1,2-dibromoethane than the wild-type enzyme. The X-ray structure of the Phe172Trp enzyme showed a local conformational change in the helix-loop-helix region that covers the active site. This could explain the elevated activity for 1-chlorohexane of the Phe172Trp enzyme, since it allows this large substrate to bind more easily in the active site cavity. Pre-steady-state kinetic analysis showed that the increase in kcat found for 1,2-dibromoethane conversion could be attributed to an increase in the rate of an enzyme isomerization step that preceeds halide release. The observed conformational difference between the helix-loop-helix structures of the wild-type enzyme and the faster mutant suggests that the isomerization required for halide release could be a conformational change that takes place in this region of the cap domain of the dehalogenase. It is proposed that Phe172 is involved in stabilization of the helix-loop-helix structure that covers the active site of the enzyme and creates a rigid hydrophobic cavity for small apolar halogenated alkanes.