Otodental syndrome

The otodental syndrome also named otodental dysplasia, is characterised by a striking dental phenotype known as globodontia, associated with sensorineural high frequency hearing loss and eye coloboma. Globodontia occurs in both primary and permanent dentition, affecting canine and molar teeth (i.e. enlarged bulbous malformed posterior teeth with almost no discernable cusps or grooves). The condition appears to be inherited in an autosomal dominant mode, although sporadic cases have been reported. It is a rare disease, a few families have been described in the literature. In the British family, the locus for oculo-oto-dental syndrome was mapped to 20q13.1 within a 12-cM critical chromosomal region. Dental management is complex, interdisciplinary and will include regular follow up, scheduled teeth extraction and orthodontic treatment. Hearing checks and, if necessary, hearing aids are mandatory, as well as eye examination and ad hoc treatment if necessary

Stability and in vitro activity of nystatin and its γ-cyclodextrin complex against Candida albicans

gamma-Cyclodextrin (gamma-CD) was found to form an inclusion complex with nystatin. In the presence of gamma-CD, cells of Candida albicans absorbed less nystatin than in its absence. The gamma-CD/nystatin complex had no or insignificant antimicrobial activity. Upon diffusion into a gamma-CD-free medium the antibiotic was released from the complex and inhibited growth of the test organism. The stability of nystatin and the gamma-CD complex was studied using both a microbiological and a spectrophotometric assay. The stability of nystatin in aqueous preparations was improved by gamma-CD complexation. Degradation of pure nystatin did not follow first-order kinetics. The loss of antimycotic potency was more rapid than the decrease in concentration calculated from the spectrophotometric data for the pure antibiotic as well as its gamma-CD inclusion complex