Factory Gate Pricing: An Analysis of the Dutch Retail Distribution

Factory Gate Pricing (FGP) is a relatively new phenomenon in retail distribution. Under FGP, products are no longer delivered at the retailer distribution center, but collected by the retailer at the factory gates of the suppliers. Owing to both the asymmetry in the distribution networks (the supplier sites greatly outnumber the retailer distribution centers) and the better inventory and transport coordination mechanisms, this is likely to result in high savings. A mathematical model was used to analyze the benefits of FGP for a case study in the Dutch retail sector. Extensive numerical results are presented to show the effect of the orchestration shift from supplier to retailer, the improved coordination mechanisms, and sector-wide cooperation

Mining the Herschel-astrophysical terahertz large area survey : Submillimetre-selected blazars in equatorial fields

The Herschel-Astrophysical Terahertz Large Area Survey (H-ATLAS) provides an unprecedented opportunity to search for blazars at sub-mm wavelengths. We cross-matched the Faint Images of the Radio Sky at Twenty-cm (FIRST) radio source catalogue with the 11 655 sources brighter than 35 mJy at 500 μm in the ∼135 deg2 of the sky covered by the H-ATLAS equatorial fields at 9h and 15h, plus half of the field at 12h. We found that 379 of the H-ATLAS sources have a FIRST counterpart within 10 arcsec, including eight catalogued blazars (plus one known blazar that was found at the edge of one of the H-ATLAS maps). To search for additional blazar candidates we have devised new diagnostic diagrams and found that known blazars occupy a region of the log(S500μm/S350μm) versus log(S500μm/S1.4 GHz) plane separated from that of sub-mm sources with radio emission powered by star formation, but shared with radio galaxies and steep-spectrum radio quasars. Using this diagnostic we have selected 12 further possible candidates that turn out to be scattered in the (r-z) versus (u-r) plane or in the Wide-Field Infrared Survey Explorer colour-colour diagram, where known blazars are concentrated in well defined strips. This suggests that the majority of them are not blazars. Based on an inspection of all the available photometric data, including unpublished VISTA Kilo-degree Infrared Galaxy survey photometry and new radio observations, we found that the spectral energy distributions (SEDs) of only one out of the 12 newly selected sources are compatible with being synchrotron dominated at least up to 500 μm, i.e. with being a blazar. Another object may consist of a faint blazar nucleus inside a bright star-forming galaxy. The possibility that some blazar hosts are endowed with active star formation is supported by our analysis of the SEDs of Planck Early Release Compact Source Catalogue blazars detected at both 545 and 857 GHz. The estimated rest-frame synchrotron peak frequencies of H-ATLAS blazars are in the range 11.5 ≤ log (νpeak, Hz) ≤ 13.7, implying that these objects are low synchrotron peak. Six of them also show evidence of an ultraviolet excess that can be attributed to emission from the accretion disc. Allowing for the possibility of misidentifications and of contamination of the 500 μm flux density by the dusty torus or by the host galaxy, we estimate that there are seven or eight pure synchrotron sources brighter than S500μm = 35 mJy over the studied area, a result that sets important constraints on blazar evolutionary models.Peer reviewe

Molecular Targets for 17α-Ethynyl-5-Androstene-3β,7β,17β-Triol, an Anti-Inflammatory Agent Derived from the Human Metabolome

HE3286, 17α-ethynyl-5-androstene-3β, 7β, 17β-triol, is a novel synthetic compound related to the endogenous sterol 5-androstene-3β, 7β, 17β-triol (β-AET), a metabolite of the abundant adrenal steroid dehydroepiandrosterone (DHEA). HE3286 has shown efficacy in clinical studies in impaired glucose tolerance and type 2 diabetes, and in vivo models of types 1 and 2 diabetes, autoimmunity, and inflammation. Proteomic analysis of solid-phase HE3286-bound bead affinity experiments, using extracts from RAW 264.7 mouse macrophage cells, identified 26 binding partners. Network analysis revealed associations of these HE3286 target proteins with nodes in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for type 2 diabetes, insulin, adipokine, and adipocyte signaling. Binding partners included low density lipoprotein receptor-related protein (Lrp1), an endocytic receptor; mitogen activated protein kinases 1 and 3 (Mapk1, Mapk3), protein kinases involved in inflammation signaling pathways; ribosomal protein S6 kinase alpha-3 (Rsp6ka3), an intracellular regulatory protein; sirtuin-2 (Sirt2); and 17β-hydroxysteroid dehydrogenase 1 (Hsd17β4), a sterol metabolizing enzyme

Herschel*-ATLAS: deep HST/WFC3 imaging of strongly lensed submillimetre galaxies

We report on deep near-infrared observations obtained with the Wide Field Camera-3 (WFC3) onboard the Hubble Space Telescope (HST) of the first five confirmed gravitational lensing events discovered by the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS). We succeed in disentangling the background galaxy from the lens to gain separate photometry of the two components. The HST data allow us to significantly improve on previous constraints of the mass in stars of the lensed galaxy and to perform accurate lens modelling of these systems, as described in the accompanying paper by Dye et al. We fit the spectral energy distributions of the background sources from near-IR to millimetre wavelengths and use the magnification factors estimated by Dye et al. to derive the intrinsic properties of the lensed galaxies. We find these galaxies to have star-formations rates (SFR) ∼ 400–2000 M⊙ yr−1, with ∼(6–25) × 1010 M⊙ of their baryonic mass already turned into stars. At these rates of star formation, all remaining molecular gas will be exhausted in less than ∼100 Myr, reaching a final mass in stars of a few 1011 M⊙. These galaxies are thus proto-ellipticals caught during their major episode of star formation, and observed at the peak epoch (z ∼ 1.5–3) of the cosmic star formation history of the Universe

Induction of lymphokine-activated killer activity in rat splenocyte cultures: The importance of 2-mercaptoethanol and indomethacin

The role of 2-mercaptoethanol and indomethacin in the induction of lymphokine-activated killer (LAK) activity by interleukin-2 (IL-2) in rat splenocyte cultures was investigated. Spleens from 4-month-old male rats of five different strains were tested. Splenocytes were cultured for 3-5 days in the presence of IL-2 (1000 U/ml) and LAK activity was assessed by 4-h51Cr release assays with P815 and YAC-1 cells as targets. LAK activity could be induced by IL-2 in splenocytes from all rat strains, but only when 2-mercaptoethanol was present in the culture medium. Optimal LAK activity was induced when the 2-mercaptoethanol concentration in splenocyte cultures was at least 5 μM. Different rat strains showed differences in levels of in vitro induction of LAK activity. In the presence of 2-mercaptoethanol the level of LAK activity induced by IL-2 was high in BN and Lewis rats, intermediate in Wistar and Wag rats, and low in DZB rats. In the absence of 2-mercaptoethanol no or minimal LAK activity was induced. Furthermore we observed that addition of 50 μm indomethacin to the culture medium in the presence of 2-mercaptoethanol augmented the induction of LAK activity to some extent. In the absence of 2-mercaptoethanol, addition of indomethacin resulted only in low levels or no induction of LAK activity. We conclude that for optimal induction of LAK activity by IL-2 in rat splenocyte cultures 2-mercaptoethanol is essential, while indomethacin can only marginally further improve this induction

Herschel-ATLAS: towards a sample of ~1000 strongly-lensed galaxies

While the selection of strongly lensed galaxies with 500{\mu}m flux density S_500>100 mJy has proven to be rather straightforward (Negrello et al. 2010), for many applications it is important to analyze samples larger than the ones obtained when confining ourselves to such a bright limit. Moreover, only by probing to fainter flux densities is possible to exploit strong lensing to investigate the bulk of the high-z star-forming galaxy population. We describe HALOS (the Herschel-ATLAS Lensed Objects Selection), a method for efficiently selecting fainter candidate strongly lensed galaxies, reaching a surface density of ~1.5-2 deg^-2, i.e. a factor of about 4 to 6 higher than that at the 100 mJy flux limit. HALOS will allow the selection of up to ~1000 candidate strongly lensed galaxies (with amplifications \mu>2) over the full H-ATLAS survey area. Applying HALOS to the H-ATLAS Science Demonstration Phase field (~14.4 deg^2) we find 31 candidate strongly lensed galaxies, whose candidate lenses are identified in the VIKING near-infrared catalog. Using the available information on candidate sources and candidate lenses we tentatively estimate a ~72% purity of the sample. The redshift distribution of the candidate lensed sources is close to that reported for most previous surveys for lensed galaxies, while that of candidate lenses extends to substantially higher redshifts than found in the other surveys. The counts of candidate strongly lensed galaxies are also in good agreement with model predictions (Lapi et al. 2011). Even though a key ingredient of the method is the deep near-infrared VIKING photometry, we show that H-ATLAS data alone allow the selection of a similarly deep sample of candidate strongly lensed galaxies with an efficiency close to 50%; a slightly lower surface density (~1.45 deg^-2) can be reached with a ~70% efficiency.Comment: 36 pages, 12 figures, 1 table. Accepted by Ap