IN VITRO STUDY ON PROTEASE AND THROMBOLYTIC ACTIVITY OF AQUEOUS EXTRACT FROM LEUCAS ASPERA (L.) LEAVES

Objective: The current study is an attempt to screen for the in vitro clot lysis and proteolytic activity of aqueous extract of Leucas aspera leaves. Methods: Thrombolytic activity and protease activity of the crude enzyme obtained by ammonium sulfate precipitation and dialysis were assayed using blood clot and casein as substrates respectively. Native PAGE and gel documentation studies were performed to calculate the molecular weight of the enzyme. Results: In the study, 40% salt fractioned crude enzyme sample exhibited significant thrombolytic and caseinolytic activity. Further dose-dependent increased activity was observed with the maximum lytic activity of 52.11±1.04 % at 1 mg/ml of the sample when compared to the reference drug streptokinase (71.39±0.32%). Also, 68.72±0.62 U/hr of caseinolytic activity was observed for 1 mg/ml of the sample fraction. Conclusion: The study highlights and validates the efficacy of Leucas aspera leaves extract for thrombolytic and proteolytic actions. Enzyme with an approximate molecular weight, 19.89 KDa could be responsible for the significant lytic activity

The Rest-Frame UV Luminosity Density of Star-Forming Galaxies at Redshifts z>3.5

We have measured the rest--frame lambda~1500 Ang comoving specific luminosity density of star--forming galaxies at redshift 3.5<z<6.5 from deep images taken with the Hubble Space Telescope (HST)and the Advanced Camera for Surveys (ACS), obtained as part of the Great Observatories Origins Deep Survey (GOODS). We used color selection criteria to construct samples of star--forming galaxies at redshifts z~4, 5 and 6, identified by the signature of the 912 Ang Lyman continuum discontinuity and Lyman-alpha forest blanketing in their rest--frame UV colors (Lyman--break galaxies). The ACS samples cover ~0.09 square degree, and are also relatively deep, reaching between 0.2 and 0.5 L_3^*, depending on the redshift, where $L_3^*$ is the characteristic UV luminosity of Lyman--break galaxies at z~3. The specific luminosity density of Lyman--break galaxies appears to be nearly constant with redshift from z~3 to z~6, although the measure at z~6 remains relatively uncertain, because it depends on the accurate estimate of the faint counts of the z~6 sample. If Lyman--break galaxies are fair tracers of the cosmic star formation activity, our results suggest that at z~6 the universe was already producing stars as vigorously as it did near its maximum several Gyr later, at 1<~z<~3. Thus, the onset of large--scale star formation in the universe is to be sought at around z~6 or higher, namely at less than ~7% of the current cosmic age.Comment: AAS LaTeX macros 4.0, 11 pages, 1 postscript figure. Accepted for publication in The Astrophysical Journal, Letter. Minor changes to the figure caption. The data and the GOODS-group papers can be found at http://www.stsci.edu/science/goods

Growth and reproductive parameters of bonnet monkey (Macaca radiata)

The present paper summarizes some of the important biological and physiological data recorded over a 30-year period on the biology of bonnet monkeys in captivity. Data on sexual maturity, menstrual cyclicity, general behaviour, endocrine profile, reproductive physiology, gestation, parturition, postpartum amenorrhoea in the female, and sexual maturity, hormone profile, and seasonal variation in sperm count of the male monkeys are presented. In addition to the biological values, weights of selected organs, vertebral and dental pattern are also presented. Menarche occurred at an age of 36±4 months and the first conception in the colony occurred at an age of 54±4 months. The average menstrual cycle length was 28±4.3 days. Majority of monkeys did not cycle regularly during March-June during which the temperature reached a peak. The pregnancy index of the colony was 80% with controlled breeding. The gestation period was 166±5 days with 6-7 months postpartum amenorrhoea. Males attained sexual maturity by the age of 6-7 years and exhibited the characteristic nocturnal surge of serum testosterone at this age and sperm concentration ranged from 116-799 millions/ejaculate

Prochlo: Strong Privacy for Analytics in the Crowd

The large-scale monitoring of computer users' software activities has become commonplace, e.g., for application telemetry, error reporting, or demographic profiling. This paper describes a principled systems architecture---Encode, Shuffle, Analyze (ESA)---for performing such monitoring with high utility while also protecting user privacy. The ESA design, and its Prochlo implementation, are informed by our practical experiences with an existing, large deployment of privacy-preserving software monitoring. (cont.; see the paper

Dust in the Host Galaxies of Supernovae

We present Spitzer/MIPS 24 micron observations of 50 supernova host galaxies at 0.1<z<1.7 in the Great Observatories Origins Deep Survey (GOODS) fields. We also discuss the detection of SN host galaxies in SCUBA/850 micron observations of GOODS-N and Spitzer/Infrared Spectrograph (IRS) 16 micron observations of GOODS-S. About 60% of the host galaxies of both Type Ia and core-collapse supernovae are detected at 24 microns, a detection rate which is a factor of 1.5 higher than the field galaxy population. Among the 24 micron detected hosts, 80% have far-infrared luminosities that are comparable to or greater than the optical luminosity indicating the presence of substantial amounts of dust in the hosts. The median bolometric luminosity of the Type Ia SN hosts is \~10^10.5 L_sun, very similar to that of core-collapse SN hosts. Using the high resolution Hubble/ACS data, we have studied the variation of rest-frame optical/ultraviolet colors within the 24 micron detected galaxies at z<1 to understand the origin of the dust emission. The 24 micron detected galaxies have average colors which are redder by ~0.1 mag than the 24 micron undetected hosts while the latter show greater scatter in internal colors. This suggests that a smooth distribution of dust is responsible for the observed mid- and far-infrared emission. 70% of supernovae that have been detected in the GOODS fields are located within the half-light radius of the hosts where dust obscuration effects are significant. Although the dust emission that we detect cannot be translated into a line of sight A_V, we suggest that the factor of 2-3 larger scatter in the peak B-V colors that is seen in the high-z Type Ia supernova sample relative to the low-z supernovae might be partially due to the dust that we detect in the hosts.Comment: 22 pages, 4 figures, 4 tables; ApJ 635, Dec 20, 2005 issu

CASE REPORT

Abstract A healthy, 35-year old, male patient reported with left-sided facial trauma and ipsilateral lower extremity injury following a road traffic accident. Two weeks later, he developed hyperesthesia, pain and loss of vision in the left eye. Ophthalmic evaluation revealed cornea haziness, a dilated and fixed pupil and tonometry revealed an intra-ocular pressure of 60mm Hg. Thus, secondary glaucoma was diagnosed. Without delay anti-edema measures consisting of mannitol, a carbonic anhydrase inhibitor (acetazolamide) and β-adrenergic antagonistic eye-drops (timolol) were instituted. Results: Within 24 hours, the intra-ocular pressure reduced to 28mm of Hg and his vision gradually improved. The patient thereafter was put on topical anti-glaucoma medication and topical steroids for two weeks following which the IOP returned to normalcy; no inflammatory signs were noted and his medications were gradually tapered. Conclusion: Health care professionals need to be aware of the possible occurrence of such emergencies in cases of facial trauma, especially those presenting with head injury. Because head injury can similarly present with unilateral head ache, vomiting and photophobia, such symptoms have to be differentiated from those observed in secondary glaucoma, clinically. This consequently would eliminate diagnostic ambiguity. Since glaucoma is a sight-threatening emergency, extreme vigilance for such signs and symptoms is deemed necessary for immediate referral and management. Keywords: Secondary glaucoma, facial trauma, orbital injuries Case report A healthy, 35-year old, male patient reported with left-sided facial trauma and ipsilateral lower extremity injury following a road traffic accident; the patient was conscious and oriented with no history of any other neurological deficit. Local examination revealed multiple, left-sided, facial lacerations with ipsilateral circumorbital edema/ ecchymosis and sub-conjunctival hemorrhage. Palpation elicited left infra-orbital tenderness; however, ophthalmic evaluation revealed no impairment in visual acquity, ocular motility and pupillary responses (direct and consensual). CT of face revealed an undisplaced left infra-orbital rim fracture and anterior (maxillary) sinus wall communition for which wound debridement and primary closure was done. MRI of left knee joint revealed an inter-condylar fracture of tibia for which open reduction and internal fixation of the fracture was done. An orbital chart was maintained over the next 72 hours to assess visual acuity and pupillary responses. After 2 weeks, the patient developed hyperesthesia, pain and sudden loss of vision in the left eye. Immediate ophthalmic evaluation revealed a hazy cornea; the pupil was fixed and dilated; and tonometry revealed an intra-ocular pressure of 60mm Hg. Ophthalmoscopy of the fundus revealed a deep anterior chamber with multiple sphincteral and choroidal tears involving the macula. In view of these findings, a condition of secondary glaucoma was diagnosed. Anti-edema measures consisting of mannitol, a carbonic anhydrase inhibito

Evolution and Impact of Bars over the Last Eight Billion Years: Early Results from GEMS

Bars drive the dynamical evolution of disk galaxies by redistributing mass and angular momentum, and they are ubiquitous in present-day spirals. Early studies of the Hubble Deep Field reported a dramatic decline in the rest-frame optical bar fraction f_opt to below 5% at redshifts z>0.7, implying that disks at these epochs are fundamentally different from present-day spirals. The GEMS bar project, based on ~8300 galaxies with HST-based morphologies and accurate redshifts over the range 0.2-1.1, aims at constraining the evolution and impact of bars over the last 8 Gyr. We present early results indicating that f_opt remains nearly constant at ~30% over the range z=0.2-1.1,corresponding to lookback times of ~2.5-8 Gyr. The bars detected at z>0.6 are primarily strong with ellipticities of 0.4-0.8. Remarkably, the bar fraction and range of bar sizes observed at z>0.6 appear to be comparable to the values measured in the local Universe for bars of corresponding strengths. Implications for bar evolution models are discussed.Comment: Submitted June 25, 2004. 10 pages 5 figures. To appear in Penetrating Bars through Masks of Cosmic Dust: The Hubble Tuning Fork Strikes a New Note, eds. D. Block, K. Freeman, R. Groess, I. Puerari, & E.K. Block (Dordrecht: Kluwer), in pres

Central Structural Parameters of Early-Type Galaxies as Viewed with HST/NICMOS

We present surface photometry for the central regions of a sample of 33 early-type (E, S0, and S0/a) galaxies observed at 1.6 microns (H band) using the Hubble Space Telescope (HST). We employ a new technique of two-dimensional fitting to extract quantitative parameters for the bulge light distribution and nuclear point sources, taking into consideration the effects of the point-spread function. Parameterizing the bulge profile with a ``Nuker'' law, we confirm that the central surface-brightness distributions largely fall into two categories, each of which correlates with the global properties of the galaxies. ``Core'' galaxies tend to be luminous ellipticals with boxy or pure elliptical isophotes, whereas ``power-law'' galaxies are preferentially lower luminosity systems with disky isophotes. Unlike most previous studies, however, we do not find a clear gap in the distribution of inner cusp slopes; several objects have inner cusp slopes (0.3 < gamma < 0.5) which straddle the regimes conventionally defined for core and power-law type galaxies. The nature of these intermediate objects is unclear. We draw attention to two objects in the sample which appear to be promising cases of galaxies with isothermal cores that are not the brightest members of a cluster. Unresolved nuclear point sources are found in about 50% of the sample galaxies, roughly independent of profile type, with magnitudes in the range m^{nuc}_H = 12.8 to 17.4 mag, which correspond to M_H^{nuc} = -12.8 to -18.4 mag. (Abridged)Comment: To appear in The Astronomical Journal. Latex, 24 pages and 17 JPEG image

Chapter 11 - Agriculture, forestry and other land use (AFOLU)

Agriculture, Forestry, and Other Land Use (AFOLU) plays a central role for food security and sustainable development. Plants take up carbon dioxide (CO2) from the atmosphere and nitrogen (N) from the soil when they grow, re-distributing it among different pools, including above and below-ground living biomass, dead residues, and soil organic matter. The CO2 and other non-CO2 greenhouse gases (GHG), largely methane (CH4) and nitrous oxide (N2O), are in turn released to the atmosphere by plant respiration, by decomposition of dead plant biomass and soil organic matter, and by combustion. Anthropogenic land-use activities (e.g., management of croplands, forests, grasslands, wetlands), and changes in land use / cover (e.g., conversion of forest lands and grasslands to cropland and pasture, afforestation) cause changes superimposed on these natural fluxes. AFOLU activities lead to both sources of CO2 (e.g., deforestation, peatland drainage) and sinks of CO2 (e.g., afforestation, management for soil carbon sequestration), and to non-CO2 emissions primarily from agriculture (e.g., CH4 from livestock and rice cultivation, N2O from manure storage and agricultural soils and biomass burning. The main mitigation options within AFOLU involve one or more of three strategies: reduction / prevention of emissions to the atmosphere by conserving existing carbon pools in soils or vegetation that would otherwise be lost or by reducing emissions of CH4 and N2O; sequestration - enhancing the uptake of carbon in terrestrial reservoirs, and thereby removing CO2 from the atmosphere; and reducing CO2 emissions by substitution of biological products for fossil fuels or energy-intensive products. Demand-side options (e.g., by lifestyle changes, reducing losses and wastes of food, changes in human diet, changes in wood consumption), though known to be difficult to implement, may also play a role. Land is the critical resource for the AFOLU sector and it provides food and fodder to feed the Earth's population of ~7 billion, and fibre and fuel for a variety of purposes. It provides livelihoods for billions of people worldwide. It is finite and provides a multitude of goods and ecosystem services that are fundamental to human well-being. Human economies and quality of life are directly dependent on the services and the resources provided by land. Figure 11.1 shows the many provisioning, regulating, cultural and supporting services provided by land, of which climate regulation is just one. Implementing mitigation options in the AFOLU sector may potentially affect other services provided by land in positive or negative ways. In the Intergovernmental Panel on Climate Change (IPCC) Second Assessment Report (SAR) and in the IPCC Fourth Assessment Report (AR4), agricultural and forestry mitigation were dealt with in separate chapters. In the IPCC Third Assessment Report (TAR), there were no separate sectoral chapters on either agriculture or forestry. In the IPCC Fifth Assessment Report (AR5), for the first time, the vast majority of the terrestrial land surface, comprising agriculture, forestry and other land use (AFOLU), is considered together in a single chapter, though settlements (which are important, with urban areas forecasted to triple in size from 2000 global extent by 2030), are dealt with in Chapter 12. This approach ensures that all land-based mitigation options can be considered together; it minimizes the risk of double counting or inconsistent treatment (e.g., different assumptions about available land) between different land categories, and allows the consideration of systemic feedbacks between mitigation options related to the land surface. Considering AFOLU in a single chapter allows phenomena common across land-use types, such as competition for land and water, co-benefits, adverse side-effects and interactions between mitigation and adaptation to be considered consistently. The complex nature of land presents a unique range of barriers and opportunities, and policies to promote mitigation in the AFOLU sector need to take account of this complexity. In this chapter, we consider the competing uses of land for mitigation and for providing other services. Unlike the chapters on agriculture and forestry in AR4, impacts of sourcing bioenergy from the AFOLU sector are considered explicitly in a dedicated appendix. Also new to this assessment is the explicit consideration of food / dietary demand-side options for GHG mitigation in the AFOLU sector, and some consideration of freshwater fisheries and aquaculture, which may compete with the agriculture and forestry sectors, mainly through their requirements for land and / or water, and indirectly, by providing fish and other products to the same markets as animal husbandry. This chapter deals with AFOLU in an integrated way with respect to the underlying scenario projections of population growth, economic growth, dietary change, land-use change (LUC), and cost of mitigation. We draw evidence from both "bottom-up" studies that estimate mitigation potentials at small scales or for individual options or technologies and then scale up, and multi-sectoral "top-down" studies that consider AFOLU as just one component of a total multi-sector system response. In this chapter, we provide updates on emissions trends and changes in drivers and pressures in the AFOLU sector, describe the practices available in the AFOLU sector, and provide refined estimates of mitigation costs and potentials for the AFOLU sector, by synthesising studies that have become available since AR4. We conclude the chapter by identifying gaps in knowledge and data, providing a selection of Frequently Asked Questions, and presenting an Appendix on bioenergy to update the IPCC Special Report on Renewable Energy Sources and Climate Change Mitigation (SRREN)