Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles

Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens. The allele specificities were identified by sequence analysis in comparison with published HLAB and -C sequences, by transfection experiments, and Southern and northern blot analysis using oligonucleotide probes. Comparison of the classical HLA-A, -B, and -C sequences reveals that allele-specific substitutions seem to be rare events. HLA-B51 codes only for one allelespecific residue: arginine at position 81 located on the cd helix, pointing toward the antigen binding site. HLA-B8 contains an acidic substitution in amino acid position 9 on the first central/3 sheet which might affect antigen binding capacity, perhaps in combination with the rare replacement at position 67 (F) on the Alpha-l helix. HLA-B8 shows greatest homology to HLA-Bw42, -Bw41, -B7, and -Bw60 antigens, all of which lack the conserved restriction sites Pst I at position 180 and Sac I at position 131. Both sites associated with amino acid replacements seem to be genetic markers of an evolutionary split of the HLA-B alleles, which is also observed in the leader sequences. HLA-Cw7 shows 98% sequence identity to the JY328 gene. In general, the HLA-C alleles display lower levels of variability in the highly polymorphic regions of the Alpha 1 and Alpha 2 domains, and have more distinct patterns of locusspecific residues in the transmembrane and cytoplasmic domains. Thus we propose a more recent origin for the HLA-C locus

Timing jitter in photon detection by straight superconducting nanowires: Effect of magnetic field and photon flux

We studied the effect of the external magnetic field and photon flux on timing jitter in photon detection by straight superconducting NbN nanowires. At two wavelengths 800 and 1560 nm, statistical distribution in the appearance time of the photon count exhibits Gaussian shape at small times and exponential tail at large times. The characteristic exponential time is larger for photons with smaller energy and increases with external magnetic field while variations in the Gaussian part of the distribution are less pronounced. Increasing photon flux drives the nanowire from quantum detection mode to the bolometric mode that averages out fluctuations of the total number of nonequilibrium electrons created by the photon and drastically reduces jitter. The difference between Gaussian parts of distributions for these two modes provides the measure for the electron-number fluctuations. Corresponding standard deviation increases with the photon energy. We show that the two-dimensional hot-spot detection model explains qualitatively the effect of magnetic field

Scientific, Technical and Economic Committee for Fisheries. Review of scientific advice for 2012 - Part 2 (STECF-11-09) - Corrigendum

This corrigendum should replace the corresponding sections in the Part 2 of the STECF Review of advice for 2012 (STECF 2011. Review of scientific advice for 2012 – Part 2. Publications Office of the European Union, Luxembourg, EUR 24897 EN, JRC66020)

Holographic detection of parity in atomic and molecular orbitals

We introduce a concise methodology to detect the parity of atomic and molecular orbitals based on photoelectron holography, which is more general than the existing schemes. It fully accounts for the Coulomb distortions of electron trajectories, does not require sculpted fields to retrieve phase information and, in principle, is applicable to a broad range of electron momenta. By comparatively measuring the differential photoelectron spectra from strong-field ionization of N 2 molecules and their companion atoms of Ar, some photoelectron holography patterns are found to be dephased for both targets. This is well reproduced by the full-dimensional time-dependent Schrödinger equation and the Coulomb quantum-orbit strong-field approximation (CQSFA) simulation. Using the CQSFA, we trace back our observations to different parities of the 3 p orbital of Ar and the highest-occupied molecular orbital of N 2 via interfering Coulomb-distorted quantum orbits carrying different initial phases. This method could in principle be used to extract bound-state phases from any holographic structure, with a wide range of potential applications in recollision physics and spectroscopy

Argonne National Laboratory Reports

Test data from an in-pile failure experiment of high-power LMFBR-type fuel pins in a simulated $3/s transient-overpower (TOP) accident are reported and analyzed. Major conclusions are that (1) a series of cladding ruptures during the 100-ms period preceding fuel release injected small bursts of fission gas into the flow stream; (2) gas release influenced subsequent cladding melting and fuel release (there were no measurable FCI's (fuel-coolant interactions), and all fuel motion observed by the hodoscope was very slow); (3) the predominant post-failure fuel motion appears to be radial swelling that left a spongy fuel crust on the holder wall; (4) less than 4 to 6 percent of the fuel moved axially out of the original fuel zone, and most of this froze within a 10-cm region above the original top of the fuel zone to form the outlet blockage. An inlet blockage approximately 1 cm long was formed and consisted of large interconnected void regions. Both blockages began just beyond the ends of the fuel pellets

Argonne National Laboratory Reports

The report summarizes and evaluates experiments conducted in the Transient Reactor Test Facility (TREAT) using the Mark-II loop facility. The tests discussed are of the E and H series. Detailed descriptions of test conditions and test results as of February 1974 are presented. Since all data have not been acquired on all experiments, this report must be considered interim in nature. Particular emphasis is placed on data relevant to Fast Test Reactor (FTR) safety-analysis efforts