Dual dynamics of promises, and waiting games around emerging nanotechnologies.

Newly emerging science and technologies (NEST) are shaped by dynamics of promises. There is a paradoxical effect: diffuse and open-ended promises are forceful in policy discourse, but may hinder the realisation of these promises. Innovation actors are reluctant to invest in concrete developments because the promises are open-ended, and eventual demand is not articulated. This is a structural issue, and leads to ‘waiting games’ in which actors are entangled. We show how the occurrence of waiting games is linked to dual dynamics of promises in two fields where nanotechnology offers an open-ended (‘umbrella’) promise: organic and large area electronics and nano-enabled drug delivery. Based on such understanding of dynamics, our scenario exercises explored strategies to overcome waiting game

Modulation of thermogenesis and metabolic health:a built environment perspective

\u3cp\u3eLifestyle interventions, obviating the increasing prevalence of the metabolic syndrome, generally focus on nutrition and physical activity. Environmental factors are hardly covered. Because we spend on average more that 90% of our time indoors, it is, however, relevant to address these factors. In the built environment, the attention has been limited to the (assessment and optimization of) building performance and occupant thermal comfort for a long time. Only recently well-being and health of building occupants are also considered to some extent, but actual metabolic health aspects are not generally covered. In this review, we draw attention to the potential of the commonly neglected lifestyle factor ‘indoor environment’. More specifically, we review current knowledge and the developments of new insights into the effects of ambient temperature, light and the interaction of the two on metabolic health. The literature shows that the effects of indoor environmental factors are important additional factors for a healthy lifestyle and have an impact on metabolic health.\u3c/p\u3

Metaphors in Nanomedicine: The Case of Targeted Drug Delivery

International audienceThe promises of nanotechnology have been framed by a variety of metaphors, that not only channel the attention of the public, orient the questions asked by researchers, and convey epistemic choices closely linked to ethical preferences. In particular, the image of the 'therapeutic missile' commonly used to present targeted drug delivery devices emphasizes precision, control, surveillance and efficiency. Such values are highly praised in the current context of crisis of pharmaceutical innovation where military metaphors foster a general mobilization of resources from multiple fields of cutting-edge research. The missile metaphor, reminiscent of Paul Ehrlich's 'magic bullet', has framed the problem in simple terms: how to deliver the right dose in the right place at the right moment? Chemists, physicists and engineers who design multi-functional devices operating in vitro can think in such terms, as long as the devices are not actually operating through the messy environment of the body. A close look at what has been done and what remains to be done suggests that the metaphor of the "therapeutic missile" is neither sufficient, nor even necessary. Recent developments in nanomedicine suggest that therapeutic efficacy cannot be obtained without negotiating with the biological milieu and taking advantage of what it affords. An 'oïkological' approach seems more appropriate, more heuristic and more promising than the popular missile. It is based on the view of organism as an oikos that has to be carefully managed. The dispositions of nanocapsules have to be coupled with the affordances of the environment. As it requires dealing with nanoparticles as relational entities (defined by their potential for interactions) rather than as stable substances (defined by intrinsic properties) this metaphor eventually might well change research priorities in nanotechnology in general

Context Matters: Promises and Concerns Regarding Nanotechnologies for Water and Food Applications

Expectations in the form of promises and concerns contribute to the sense-making and valuation of emerging nanotechnologies. They add up to what we call ‘de facto assessments’ of novel socio-technical options. We explore how de facto assessments of nanotechnologies differ in the application domains of water and food by examining promises and concerns, and their relations in scientific discourse. We suggest that domain characteristics such as prior experiences with emerging technologies, specific discursive repertoires and user-producer relationships, play a key role in framing expectations of nanotechnology-enabled options. The article concludes by suggesting that domain-specific discourses may lead to undesirable lock-ins into specific de facto assessments pre-structuring anticipatory strategies of actor

Personal lighting conditions to obtain more evidence in light effect studies

Research demonstrated a large variety regarding effects of light (e.g. health, performance, or comfort effects). Since human health is related to each individual separately, the lighting conditions around these individuals should be analysed individually as well. This paper provides, based on a literature study, an overview identifying the currently used methodologies for measuring lighting conditions in light effect studies. 22 eligible articles were analysed and this resulted in two overview tables regarding the light measurement methodologies. In 70% of the papers, no measurement details were reported. In addition, light measurements were often averaged over time (in 84% of the papers) or location level (in 32% of the papers) whereas it is recommended to use continuous personal lighting conditions when light effects are being investigated. Conclusions drawn in light effect studies based on personal lighting conditions may be more trusting and valuable to be used as input for an effect-driven lighting control system

Label it or ban it? Public perceptions of nano-food labels and propositions for banning nano-food applications

The future of nano-food largely hinges on public perceptions and willingness to accept this novel technology. The present study utilizes the scientific literacy model and psychometric paradigm as the key theoretical frameworks to examine the factors influencing public support for labeling and banning of nano-food in Singapore. Using data collected from a nationally representative survey of 1001 respondents, the findings demonstrated that attitudes toward technology, preference for natural product, science knowledge, and risk perception were found to substantially affect public support for both labeling and banning of nano-food. Conversely, attention to food safety news on traditional media and attention to nano-news on new media were only associated with public support for labeling of nano-food. Similarly, benefit perception was only significantly associated with public support for banning of nano-food. Theoretically, these findings support the growing body of literature that argues for the significant role played by predispositions, media use, science knowledge, and risk and benefit perceptions on attitude formation toward nano-food. It serves as the pioneering piece to address the aspect of banning in the field of nano-food. Practically, insights drawn from this study could aid relevant stakeholders in enlisting effecting strategies to convey the benefits of nano-food while mitigating the risk perceptions among the public.MOE (Min. of Education, S’pore)Accepted versio