8 research outputs found
Large bowel obstruction due to sesame seed bezoar: a case report
peer-reviewedWe report a case of a 79 year old man with a known benign anastomotic stricture presenting with
large bowel obstruction. At laparotomy the obstruction was found to be caused by a large sesame
seed bezoar. Seed bezoars are well known to cause impaction in the rectum but have never been
previously reported to cause large bowel obstruction. We recommend that patients with known
large bowel strictures should be advised not to eat seeds as this could ultimately lead to
obstruction, ischaemia or perforationPUBLISHEDpeer-reviewe
P.11.15 Recombinant human insulin-like growth factor-I (IGF-I) therapy in Duchenne Muscular Dystrophy (DMD): A 6-month prospective randomized controlled trial
Randomized trial of lung hyperinflation therapy in children with congenital muscular dystrophy
Obstructive sleep apnea syndrome and autonomic dysfunction in Duchenne muscular dystrophy
Sleep Disordered Breathing in Duchenne Muscular Dystrophy
This review aims to explain the inevitable imbalance between respiratory load, drive, and muscular force that occurs in the natural aging of Duchenne muscular dystrophy and that predisposes these patients to sleep disordered breathing (SDB). In DMD, SDB is characterized by oxygen desaturation, apneas, hypercapnia, and hypoventilation during sleep and ultimately develops into respiratory failure during wakefulness. It can be present in all age groups. Young patients risk obstructive apneas because of weight gain, secondary to progressive physical inactivity and prolonged corticosteroid therapy; older patients hypoventilate and desaturate because of respiratory muscle weakness, in particular the diaphragm. These conditions are further exacerbated during REM sleep, the phase of maximal muscle hypotonia during which the diaphragm has to provide most of the ventilation. Evidence is given to the daytime predictors of early symptoms of SDB, important indicators for the proper time to initiate mechanical ventilation