8 research outputs found
The pathogenesis of chronic inflammation and malignant transformation in the human upper airways, the role of beta-defensins, eNOS, cell proliferation and apoptosis
The surrounding environment contains
plenty of pathogens, which represent a danger of
infection. The simplest way for the pathological
microorganism to enter the organism is the upper
airways. Inflammation of the upper airways is among the
most common and frequent diseases. This category
includes nasal polyposis and chronic tonsillitis. In many
cases it is associated with disorders in relation to the
immune response. An inflammatory infiltration of
mononuclears, eosinophils, plasma and mast cells can be
found in the histological structure of the polypous as
well as tonsillar mucosa.
One aim of this study was to determine the
expression of beta-defensins and various proteins, with a
possible potential role in relation to the rise and
development of those changes. Another aim was to
determine the relationship between the inflammatory and
malignant processes in the tonsils.
The samples of nasal polyps were obtained during
clinically indicated endonasal surgery from patients
diagnosed with nasal polyposis (n=50). The samples of
tonsils were collected during surgery from patients
suffering from chronic tonsillitis (n=11) or tonsillar carcinoma (n=17). Immunohistochemical procedures for
the detection of human beta-defensin 1, 2, 3 (HBD-1, 2,
3), Ki- 67, endothelial nitric oxide synthase (eNOS) and
cleaved caspase 3 were performed on cryostate and
paraffin sections.
It was proven that HBD are secreted in fairly large
amounts in cases of chronic inflammation. Their
secretion during the malignant transformation is limited.
This is a very probable fact that plays a role in malignant
transformation in tonsillar tissue. The crucial role in the
development of chronic inflammation, and maybe that of malignant transformation, is played by eNOS and its
product NO molecule. eNOS and the NO molecule are
involved in cell cycle regulation, in the apoptotic
processes and cell proliferation, as well as in the
angiogenesis and vasculogenesis. Our result confirmed
that eNOS is presented in the tissues of the upper
airways in both chronic inflammation and carcinomatous
processes. Ki-67 and cleaved caspase 3 were used as
markers of cell proliferation and apoptosis
Vitória e Japira: novas cultivares de bananeira.
Novas cultivares de bananeira resistentes à Sigatoka-negra. Principais características das cultivares Vitória e Japira, comparadas com as cultivares Prata e Pacovan, segundo a média dos dados coletados no Espírito Santo, Bahia e Amazônia Ocidental.bitstream/item/176709/1/Fol3732.pd