Nonmonotonic behavior of resistance in a superconductor-Luttinger liquid junction

Transport through a superconductor-Luttinger liquid junction is considered. When the interaction in the Luttinger liquid is repulsive, the resistance of the junction with a sufficiently clean interface shows nonmonotonic temperature- or voltage-dependence due to the competition between the superconductivity and the repulsive interaction. The result is discussed in connection with recent experiments on single-wall carbon nanotubes in contact with superconducting leads.Comment: Revtex4, 2 eps figure files, slightly revised from an earlier version submitted to PRL on 2001.12.

Local Spin Susceptibility of the S=1/2 Kagome Lattice in ZnCu3(OD)6Cl2

We report single-crystal 2-D NMR investigation of the nearly ideal spin S=1/2 kagome lattice ZnCu3(OD)6Cl2. We successfully identify 2-D NMR signals originating from the nearest-neighbors of Cu2+ defects occupying Zn sites. From the 2-D Knight shift measurements, we demonstrate that weakly interacting Cu2+ spins at these defects cause the large Curie-Weiss enhancement toward T=0 commonly observed in the bulk susceptibility data. We estimate the intrinsic spin susceptibility of the kagome planes by subtracting defect contributions, and explore several scenarios.Comment: 4 figures; published in PR-B Rapid Communication

Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling

The Tcf/Lef family of transcription factors mediates the Wnt/��-catenin pathway that is involved in a wide range of biological processes, including vertebrate embryogenesis and diverse pathogenesis. Post-translational modifications, including phosphorylation, sumoylation and acetylation, are known to be important for the regulation of Tcf/Lef proteins. However, the importance of ubiquitination and ubiquitin-mediated regulatory mechanisms for Tcf/Lef activity are still unclear. Here, we newly show that ubiquitin C-terminal hydrolase 37 (Uch37), a deubiquitinase, interacts with Tcf7 (formerly named Tcf1) to activate Wnt signalling. Biochemical analyses demonstrated that deubiquitinating activity of Uch37 is not involved in Tcf7 protein stability but is required for the association of Tcf7 to target gene promoter in both Xenopus embryo and human liver cancer cells. In vivo analyses further revealed that Uch37 functions as a positive regulator of the Wnt/��-catenin pathway downstream of ��-catenin stabilization that is required for the expression of ventrolateral mesoderm genes during Xenopus gastrulation. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/��-catenin pathway. ? 2017 The Author(s).113Ysciescopu

Domain-mediated interactions for protein subfamily identification

Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as with various functional and physical interaction networks in individual species. In humans, DMI subfamily members are associated with similar diseases, including cancers, and are frequently co-associated with the same diseases. DMI information relates to the functional and evolutionary subdivisions of human kinases. In yeast, DMI subfamilies contain proteins with similar phenotypic outcomes from specific chemical treatments. Therefore, the systematic investigation here provides insights into the diverse functions of subfamilies derived from a protein family with a link-centric approach and suggests a useful resource for annotating the functions and phenotypic outcomes of proteins.11Ysciescopu

Development of an ex vivo model for the study of cerebrovascular function utilizing isolated mouse olfactory artery

OBJECTIVE: Cerebral vessels, such as intracerebral perforating arterioles isolated from rat brain, have been widely used as an ex vivo model to study the cerebrovascular function associated with cerebrovascular disorders and the therapeutic effects of various pharmacological agents. These perforating arterioles, however, have demonstrated differences in the vascular architecture and reactivity compared with a larger leptomeningeal artery which has been commonly implicated in cerebrovascular disease. In this study, therefore, we developed the method for studying cerebrovascular function utilizing the olfactory artery isolated from the mouse brain. METHODS: The olfactory artery (OA) was isolated from the C57/BL6 wild-type mouse brain. After removing connective tissues, one side of the isolated vessel segment (approximately -500 µm in length) was cannulated and the opposite end of the vessel was completely sealed while being viewed with an inverted microscope. After verifying the absence of pressure leakage, we examined the vascular reactivity to various vasoactive agents under the fixed intravascular pressure (60 mm Hg). RESULTS: We found that the isolated mouse OAs were able to constrict in response to vasoconstrictors, including KCl, phenylephrine, endothelin-1, and prostaglandin PGH(2). Moreover, this isolated vessel demonstrated vasodilation in a dose-dependent manner when vasodilatory agents, acetylcholine and bradykinin, were applied. CONCLUSION: Our findings suggest that the isolated olfactory artery would provide as a useful ex vivo model to study the molecular and cellular mechanisms of vascular function underlying cerebrovascular disorders and the direct effects of such disease-modifying pathways on cerebrovascular function utilizing pharmacological agents and genetically modified mouse models

Optimal Pricing Effect on Equilibrium Behaviors of Delay-Sensitive Users in Cognitive Radio Networks

This paper studies price-based spectrum access control in cognitive radio networks, which characterizes network operators' service provisions to delay-sensitive secondary users (SUs) via pricing strategies. Based on the two paradigms of shared-use and exclusive-use dynamic spectrum access (DSA), we examine three network scenarios corresponding to three types of secondary markets. In the first monopoly market with one operator using opportunistic shared-use DSA, we study the operator's pricing effect on the equilibrium behaviors of self-optimizing SUs in a queueing system. %This queue represents the congestion of the multiple SUs sharing the operator's single \ON-\OFF channel that models the primary users (PUs) traffic. We provide a queueing delay analysis with the general distributions of the SU service time and PU traffic using the renewal theory. In terms of SUs, we show that there exists a unique Nash equilibrium in a non-cooperative game where SUs are players employing individual optimal strategies. We also provide a sufficient condition and iterative algorithms for equilibrium convergence. In terms of operators, two pricing mechanisms are proposed with different goals: revenue maximization and social welfare maximization. In the second monopoly market, an operator exploiting exclusive-use DSA has many channels that will be allocated separately to each entering SU. We also analyze the pricing effect on the equilibrium behaviors of the SUs and the revenue-optimal and socially-optimal pricing strategies of the operator in this market. In the third duopoly market, we study a price competition between two operators employing shared-use and exclusive-use DSA, respectively, as a two-stage Stackelberg game. Using a backward induction method, we show that there exists a unique equilibrium for this game and investigate the equilibrium convergence.Comment: 30 pages, one column, double spac