4,183 research outputs found

    Challenges in Managing the New Diverse Labor Force

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    Among the purposes of this chapter is (1) to examine past and present statuses of demographic groups who earlier suffered discrimination in employment but who today are legally protected. Our purpose is then (2) to appraise the issue of perceptions of fairness and equality, and next (3) to discuss problems still existing in the labor market in achieving “equality” under the law. Finally (4) we will offer some proposals for meeting still existing shortcomings. Because space requirements prohibit a discussion of all these groups, we are focusing on two of the largest: women and African-Americans

    Can the Market Add and Subtract? Mispricing in Tech Stock Carve-Outs

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    Recent equity carve-outs in US technology stocks appear to violate a basic premise of financial theory: identical assets have identical prices. In our 1998-2000 sample, holders of a share of company A are expected to receive x shares of company B, but the price of A is less than x times the price of B. A prominent example involves 3Com and Palm. Arbitrage does not eliminate these blatant mispricing due to short sale constraints, so that B is overpriced but expensive or impossible to sell short. Evidence from options prices shows that shorting costs are extremely high, eliminating exploitable arbitrage opportunities.

    Chicken Quantitative Trait lLoci for Growth and Body Composition Associated with the Very Low Density Apolipoprotein-II Gene

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    Very low density apolipoprotein-II (apoVLDL-II) is a major constituent of very low density lipoprotein and is involved in lipid transportation in chickens. The current study was designed to investigate the associations of an apoVLDL-II gene polymorphism on chicken growth and body composition traits. The Iowa Growth and Composition Resource Population was established by crossing broiler sires with dams from 2 unrelated highly inbred lines (Leghorn and Fayoumi). The F1 birds were intercrossed, within dam line, to produce 2 related F2 populations. Body weight and body composition traits were measured in the F2 population. Primers for the 5\u27-flanking region in apoVLDL-II were designed from database chicken genomic sequence. Single nucleotide polymorphisms (SNP) between parental lines were detected by DNA sequencing, and PCR-RFLP methods were then developed to genotype SNP in the F2 population. There was no polymorphism in the 492 bp sequenced between broiler and Leghorn. The apoVLDL-II polymorphism between broiler and Fayoumi was associated with multiple traits of growth and body composition in the 148 male F2 individuals, including BW, breast muscle weight, drumstick weight, and tibia length. This research suggests that apoVLDL-II or a tightly linked gene has broad effects on growth and development in the chicken

    The Use of the Wave Guide for Dielectric Measurements

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    Abstract Not Provided

    Multidimensional measurement of exposure to music in childhood: Beyond the musician/ non-musician dichotomy

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    Much research in music psychology characterizes the music background of its participants in a dichotomous manner, labeling participants as “musicians” and “non-musicians” or professionals and non-professionals. However, this terminology is inconsistent from study to study, and even more sophisticated measures fail to accurately represent music experiences; moreover, there is no standardized measure suitable for use with younger participants. This article presents a new measure, the Exposure to Music in Childhood Inventory, for capturing the amount and type of exposure to music activities suitable for use with children. Children from public and private school, aged 5 to 13 years old (N = 1006; M = 8.36 years old, SD = 1.5 years) completed the inventory, and through a combination of exploratory and confirmatory factor analysis a two-factor solution was obtained. The first factor includes personal music listening activities, home musical environment and the influence of television and the internet; the second reflects more social, active and public elements of music-making, playing an instrument and performing. This scale is suitable for use in a wide range of future research to more accurately assess the kinds of music activities children have access to in a dimensional way, which can have a bearing on their understanding of musi

    Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy

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    BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease resulting from mutations in the survival motor neuron 1 (SMN1) gene. Recent breakthroughs in preclinical research have highlighted several potential novel therapies for SMA, increasing the need for robust and sensitive clinical trial platforms for evaluating their effectiveness in human patient cohorts. Given that most clinical trials for SMA are likely to involve young children, there is a need for validated molecular biomarkers to assist with monitoring disease progression and establishing the effectiveness of therapies being tested. Proteomics technologies have recently been highlighted as a potentially powerful tool for such biomarker discovery. METHODS: We utilized label-free proteomics to identify individual proteins in pathologically-affected skeletal muscle from SMA mice that report directly on disease status. Quantitative fluorescent western blotting was then used to assess whether protein biomarkers were robustly changed in muscle, skin and blood from another mouse model of SMA, as well as in a small cohort of human SMA patient muscle biopsies. RESULTS: By comparing the protein composition of skeletal muscle in SMA mice at a pre-symptomatic time-point with the muscle proteome at a late-symptomatic time-point we identified increased expression of both Calreticulin and GRP75/Mortalin as robust indicators of disease progression in SMA mice. We report that these protein biomarkers were consistently modified in different mouse models of SMA, as well as across multiple skeletal muscles, and were also measurable in skin biopsies. Furthermore, Calreticulin and GRP75/Mortalin were measurable in muscle biopsy samples from human SMA patients. CONCLUSIONS: We conclude that label-free proteomics technology provides a powerful platform for biomarker identification in SMA, revealing Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers capable of reporting on disease progression in samples of muscle and skin

    Sea turtle nesting activity along Eglin Air Force Base on Cape San Blas and Santa Rosa Island, Florida from 1994 to 1997.

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    Along EAFB on Cape San BIas, the only sea turtle species nest observed has been the loggerhead turtle. The first green turtle nest documented along the Florida panhandle coast was observed on EAFB property, however (D. Atencio, EAFB, pers. comm). Santa Rosa Island, located approximately 150 miles west of Cape San BIas supports a small but consistent, group of nesting green turtles (Fig. 2). Although erosion is not as severe along Santa Rosa Island as it is on Cape San BIas, and vehicular traffic is not permitted, sea turtles nesting on this barrier island must survive severe tropical storms, predation, and artificial lighting to be successful. Because this area supports a rare group of nesting green turtles and is disturbed by intense artificial lighting from Air Force missions and adjacent resort towns, continued monitoring is necessary. The sea turtle species that nest along this barrier island, and the human activities that disturb those sea turtles present unique circumstances for management ofthis area. Protection ofthe significant nesting populations of sea turtles on EAFB properties on Cape San BIas and Santa Rosa Island requires yearly monitoring of the nesting activity and the natural and human disturbances influencing the nesting females. The objectives ofthis study were to monitor sea turtle nesting along EAFB on Cape San BIas to determine number of nests and hatching success, assess disturbances, and determine proper management to ensure successful nesting and hatching.(56 page document
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