20 research outputs found
The association between expressed emotion, illness severity and subjective burden of care in relatives of patients with schizophrenia. Findings from an Italian population
Effects of thermal and enzymatic treatments and harvesting time on the microbial quality and chemical composition of fibre hemp (Cannabis sativa L.)
The Fate of Char Nitrogen in Black Liquor Combustion—Cyanate Formation and Decomposition
STUDIES ON THE THERMAL CONDUCTIVITY OF COMPOSITE MATERIALS BASED ON LOCAL RENEWABLE RESOURCES / KOMPOZICINIŲ TERMOIZOLIACINIŲ MEDŽIAGŲ IŠ VIETINIŲ ATSINAUJINANČIŲ IŠTEKLIŲ ŠILUMOS LAIDUMO TYRIMAI
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.
We explored adeno-associated viral vector (AAV)-mediated gene transfer in the perinatal period in animal models of severe congenital factor VII (FVII) deficiency, a disease associated with early postnatal life-threatening hemorrhage. In young adult mice with plasma FVII 1% by 7 weeks. Re-administration of an alternative serotype at 12 months postnatal age increased hFVII levels to 165% ± 6.2% of normal, which remained at therapeutic levels for a further 28 weeks without toxicity. Thus, perinatal AAV-mediated gene transfer shows promise for disorders with onset of pathology early after birth
LONG TERM PERINATAL GENE TRANSFER AFTER CLINICALLY APPLICABLE DELIVERY OF PRENATAL GENE THERAPY IN THE SHEEP
Are we there yet? The four-year impact of a VA fellowship program on the recovery orientation of rehabilitation programs.
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.
We explored adeno-associated viral vector (AAV)-mediated gene transfer in the perinatal period in animal models of severe congenital factor VII (FVII) deficiency, a disease associated with early postnatal life-threatening hemorrhage. In young adult mice with plasma FVII 1% by 7 weeks. Re-administration of an alternative serotype at 12 months postnatal age increased hFVII levels to 165% ± 6.2% of normal, which remained at therapeutic levels for a further 28 weeks without toxicity. Thus, perinatal AAV-mediated gene transfer shows promise for disorders with onset of pathology early after birth