Testing surface area with arbitrary accuracy

Recently, Kothari et al.\ gave an algorithm for testing the surface area of an arbitrary set $A \subset [0, 1]^n$. Specifically, they gave a randomized algorithm such that if $A$'s surface area is less than $S$ then the algorithm will accept with high probability, and if the algorithm accepts with high probability then there is some perturbation of $A$ with surface area at most $\kappa_n S$. Here, $\kappa_n$ is a dimension-dependent constant which is strictly larger than 1 if $n \ge 2$, and grows to $4/\pi$ as $n \to \infty$. We give an improved analysis of Kothari et al.'s algorithm. In doing so, we replace the constant $\kappa_n$ with $1 + \eta$ for $\eta > 0$ arbitrary. We also extend the algorithm to more general measures on Riemannian manifolds.Comment: 5 page

Use of OTSC Device System for Closure of Fistulas in the Alimentary Tract – A Case Series

AbstractObjectiveWe report our experience – a case series with the Over the Scope Clip (OTSC), Bear claw, a novel and new tool for the endoscopic entrapment of tissue for closure of fistula and perforations.DesignSingle-center.SettingTertiary referral academic gastroenterology unit and center for advanced therapeutic endoscopy.Patient Case I – referred for endoscopic treatment for the closure of gastrocutaneous fistula (GC).Case II – referred for endoscopic treatment for the closure of colo-vaginal fistula.Case III – referred for endoscopic treatment for the closure of GC fistula.InterventionThe OTSC system was mounted on the tip of the scope and passed down to the level of the fistula. The targeted site of the fistula was grasped with the tissue anchoring tripod and pulled into the cap with concomitant scope channel suction. Once the tissue was trapped in the cap, the Bear claw was deployed.Main outcome measurementsNA.ResultsAll patients recovered. No complication or recurrence noted. Case I showed successful results with closure of the fistula. Case II fistula was not closed due to the cavity beneath the fistula probably abscess formation – which prevented the healing of the fistula site despite of the closure with OTSC. Case III fistula did not close successfully due to the larger diameter of the fistula which was greater than 1 cm.ConclusionWith several new devices being introduced, it is difficult to judge the implementation of one tool over the others. This device has shown promising results for fistula closure if used knowing the limitation of the product

Intervention Development to Improve Foster Youth Mental Health by Targeting Coping Self-Efficacy and Help-seeking

This study articulates the iterative development of an intervention called Strengthening Youth Networks and Coping (SYNC), which is designed to target coping self-efficacy and help-seeking intentions and behaviors among youth in foster care. The overarching goal is to design an intervention that will be a feasible and acceptable enhancement to existing child welfare services, and that will address modifiable determinants among adolescents involved in child welfare system that are related to elevated risk for mental health challenges, limited support network capacity, and service disengagement after exiting foster care. In this paper, we describe our initial needs assessment, explain how we selected proximal intervention mechanisms (i.e., intermediate outcomes) to target, and outline the preliminary intervention development process, including ongoing insights we received from a research advisory group including members with lived experience. Next, we report and discuss the initial acceptability pre-testing data collected from youth (N=30) as well as feasibility data collected from providers (N=82), results from which were used to refine the SYNC intervention framework prior to robust efficacy testing. Findings highlight the need and importance of targeting youth coping and help-seeking, integrating programming within existing transition services, delivering this content in a group-based format that includes near-peer mentors and facilitators with lived experience, and developing options that work for the heterogeneous population of young people in foster care. The results also highlight the key objective of capturing youth’s interests prior to enrolling in the program (e.g., language used in recruitment materials), holding their interest throughout the program (e.g., creating opportunities for youth to engage with other youth with similar experiences), and suggestions to encourage youth’s engagement and participation. This paper articulates the value of this intervention development approach, and the sequential phases of this intervention development process as well as the results, which may be useful to applied researchers and practitioners working with youth in foster care and other priority populations

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia

BACKGROUND: Mutations in the three-prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL). However, the endogenous expression of TREX1 in human brain has not been studied. METHODS: We produced a rabbit polyclonal antibody (pAb) to TREX1 to characterize TREX1 by Western blotting (WB) of cell lysates from normal controls and subjects carrying an RVCL frame-shift mutation. Dual staining was performed to determine cell types expressing TREX1 in human brain tissue. TREX1 distribution in human brain was further evaluated by immunohistochemical analyses of formalin-fixed, paraffin-embedded samples from normal controls and patients with RVCL and ischemic stroke. RESULTS: After validating the specificity of our anti-TREX1 rabbit pAb, WB analysis was utilized to detect the endogenous wild-type and frame-shift mutant of TREX1 in cell lysates. Dual staining in human brain tissues from patients with RVCL and normal controls localized TREX1 to a subset of microglia and macrophages. Quantification of immunohistochemical staining of the cerebral cortex revealed that TREX1 CONCLUSIONS: TREX1 is expressed by a subset of microglia in normal human brain, often in close proximity to the microvasculature, and increases in the setting of ischemic lesions. These findings suggest a role for TREX

Study of clinical profile and outcome of patients with acute non-traumatic paraparesis

Background: The following study is about the clinical profile and outcome of patients with acute non traumatic paraparesis. It includes the aetiology, clinical presentation and the outcome of various cases of acute non traumatic paraparesis. Paraplegia or paraparesis could be defined as loss of function of both legs as a result of disease or injury of the spinal cord, spinal roots, peripheral nerves or myopathies. Acute non-traumatic paraparesis is a neurological emergency. Reversible causes of acute paraplegia can be treated successfully if diagnosed early.Methods: The observational study was done in the department of general medicine at D. Y. Patil Hospital, Navi Mumbai with sample size of 75 patients over 1 year.Results: With early diagnosis prognosis of acute non traumatic paraparesis can be improved which was evaluated over period of 3 months.Conclusions: Acute non-traumatic paraparesis is a neurological emergency. Reversible causes of acute paraplegia can be treated successfully if diagnosed early. It is important to diagnose and classify all cases into compressive and non-compressive lesions based on presenting symptoms because the management of the two differs