Localization of massive fermions on the baby-skyrmion branes in 6 dimensions

We construct brane solutions in 6 dimensional Einstein-Skyrme systems. A class of baby skyrmion solutions realizes warped compactification of the extra dimensions and gravity localization on the brane for negative bulk cosmological constant. Coupling of the fermions with the brane skyrmions lead to the brane localized fermions. In terms of the level crossing picture, emergence of the massive localized modes as well as the zero mode are observed. Nonlinear nature of the skyrmions brings richer information for the fermions level structure. The level comprises doubly degenerate lowest plus single excited modes. The three generation of the fundamental fermions is based on this structure. The quark/lepton mass hierarchy is successfully obtained in terms of a slightly deformed baby-skyrmions with topological charge three.Comment: 16 pages, 17 figures. One figure added, some points clarified, references improved. Version accepted for publicatio

Insect Pests Of Sorghum And Their Control

The insect pests that attack sorghum are presented. Crop damage is discussed in relation to pest species and plant part on which infestation occur namely, seedling, foliage, stem and panicle insects. The importance of the major species are discussed on a regional basis. Shootfly, midge, stem borers and head bugs in Africa and India; the greenbug and midge in the continental USA; midge, armyworm and greenbug in Central and South America and midge and Heliothis in Australia. A brief review of current control measures is given for each pest across regions highlighting differences between developed and developing countries. However, the more holistic pest management approach is applicable in all pest control situations and host plant resistance is seen as the major component required for mounting successful control strategies

Twisted and Nontwisted Bifurcations Induced by Diffusion

We discuss a diffusively perturbed predator-prey system. Freedman and Wolkowicz showed that the corresponding ODE can have a periodic solution that bifurcates from a homoclinic loop. When the diffusion coefficients are large, this solution represents a stable, spatially homogeneous time-periodic solution of the PDE. We show that when the diffusion coefficients become small, the spatially homogeneous periodic solution becomes unstable and bifurcates into spatially nonhomogeneous periodic solutions. The nature of the bifurcation is determined by the twistedness of an equilibrium/homoclinic bifurcation that occurs as the diffusion coefficients decrease. In the nontwisted case two spatially nonhomogeneous simple periodic solutions of equal period are generated, while in the twisted case a unique spatially nonhomogeneous double periodic solution is generated through period-doubling. Key Words: Reaction-diffusion equations; predator-prey systems; homoclinic bifurcations; periodic solutions.Comment: 42 pages in a tar.gz file. Use ``latex2e twisted.tex'' on the tex files. Hard copy of figures available on request from [email protected]

Localizing gravity on Maxwell gauged CP1 model in six dimensions

We shall consider about a 3-brane embedded in six-dimensional space-time with a negative bulk cosmological constant. The 3-brane is constructed by a topological soliton solution living in two-dimensional axially symmetric transverse subspace. Similar to most previous works of six-dimensional soliton models, our Maxwell gauged CP1 brane model can also achieve to localize gravity around the 3-brane. The CP1 field is described by a scalar doublet and derived from O(3) sigma model by projecting it onto two-dimensional complex space. In that sense, our framework is more effective than other solitonic brane models concerning with gauge theory. We shall also discuss about linear stability analysis for our new model by fluctuating all fields.Comment: 23 pages, 7 figures; references adde

Plasma Membrane Ca 2+-ATPase in Rat and Human Odontoblasts Mediates Dentin Mineralization

Intracellular Ca(2+) signaling engendered by Ca(2+) influx and mobilization in odontoblasts is critical for dentinogenesis induced by multiple stimuli at the dentin surface. Increased Ca(2+) is exported by the Na(+)–Ca(2+) exchanger (NCX) and plasma membrane Ca(2+)–ATPase (PMCA) to maintain Ca(2+) homeostasis. We previously demonstrated a functional coupling between Ca(2+) extrusion by NCX and its influx through transient receptor potential channels in odontoblasts. Although the presence of PMCA in odontoblasts has been previously described, steady-state levels of mRNA-encoding PMCA subtypes, pharmacological properties, and other cellular functions remain unclear. Thus, we investigated PMCA mRNA levels and their contribution to mineralization under physiological conditions. We also examined the role of PMCA in the Ca(2+) extrusion pathway during hypotonic and alkaline stimulation-induced increases in intracellular free Ca(2+) concentration ([Ca(2+)](i)). We performed RT-PCR and mineralization assays in human odontoblasts. [Ca(2+)](i) was measured using fura-2 fluorescence measurements in odontoblasts isolated from newborn Wistar rat incisor teeth and human odontoblasts. We detected mRNA encoding PMCA1–4 in human odontoblasts. The application of hypotonic or alkaline solutions transiently increased [Ca(2+)](i) in odontoblasts in both rat and human odontoblasts. The Ca(2+) extrusion efficiency during the hypotonic or alkaline solution-induced [Ca(2+)](i) increase was decreased by PMCA inhibitors in both cell types. Alizarin red and von Kossa staining showed that PMCA inhibition suppressed mineralization. In addition, alkaline stimulation (not hypotonic stimulation) to human odontoblasts upregulated the mRNA levels of dentin matrix protein-1 (DMP-1) and dentin sialophosphoprotein (DSPP). The PMCA inhibitor did not affect DMP-1 or DSPP mRNA levels at pH 7.4–8.8 and under isotonic and hypotonic conditions, respectively. We also observed PMCA1 immunoreactivity using immunofluorescence analysis. These findings indicate that PMCA participates in maintaining [Ca(2+)](i) homeostasis in odontoblasts by Ca(2+) extrusion following [Ca(2+)](i) elevation. In addition, PMCA participates in dentinogenesis by transporting Ca(2+) to the mineralizing front (which is independent of non-collagenous dentin matrix protein secretion) under physiological and pathological conditions following mechanical stimulation by hydrodynamic force inside dentinal tubules, or direct alkaline stimulation by the application of high-pH dental materials

Dynamics of the Universal Area-Preserving Map Associated with Period Doubling: Hyperbolic Sets

It is known that the famous Feigenbaum-Coullet-Tresser period doubling universality has a counterpart for area-preserving maps of {\fR}^2. A renormalization approach has been used in \cite{EKW1} and \cite{EKW2} in a computer-assisted proof of existence of a "universal" area-preserving map $F_*$ -- a map with orbits of all binary periods 2^k, k \in \fN. In this paper, we consider maps in some neighbourhood of $F_*$ and study their dynamics. We first demonstrate that the map $F_*$ admits a "bi-infinite heteroclinic tangle": a sequence of periodic points $\{z_k\}$, k \in \fZ, |z_k| \converge{{k \to \infty}} 0, \quad |z_k| \converge{{k \to -\infty}} \infty, whose stable and unstable manifolds intersect transversally; and, for any N \in \fN, a compact invariant set on which $F_*$ is homeomorphic to a topological Markov chain on the space of all two-sided sequences composed of $N$ symbols. A corollary of these results is the existence of {\it unbounded} and {\it oscillating} orbits. We also show that the third iterate for all maps close to $F_*$ admits a horseshoe. We use distortion tools to provide rigorous bounds on the Hausdorff dimension of the associated locally maximal invariant hyperbolic set: $$ 0.7673 \ge {\rm dim}_H(\cC_F) \ge \varepsilon \approx 0.00044 e^{-1797}.$

Three-dimensional coherent X-ray diffraction imaging of a ceramic nanofoam: determination of structural deformation mechanisms

Ultra-low density polymers, metals, and ceramic nanofoams are valued for their high strength-to-weight ratio, high surface area and insulating properties ascribed to their structural geometry. We obtain the labrynthine internal structure of a tantalum oxide nanofoam by X-ray diffractive imaging. Finite element analysis from the structure reveals mechanical properties consistent with bulk samples and with a diffusion limited cluster aggregation model, while excess mass on the nodes discounts the dangling fragments hypothesis of percolation theory.Comment: 8 pages, 5 figures, 30 reference

Bacterial artificial chromosomes as analytical basis for gene transcriptional machineries

Bacterial Artificial Chromosomes (BACs) had been minimal components of various genome-sequencing projects, constituting perfect analytical basis for functional genomics. Here we describe an enhancer screening strategy in which BAC clones that cover any genomic segments of interest are modified to harbor a reporter cassette by transposon tagging, then processed to carry selected combinations of gene regulatory modules by homologous recombination mediated systematic deletions. Such engineered BAC-reporter constructs in bacterial cells are ready for efficient transgenesis in mice to evaluate activities of gene regulatory modules intact or absent in the constructs. By utilizing the strategy, we could speedily identify a critical genomic fragment for spatio-temporally regulated expression of a mouse cadherin gene whose structure is extraordinarily huge and intricate. This BAC-based methodology would hence provide a novel screening platform for gene transcriptional machineries that dynamically fluctuate during development, pathogenesis and/or evolution

Application of layered poly (L-lactic acid) cell free scaffold in a rabbit rotator cuff defect model

<p>Abstract</p> <p>Background</p> <p>This study evaluated the application of a layered cell free poly (L-lactic acid) (PLLA) scaffold to regenerate an infraspinatus tendon defect in a rabbit model. We hypothesized that PLLA scaffold without cultivated cells would lead to regeneration of tissue with mechanical properties similar to reattached infraspinatus without tendon defects.</p> <p>Methods</p> <p>Layered PLLA fabric with a smooth surface on one side and a pile-finished surface on the other side was used. Novel form of layered PLLA scaffold was created by superimposing 2 PLLA fabrics. Defects of the infraspinatus tendon were created in 32 rabbits and the PLLA scaffolds were transplanted, four rabbits were used as normal control. Contralateral infraspinatus tendons were reattached to humeral head without scaffold implantation. Histological and mechanical evaluations were performed at 4, 8, and 16 weeks after operation.</p> <p>Results</p> <p>At 4 weeks postoperatively, cell migration was observed in the interstice of the PLLA fibers. Regenerated tissue was directly connected to the bone composed mainly of type III collagen, at 16 weeks postoperatively. The ultimate failure load increased in a time-dependent manner and no statistical difference was seen between normal infraspinatus tendon and scaffold group at 8 and 16 weeks postoperatively. There were no differences between scaffold group and reattach group at each time of point. The stiffness did not improve significantly in both groups.</p> <p>Conclusions</p> <p>A novel form of layered PLLA scaffold has the potential to induce cell migration into the scaffold and to bridge the tendon defect with mechanical properties similar to reattached infraspinatus tendon model.</p