Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model.

The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line. SEM cells were injected into the tail vein and engraftment was monitored by flow cytometry. Once engraftment was observed, mice were injected intraperitoneally with resveratrol (10 mg/kg body weight) dissolved in dimethylsulfoxide (DMSO) or DMSO alone (control) every other day, or vincristine (0.5 mg/kg body weight) 3 times per week for 4 weeks (n=16 per group). Comparisons of the percent of human leukemia cells in blood and survival curves showed resveratrol did not inhibit progression of the disease. Liquid chromatography-tandem mass spectrometry analyses of mouse sera showed resveratrol was rapidly metabolized to glucuronidated and sulfated forms 1 h post-injection, with low to no resveratrol or metabolites observed in sera by 24-48 h. These data indicate that in contrast to findings in in vitro models, parenterally administered resveratrol does not have potential as a preventive agent against high risk t(4;11) ALL

An evaluation of a short course in mindfulness for Health Visitor Practice Teachers

Practice Teachers (PTs) participated in an 8 week course, Mindfulness Based Cognitive for well-being and resilience. The evaluation was undertaken using three (3) evidenced based questionnaires: Perceived stress(PSS) (Cohen et al 1983), Self-Compassion Score SCS (Neff 2003) and Five Facet Mindfulness Questionnaire (FFMQ) (Baer et al 2006) to identify outcomes for the mindfulness training. Findings indicate the impact on personal wellbeing and professional practice with recommendations for retention of students & Health Visitor (HV) workforce. Summary Mindfulness skills to support top performance and good mental health were offered in eight two-hour sessions to 18 Practice Teachers from September- December 2014 and was evaluated. The course drew on the approach of Mindfulness Based Cognitive Therapy, where participants learn to focus their attention and develop the possibility of creating the space for reflection and response rather than reacting to life’s difficulties. Participants had the opportunity to develop self–care and self-compassion in the sessions as well as in between sessions and which research has shown can have a positive effect on others. Compassion is a contemporary theme in the CNO’s strategy to return to the fundamentals of nursing; mindfulness enables the foundation of practising compassion on self and ultimately to practice compassion with others we work and care for. The attendees were encouraged to review and refresh their practice through with the ultimate planned outcome, to reduce student attrition and prevent breakdown of the practice placement. However, this is a the complex area of adult learning and the nature of student attrition from courses as well as from the workforce cannot necessarily be reduced to one factor. The practice of mindfulness can have an influential effect on health, well-being and resilience, as shown by scientific and medical evidence. This experiential course was neither therapy nor religious instruction but an effective means of helping to alleviate stress and promoting well-being, resilience and flourishing. The course was delivered at a time when practitioners, including PTs were experiencing an increase of student numbers and service delivery changes with associated imperative data collection. The perception of practitioners about the declared increase in the HV workforce (DH 2011) to support and implement these changes was not evident and the evaluation indicates the need for self-care and resilience in the workforce which includes students and practitioners. The project outcomes make recommendations based on the impact of this mindfulness training with PTs to inform future developments within the programme and practice education as well as the HV workforce where a number of interventions call for 'mindfulness' with infants, children and families

Recent Decisions

Comments on recent decisions by Edward J. Flattery, John E. Cosgrove, Thomas Broden, Richard H. Keen, and Ralph L. Fenderson, Jr

DOC 2018-01 Human Sexuality Studies Certificate

Legislative Authority; Art. III. B. 1-7; DOC 2015-0

Rothamsted Conference RC No 5 : The art and science cultivation

RESP-51

Panoramic Views of the Cygnus Loop

We present a complete atlas of the Cygnus Loop supernova remnant in the light of [O III] (5007), H alpha, and [S II] (6717, 6731). Despite its shell-like appearance, the Cygnus Loop is not a current example of a Sedov-Taylor blast wave. Rather, the optical emission traces interactions of the supernova blast wave with clumps of gas. The surrounding interstellar medium forms the walls of a cavity through which the blast wave now propagates, including a nearly complete shell in which non-radiative filaments are detected. The Cygnus Loop blast wave is not breaking out of a dense cloud, but is instead running into confining walls. The interstellar medium dominates not only the appearance of the Cygnus Loop but also the continued evolution of the blast wave. If this is a typical example of a supernova remnant, then global models of the interstellar medium must account for such significant blast wave deceleration.Comment: 28 pages AAS Latex, 28 black+white figures, 6 color figures. To be published in The Astrophysical Journal Supplement Serie