Benchmark Calculations for the Triton Binding Energy for Modern NN Forces and the pi-pi Exchange Three-Nucleon Force

We present high precision benchmark calculations for the triton binding energy using the most recent, phase equivalent realistic nucleon-nucleon (NN) potentials and the Tuscon-Melbourne pi-pi three-nucleon force (3NF). That 3NF is included with partial waves up to a total two-body angular momentum of j_max=6. It is shown that the inclusion of the 3NF slows down the convergence in the partial waves and j_max=5 is needed in order to achieve converged results within a few keV. We adjust the cut-off parameter Lambda in the form factors of the Tuscon-Melbourne 3NF separately for the different NN potentials to the triton binding energy. This provides a set of phenomenological three-nucleon Hamiltonians which can be tested in three-nucleon scattering and systems with A>3. A connection between the probability to find two nucleons at short distances in the triton and the effect of that 3NF on the triton binding energy is pointed out.Comment: 18 pages REVTeX, 3 figure

Modern NN Force Predictions for the Total ND Cross Section up to 300 MeV

For several modern nucleon-nucleon potentials state-of-the-art Faddeev calculations are carried out for the $nd$ total cross section between 10 and 300 MeV projectile energy and compared to new high precision measurements. The agreement between theory and data is rather good, with exception at the higher energies where a 10% discrepancy builds up. In addition the convergence of the multiple scattering series incorporated in the Faddeev scheme is studied numerically with the result, that rescattering corrections remain important. Based on this multiple scattering series the high energy limit of the total $nd$ cross section is also investigated analytically. In contrast to the naive expectation that the total $nd$ cross section is the sum of the $np$ and $nn$ total cross sections we find additional effects resulting from the rescattering processes, which have different signs and different behavior as function of the energy. A shadowing effect in the high energy limit only occurs for energies higher than 300 MeV. The expressions in the high energy limit have qualitatively a similar behavior as the exactly calculated expressions, but can be expected to be valid quantitatively only at much higher energies.Comment: 22 pages, 5 figure

Towards an Intraoral-Based Silent Speech Restoration System for Post-laryngectomy Voice Replacement

© Springer International Publishing AG 2017, Silent Speech Interfaces (SSIs) are alternative assistive speech technologies that are capable of restoring speech communication for those individuals who have lost their voice due to laryngectomy or diseases affecting the vocal cords. However, many of these SSIs are still deemed as impractical due to a high degree of intrusiveness and discomfort, hence limiting their transition to outside of the laboratory environment. We aim to address the hardware challenges faced in developing a practical SSI for post-laryngectomy speech rehabilitation. A new Permanent Magnet Articulography (PMA) system is presented which fits within the palatal cavity of the user’s mouth, giving unobtrusive appearance and high portability. The prototype is comprised of a miniaturized circuit constructed using commercial off-the-shelf (COTS) components and is implemented in the form of a dental retainer, which is mounted under roof of the user’s mouth and firmly clasps onto the upper teeth. Preliminary evaluation via speech recognition experiments demonstrates that the intraoral prototype achieves reasonable word recognition accuracy and is comparable to the external PMA version. Moreover, the intraoral design is expected to improve on its stability and robustness, with a much improved appearance since it can be completely hidden inside the user’s mouth

Charge-Dependence of the Nucleon-Nucleon Interaction

Based upon the Bonn meson-exchange-model for the nucleon-nucleon ($NN$) interaction, we calculate the charge-independence breaking (CIB) of the $NN$ interaction due to pion-mass splitting. Besides the one-pion-exchange (OPE), we take into account the $2\pi$-exchange model and contributions from three and four irreducible pion exchanges. We calculate the CIB differences in the $^1S_0$ effective range parameters as well as phase shift differences for partial waves up to total angular momentum J=4 and laboratory energies below 300 MeV. We find that the CIB effect from OPE dominates in all partial waves. However, the CIB effects from the $2\pi$ model are noticable up to D-waves and amount to about 40% of the OPE CIB-contribution in some partial waves, at 300 MeV. The effects from 3$\pi$ and 4$\pi$ contributions are negligible except in $^1S_0$ and $^3P_2$.Comment: 12 pages, RevTex, 14 figure

Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

Rheumatoid arthritis (RA) is a common autoimmune disease that afflicts the synovium of diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully characterized, but may involve the loss of tolerance to posttranslationally modified (citrullinated) antigens. We have demonstrated that this modification leads to a selective increase in antigenic peptide affinity for major histocompatibility complex (MHC) class II molecules that carry the RA-associated shared epitope, such as HLA-DRB1*0401 (DR4). We describe the induction of arthritis in DR4-IE transgenic (tg) mice with citrullinated fibrinogen, a protein commonly found in inflamed synovial tissue and a frequent target of autoantibodies in RA patients. The disease induced in these mice was characterized by synovial hyperplasia followed by ankylosis, but lacked a conspicuous polymorphonuclear cell infiltrate. Immunological analysis of these mice through T cell epitope scanning and antibody microarray analysis identified a unique profile of citrulline-specific reactivity that was not found in DR4-IE tg mice immunized with unmodified fibrinogen or in wild-type C57BL/6 mice immunized with citrullinated fibrinogen, two conditions where arthritis was not observed. These observations directly implicate citrullinated fibrinogen as arthritogenic in the context of RA-associated MHC class II molecules

Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression

Introduction\ud Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to systematically analyse the phenotype, cytokine profile and frequency of interleukin-17 (IL-17) producing CD4-positive T cells in mononuclear cells isolated from peripheral blood, synovial fluid and synovial tissue of RA patients with established disease, and to correlate cell frequencies with disease activity. \ud \ud Methods\ud Flow cytometry was used to analyse the phenotype and cytokine production of mononuclear cells isolated from peripheral blood (PBMC) (n = 44), synovial fluid (SFMC) (n = 14) and synovium (SVMC) (n = 10) of RA patients and PBMC of healthy controls (n = 13). \ud \ud Results\ud The frequency of IL-17-producing CD4 T cells was elevated in RA SFMC compared with RA PBMC (P = 0.04). However, the frequency of this population in RA SVMC was comparable to that in paired RA PBMC. The percentage of IL-17-producing CD4 T cells coexpressing tumor necrosis factor alpha (TNFα) was significantly increased in SFMC (P = 0.0068). The frequency of IFNγ-producing CD4 T cells was also significantly higher in SFMC than paired PBMC (P = 0.042). The majority of IL-17-producing CD4 T cells coexpressed IFNγ. IL-17-producing CD4 T cells in RA PBMC and SFMC exhibited very little IL-22 or IL-23R coexpression. \ud \ud Conclusions\ud These findings demonstrate a modest enrichment of IL-17-producing CD4 T cells in RA SFMC compared to PBMC. Th17 cells in SFMC produce more TNFα than their PBMC counterparts, but are not a significant source of IL-22 and do not express IL-23R. However, the percentage of CD4 T cells which produce IL-17 in the rheumatoid joint is low, suggesting that other cells may be alternative sources of IL-17 within the joints of RA patients. \ud \u