A Language and Toolset for the Synthesis and Efficient Simulation of Clock-Cycle-True Signal-Processing Algorithms

Optimal simulation speed and synthesizability are contradictory requirements for a hardware description language. This paper presents a language and toolset that enables both synthesis and fast simulation of fixed-point signal processing algorithms at the register-transfer level using a single system description. This is achieved by separate code generators for different purposes. Code-generators have been developed for fast simulation (using ANSI-C) and for synthesis (using VHDL). The simulation performance of the proposed approach has been compared with other known methods and turns out to be comparable in speed to the fastest among them

Implementation of a Combined OFDM-Demodulation and WCDMA-Equalization Module

For a dual-mode baseband receiver for the OFDMWireless LAN andWCDMA standards, integration of the demodulation and equalization tasks on a dedicated hardware module has been investigated. For OFDM demodulation, an FFT algorithm based on cascaded twiddle factor decomposition has been selected. This type of algorithm combines high spatial and temporal regularity in the FFT data-flow graphs with a minimal number of computations. A frequency-domain algorithm based on a circulant channel approximation has been selected for WCDMA equalization. It has good performance, low hardware complexity and a low number of computations. Its main advantage is the reuse of the FFT kernel, which contributes to the integration of both tasks. The demodulation and equalization module has been described at the register transfer level with the in-house developed Arx language. The core of the module is a pipelined radix-23 butterfly combined with a complex multiplier and complex divider. The module has an area of 0.447 mm2 in 0.18 ¿m technology and a power consumption of 10.6 mW. The proposed module compares favorably with solutions reported in literature

Spectral Analysis of Correlated One-Dimensional Systems with Impurities

An averaging procedure is proposed to account for spectral features of correlated one-dimensional systems in the presence of non-magnetic impurities. The dynamical spin structure factor for a corresponding random ensemble of Heisenberg chain segments is calculated by exact numerical diagonalization. It is shown that a few-pole approximation is sufficient to describe the numerical results. A similar analysis is proposed for the discussion of experimental spectra, such as obtained by inelastic neutron scattering measurements on Zn-doped CuO chains. By examination of the disorder-induced pseudo-gap, the loss of spectral weight, and the discrete peak structures due to smallest-cluster contributions, the underlying impurity distribution function can be determined.Comment: RevTex, 4 pages with 4 eps figure

Implementaion of a combined OFDM-demodulation and WCDMA-equalization module

For a dual-mode baseband receiver for the OFDMWireless LAN andWCDMA standards, integration of the demodulation and equalization tasks on a dedicated hardware module has been investigated. For OFDM demodulation, an FFT algorithm based on cascaded twiddle factor decomposition has been selected. This type of algorithm combines high spatial and tempo- ral regularity in the FFT data-flow graphs with a minimal number of computations. A frequency-domain algorithm based on a circulant channel approximation has been se- lected forWCDMA equalization. It has good performance, low hardware complexity and a low number of computa- tions. Its main advantage is the reuse of the FFT kernel, which contributes to the integration of both tasks. The demodulation and equalization module has been de- scribed at the register transfer level with the in-house developed Arx language. The core of the module is a pipelined radix-23 butterfly combined with a complex mul- tiplier and complex divider. The module has an area of 0.447 mm2 in 0.18 μm technology and a power consump- tion of 10.6 mW. The proposed module compares favorably with solutions reported in literature. Keywords—OFDMdemodulation,WCDMA, frequency- domain equalization, architecture design

Estimated Worldwide Mortality Attributed to Secondhand Tobacco Smoke Exposure, 1990-2016

Importance: The World Health Organization estimates that the 1 billion individuals who smoke worldwide contribute to the 880 000 secondhand smoke (SHS)-related deaths among individuals who do not smoke each year. A better understanding of the scale of harm of SHS to those who do not smoke could increase awareness of the consequences of smoking and help to design measures to protect individuals who do not smoke, especially children. Objective: To calculate the number of individuals who smoke associated with the death of 1 individual who died of SHS exposure both on a global scale and in various World Bank regions. Design, Setting, and Participants: In this cross-sectional epidemiologic assessment, data from Our World in Data were used to tabulate the number of individuals who smoke in each country and number of premature deaths related to SHS in that country from 1990 to 2016. The mean number of cigarettes consumed in all countries was also included in analyses. Data were collected for the following World Bank regions: North America, Latin America and the Caribbean, Europe and Central Asia, the Middle East and North Africa, sub-Saharan Africa, South Asia, and East Asia and the Pacific from 1990 and 2016. Statistical analysis was conducted in July 2019. Exposure: Secondhand smoke. Main Outcomes and Measures: The pack-year index, calculated as the number of pack-years associated with the death of 1 individual who does not smoke but was exposed to SHS, and the SHS index, calculated as the number of individuals who smoked for 24 years (ie, the mean duration of smoking) associated with the death of 1 individual who does not smoke. Results: Globally, the SHS index changed favorably, from 31.3 (95% CI, 30.6-32.0) individuals who smoked associated with the death of 1 individual who did not smoke in 1990 to 52.3 (95% CI, 51.2-53.5) individuals who smoked in 2016. There was a wide regional variation in the 2016 secondhand smoke index, from 42.6 (95% CI, 41.6-43.5) individuals who smoked in the Middle East and North Africa to 85.7 (95% CI, 83.8-87.7) individuals who smoked in North America. Worldwide, the pack-year index also changed favorably from 751.9 (95% CI, 736.3-770.7) pack-years associated with 1 death in 1990 to 1255.9 (95% CI, 1227.2-1284.4) pack-years in 2016. Conclu

Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks

While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts can be used to help generate diverse building blocks for drug discovery. Here we show the engineering of two variants of Rhodothermus marinus nitric oxide dioxygenase (RmaNOD) to catalyze the formation of cis- and trans-diastereomers of a pinacolboronate-substituted cyclopropane which can be readily derivatized to generate diverse stereopure cyclopropane building blocks

Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks

While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts can be used to help generate diverse building blocks for drug discovery. Here we show the engineering of two variants of Rhodothermus marinus nitric oxide dioxygenase (RmaNOD) to catalyze the formation of cis- and trans-diastereomers of a pinacolboronate-substituted cyclopropane which can be readily derivatized to generate diverse stereopure cyclopropane building blocks

Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury

Ventilator-induced lung injury (VILI) is associated with inhibition of the fibrinolytic system secondary to increased production of plasminogen activator inhibitor- (PAI-)1. To determine the role of PAI-1 on pulmonary coagulopathy and inflammation during mechanical ventilation, PAI-1 gene-deficient mice and their wild-type littermates were anesthetized (control), or anesthetized, tracheotomized and subsequently ventilated for 5 hours with either low tidal volumes (LVT) or high tidal volumes (HVT). VILI was assessed by pulmonary coagulopathy, lung wet-to-dry ratios, total protein level in bronchoalveolar lavage fluid, neutrophil influx, histopathology, and pulmonary and plasma cytokine levels. Ventilation resulted in pulmonary coagulopathy and inflammation, with more injury following ventilation with HVT as compared to LVT. In PAI-1 gene-deficient mice, the influx of neutrophils in the pulmonary compartment was attenuated, while increased levels of pulmonary cytokines were found. Other endpoints of VILI were not different between PAI-1 gene-deficient and wild-type mice. These data indicate that a defect fibrinolytic response attenuates recruitment of neutrophils in VILI