131 research outputs found
Big data and tactical analysis in elite soccer: future challenges and opportunities for sports science
Change of the differentiation pattern of amphibian ectoderm after the increase of the initial cell mass
Classical embryology to molecular biology: a personal view of amphibian embryonic development
The differentiation of isolated amphibian ectoderm with or without treatment with an inductor
Differentiation of the four animal and the four vegetal blastomeres of the eight-cell-stage ofTriturus alpestris
Regionalized metabolic activity establishes boundaries of retinoic acid signalling.
The competence of a cell to respond to the signalling molecule retinoic acid (RA) is thought to depend largely on its repertoire of cognate zinc finger nuclear receptors. XCYP26 is an RA hydroxylase that is expressed differentially during early Xenopus development. In Xenopus embryos, XCYP26 can rescue developmental defects induced by application of exogenous RA, suggesting that the enzymatic modifications introduced inhibit RA signalling activities in vivo. Alterations in the expression pattern of a number of different molecular markers for neural development induced upon ectopic expression of XCYP26 reflect a primary function of RA signalling in hindbrain development. Progressive inactivation of RA signalling results in a stepwise anteriorization of the molecular identity of individual rhombomeres. The expression pattern of XCYP26 during gastrulation appears to define areas within the prospective neural plate that develop in response to different concentrations of RA. Taken together, these observations appear to reflect an important regulatory function of XCYP26 for RA signalling; XCYP26-mediated modification of RA modulates its signalling activity and helps to establish boundaries of differentially responsive and non-responsive territories
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