The effect of hydroalcoholic extract of olea europea L. Leaf on Blood pressure and its interaction with adrenergic system of male rats

Introduction: Hypertension is one of the most common and important disease factors imposed by the modern lifestyle, in particular by reduced physical activity and an unbalanced lipid-rich diet. One of the best methods for treatment of hypertension is the use of medical herbs that have moderate effects on blood pressure such as Olive (Olea europea L.). Therefore, the purpose of this study was to evaluate the effect of hydroalcoholic extract of olea europea L. Leaf on blood pressure and its interaction with adrenergic system of male rats Methods: In this experimental study, 10 adult male wistar rats weighing between180-250g were used. They were divided into two groups (each group contained 5 rats) randomly: olive leaf extract group and olive leaf extract and adrenaline group. Then, each rat was anesthetized by IP injection of 1.2 g/kg urethane. After tracheostomy, the femoral vine and artery were cannulated for drug injection and blood pressure recording respectively. Arterial cannula for recording arterial blood pressure connected to a pressure transducer linked to Power lab. Blood pressure parameters (systolic, diastolic and mean arterial pressure) were recorded before and after IV administration of hydroalcoholic extract of olea europea L. leaf, solvent, adrenaline and olive leaf extract with adrenaline.The data were analyzed using SPSS software. Results: The results showed a significant decrease of systolic, diastolic and mean arterial pressures in comparison with the control and sham groups (P<0.05). Also, a significant decrease of blood pressure showed in presence of olive leaf extract and adrenaline with compare to the sham group (P<0.05). Conclusion: It can be concluded that olea europea L. leaf may suggested as a hypotensive agent. It seems that this effect is due to the inhibition of the adrenergic syste