Including the siblings of youth substance abusers in a parent-focused intervention : a pilot test of the best plus program

Substance use is common among young people and can escalate into significant problems for affected individuals and their families. Family responses can influence the course of youth substance use and its consequences for family members, including parents and siblings. Family-level interventions developed to date have neglected the important role that siblings can play. This article describes a pilot test of an intervention designed to assist parents and siblings affected by youth substance use and related problems. The BEST Plus intervention consisting of professionally-led, multifamily groups sequenced over eight sessions is described with reference to the intended therapeutic processes. Professionally observed and self-reported changes for family participants including siblings suggested that the program had a beneficial therapeutic impact. This evaluation of early impacts suggests the BEST Plus programoffers a promising means of assisting families to respond to substance use problems in young people.<br /

Multiskilled Health Practitioners: Results of a Graduate Assessment

To ascertain the assimilation of graduates into multiskilled practice, the Add-A-Comp Program, Methodist Hospital of Indiana, conducted an assessment of graduates over a 30-month period. Input was received both from the program’s graduates and supervisors of the graduates. Of the 40 responding graduates, 24 (60%) had functioned in a multiskilled capacity. The majority of graduates reported increased job satisfaction, security, challenge, opportunities, and perceived value to their employer resulting from their multiskilled employment, with 58% receiving additional compensation for multiskilled functioning. Of the 24 supervisor respondents, 92% felt that their multiskilled graduates’ knowledge and competency levels had met their expectations and that the sponsorship was worth the investment. Many of the Add-A-Comp modules utilize a self-directed learning packet approach with 92% of graduates using these packets indicating an excellent or satisfactory rating for this instructional method

Life story and narrative approaches in the study of family lives

The chapter examines life story and narrative approaches and their application in the study of family lives. It begins with a brief history of some key figures in biographical research followed by an examination of some of the distinctions between the two approaches. The second part of the chapter presents and discusses a case of a grandfather and son drawn from an intergenerational study of fatherhood. The study’s method (the biographic-narrative interpretive method) demonstrates change and continuity in family life by situating lives in historical context and examining the cultural transmissions that are accepted and resisted by the younger generation. The chapter discusses the benefits of paying attention to the narrative form of life stories. In these ways biographical and narrative approaches produce a multi-layered analysis

Effects of ionizing radiation in combination with Erufosine on T98G glioblastoma xenograft tumours: a study in NMRI nu/nu mice

BACKGROUND: Erufosine is a promising anticancer drug that increases the efficacy of radiotherapy in glioblastoma cell lines in vitro. Moreover, treatment of nude mice with repeated intraperitoneal or subcutaneous injections of Erufosine is well tolerated and yields drug concentrations in the brain tissue that are higher than the concentrations required for cytotoxic drug effects on glioblastoma cell lines in vitro. METHODS: In the present study we aimed to evaluate the effects of a combined treatment with radiotherapy and Erufosine on growth and local control of T98G subcutaneous glioblastoma xenograft-tumours in NMRI nu/nu mice. RESULTS: We show that repeated intraperitoneal injections of Erufosine resulted in a significant drug accumulation in T98G xenograft tumours on NMRI nu/nu mice. Moreover, short-term treatment with 5 intraperitoneal Erufosine injections caused a transient decrease in the growth of T98G tumours without radiotherapy. Furthermore, an increased radiation-induced growth delay of T98G xenograft tumours was observed when fractionated irradiation was combined with short-term Erufosine-treatment. However, no beneficial drug effects on fractionated radiotherapy in terms of local tumour control were observed. CONCLUSIONS: We conclude that short-term treatment with Erufosine is not sufficient to significantly improve local control in combination with radiotherapy in T98G glioblastoma xenograft tumours. Further studies are needed to evaluate efficacy of extended drug treatment schedules

Characterizing Triviality of the Exponent Lattice of A Polynomial through Galois and Galois-Like Groups

The problem of computing \emph{the exponent lattice} which consists of all the multiplicative relations between the roots of a univariate polynomial has drawn much attention in the field of computer algebra. As is known, almost all irreducible polynomials with integer coefficients have only trivial exponent lattices. However, the algorithms in the literature have difficulty in proving such triviality for a generic polynomial. In this paper, the relations between the Galois group (respectively, \emph{the Galois-like groups}) and the triviality of the exponent lattice of a polynomial are investigated. The \bbbq\emph{-trivial} pairs, which are at the heart of the relations between the Galois group and the triviality of the exponent lattice of a polynomial, are characterized. An effective algorithm is developed to recognize these pairs. Based on this, a new algorithm is designed to prove the triviality of the exponent lattice of a generic irreducible polynomial, which considerably improves a state-of-the-art algorithm of the same type when the polynomial degree becomes larger. In addition, the concept of the Galois-like groups of a polynomial is introduced. Some properties of the Galois-like groups are proved and, more importantly, a sufficient and necessary condition is given for a polynomial (which is not necessarily irreducible) to have trivial exponent lattice.Comment: 19 pages,2 figure