11. Looking Back

From Alumni Views, Robert H. Bluestein (’67), “ILR addressed the social and economic issues of the times and sought to provide students with the tools to find solutions to many of the problems confronting society in the mid-to late-sixties. This was a period easily described as volatile, evolutionary, and sometimes revolutionary. As would have been the case at any vibrant institution, the curriculum and the students at ILR reflected those times.” Includes: Alumni Views of ILR; The Creation of the Alpern Scholarship and Prize; and A Professor’s Perspective

Prevention of Doxorubicin-induced cardiotoxicity by a coumestan analogue, Psoralidin

Natural phenolic compound Psoralidin limits cardiotoxicity associated with Doxorubici

11. Looking Back

From Alumni Views, Robert H. Bluestein (’67), “ILR addressed the social and economic issues of the times and sought to provide students with the tools to find solutions to many of the problems confronting society in the mid-to late-sixties. This was a period easily described as volatile, evolutionary, and sometimes revolutionary. As would have been the case at any vibrant institution, the curriculum and the students at ILR reflected those times.” Includes: Alumni Views of ILR; The Creation of the Alpern Scholarship and Prize; and A Professor’s Perspective.Part11LookingBackILRat50.pdf: 546 downloads, before Oct. 1, 2020

Fulminant hepatic failure associated with status epilepticus in children: three cases and a review of potential mechanisms

Fulminant hepatic failure is a rare complication of status epilepticus. Although many of the anticonvulsants used to treat the seizures are known to have hepatotoxic properties, the exact mechanism leading to massive destruction of the liver following a prolonged seizure remains unclear. Three children are presented who developed fulminant hepatic failure following status epilepticus and subsequently died of multiple organ failure. The literature is reviewed with particular attention to the possible interaction between the anticonvulsants and the metabolic consequences of status epilepticus. We postulate that it is a combination of hypoxia and ischemia that occurs during a prolonged seizure with altered metabolism of free radicals secondary to the anticonvulsant drugs which leads to widespread hepatocyte membrane damag

Increased energy expenditure in growing adolescents with Crohn's disease

Undernutrition is considered to have a central role in the pathogenesis of growth retardation in Crohn's disease. This may occur as a consequence of inadequate food intake, increased energy expenditure, or both. Ten growing adolescents with inactive Crohn's disease were assessed with respect to anthropometric parameters and resting energy expenditure, measured by indirect calorimetry during remission, repeated in relapse (N = 5), and compared to that predicted from the Harris-Benedict formula. Mean energy intake was assessed with seven-day diaries in five patients and compared to recommended intake for age, sex, weight, and physical activity. Ten healthy, growing, age- and sex-matched adolescents served as controls. Nine patients with inactive Crohn's disease, who had ceased growing, were matched for disease site and duration and acted as disease controls. Patients and disease controls had lower body mass index (19.2 ± 0.6; 20.9 ± 0.7) than healthy controls (23.7 ± 0.6; P < 0.001). Percent body fat was lower in patients (13.2 ± 1.9%) compared to healthy controls (20.5 ± 2.4%; P < 0.05) but not to disease controls (17.0 ± 2.6%). Patients had higher resting energy expenditure per kilogram of fat-free mass than disease or healthy controls (36.9 ± 5.1; 32.9 ± 2.6; 30.9 ± 2.1 kcal; P < 0.02). Measured resting energy expenditure in patients, but not in disease or healthy controls, was higher than the predicted (measured: predicted 1.15, 1.03, 0.9, respectively; P < 0.03). Energy intake in patients was 97% of recommended intake but the measured ratio of energy intake/resting energy expenditure was lower than the predicted ratio (1.49 vs 1.71; P < 0.05). During subsequent relapse in five patients resting energy expenditure was unchanged. In growing adolescents with inactive Crohn's disease, there is increased energy expenditure that is not accompanied by an increase in energy intake; Relapse of disease does not appear to increase resting energy expenditure further but may 'divert' energy from growth to disease activity. This suggests that nutritional therapy should be directed towards increasing caloric intake to maximize growth potential