35 research outputs found
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠΏΡΠΎΡΠ½Π΅Π½ΠΈΡ Π½Π°Π³ΡΡΠΆΠ΅Π½Π½ΡΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΌΠ½ΠΎΠ³ΠΎΡ ΠΎΠ΄ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅ΠΊΠ»ΡΡΠ°ΡΠ΅Π»Ρ ΡΠΊΠ²Π°ΠΆΠΈΠ½ Ρ ΡΠ΅Π»ΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΠ΅ΡΡΡΡΠ° Π΅Π³ΠΎ ΡΠ°Π±ΠΎΡΡ
Π Π°Π±ΠΎΡΠ° Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π° Π½Π° ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠ·Π»Π° ΠΌΠ½ΠΎΠ³ΠΎΡ
ΠΎΠ΄ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅ΠΊΠ»ΡΡΠ°ΡΠ΅Π»Ρ ΡΠΊΠ²Π°ΠΆΠΈΠ½ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ°ΡΡΠ΅ΡΠ° Π½Π΅ΡΡΠΈ Π½Π° ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΈ ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΡΠ°ΡΡΠ΅ΡΡ Π½Π° Π΅Π΅ ΠΎΡΠ½ΠΎΠ²Π΅ Ρ ΡΠ΅Π»ΡΡ Π²ΡΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΠΏΠΎ ΡΠΏΡΠΎΡΠ½Π΅Π½ΠΈΡ ΡΠ°Π±ΠΎΡΠΈΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠ»Π°ΠΏΠ°Π½Π°, ΠΏΠΎΠ΄Π²Π΅ΡΠΆΠ΅Π½Π½ΡΡ
ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΌΡ ΠΈΠ·Π½ΠΎΡΡ. ΠΠ½Π°Π»ΠΈΠ·ΠΈΡΡΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΠΎ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ ΠΠ‘Π, ΠΌΠΎΠ΄Π΅ΡΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΠΊΠΎΡΠΏΡΡΠ° ΠΈ Π΄ΡΡΠ³ΠΈΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ², ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡΠ΅ΠΉΡΠΈ ΠΊ Π²ΡΠ²ΠΎΠ΄Ρ ΠΎΠ± Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ΅ΠΌΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠ»ΡΡΠΎΠΉ ΡΡΠ΄ ΠΏΠ°ΡΠ΅Π½ΡΠΎΠ² ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΌΠΎΠ΄Π΅ΡΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΠΊΠΎΡΠΏΡΡΠ° ΠΠ‘Π. Π ΡΠ΄ Π½Π°ΡΡΠ½ΡΡ
ΡΡΠ°ΡΠ΅ΠΉ ΠΎΠΏΠΈΡΡΠ²Π°Π΅Ρ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΈΠ·Π½ΠΎΡΠ°. ΠΠ‘Π ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΌΠ΅ΡΡΠ½ΠΎ Π½Π° Π½Π΅ΡΡΠ΅Π³Π°Π·ΠΎΠ²ΠΎΠΌ ΠΏΡΠΎΠΌΡΡΠ»Π΅, Π²ΡΡ
ΠΎΠ΄ ΠΈΠ· ΡΡΡΠΎΡ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ΅ΠΌΠΎΠ½ΡΡ ΠΈ ΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠ΅ Π»ΠΈΠ½ΠΈΠΈ, Π° ΠΊΠ°ΠΊ ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΠΊ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ Π·Π°ΡΡΠ°ΡΠ°ΠΌ Π½Π° ΠΏΡΠΎΡΡΠΎΠΉ, ΡΠ΅ΠΌΠΎΠ½Ρ, Π»ΠΈΠ±ΠΎ Π·Π°ΠΌΠ΅Π½Ρ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ· ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Ρ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° Π΄Π°Π½Π½ΡΡ
Π²ΠΈΠ΄Π½Ρ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΈΠ·Π½ΠΎΡΠ° ΡΠ°Π±ΠΎΡΠΈΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠΎΡΠΏΡΡΠ°.The work is aimed at building a model of the multi-pass switch node of the oil calculation system on the field and subsequent calculations based on it in order to develop recommendations for strengthening the working elements of the valve that are subject to intense wear. Analyzing the literature on the design of the PSM, the modernization of the housing and other elements, we can come to a conclusion about the relevance of the research topic. A large number of patents offer various upgrades to the PSM case. A number of scientific articles describe wear problems. PSM is used everywhere in the oil and gas field, failure leads to the repair and installation of the line, and as a result to the economic costs of downtime, repair, or replacement of equipment. From the data obtained from produc
ΠΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠ΅ ΡΡΠ΅Π΄ΡΡΠ²ΠΎ Π΄Π»Ρ Π°Π½Π°Π»ΠΈΠ·Π° Π΄Π°Π½Π½ΡΡ , ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Π² ΠΏΠ°ΠΊΠ΅ΡΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌ MCU ΠΏΡΠΈ ΡΠ°ΡΡΠ΅ΡΠ΅ ΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π°ΠΊΡΠΎΡΠ°
ΠΠ΅Π±-ΡΠ΅ΡΠ²ΠΈΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ ΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΎΡΠΈΠ±ΠΎΠΊ Π² Π΄Π°Π½Π½ΡΡ Π½Π° ΠΏΡΠΎΠΌΡΡΠ»Π°Ρ Π½Π΅ΡΡΠ΅Π³Π°Π·ΠΎΠ΄ΠΎΠ±ΡΠ²Π°ΡΡΠΈΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ
Aerosols formation and alteration simulation in the primary heat carrier circuit of a NPPβs reactor during a hypothetical beyond design conditions accident involving fission products release
ΠΠ°Π½ΠΊΠΎΠ²ΡΠΊΠ°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π Π€
Π Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½Ρ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΏΠΎ ΡΠ΅ΠΌΠ΅ "ΠΠ°Π½ΠΊΠΎΠ²ΡΠΊΠ°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π Π€", Π² ΠΊΠΎΡΠΎΡΠΎΠΉ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΠΎΠ½ΡΡΠΈΡ, ΡΡΠ½ΠΊΡΠΈΠΈ ΠΈ ΡΡΡΡΠΊΡΡΡΠ°, ΠΏΠΎΠΊΠ°Π·Π°Π½Ρ ΡΠ΅ΠΉΡΠΈΠ½Π³ Π±Π°Π½ΠΊΠΎΠ², ΡΡΡΠ½ΠΎΡΡΡ Π±Π°Π½ΠΊΠΎΠ²ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π Π€
Entwicklung und Charakterisierung von In-vitro-Test-Systemen zur Evaluierung dermatopharmakologischer und dermatotoxikologischer Fragestellungen
Entwicklung und Charakterisierung von In-vitro-Test-Systemen zur Evaluierung dermatopharmakologischer und dermatotoxikologischer Fragestellungen
Der EinfluΓ systemischer Wachstumshormongabe auf die Spalthautdefektheilung beim Schwein
Ultima-ratio therapies in adult burn patients using recombinant human growth hormone, revealed a faster healing of split thickness skin graft donor sites. Furthermore, no standardized studies about the influence of different wound dressings on the healing time of split thickness skin graft donor sites are available. Goal of this animal experiment was, to study the influence of systemic growth hormone administration and different wound dressings on the healing time of split thickness skin graft donor sites under standardized conditions in an adult pig model. In 15 (8 verum, 7 control) adult, male pigs a total of 30, 0.6 mm deep split thickness wounds, size 8 x 4 cm were created on the back of the pigs. Six split thickness wounds were assigned in one group and treated with different wound dressings, namingly a dry wound dressing (Braunovidon), a calcium-alginate dressing (Kaltostat), silk, a polyurethane dressing (OpSite) and a hydrocolloid dressing (Varihesive E). Pigs were followed up for 14 days and daily treated subcutaneously with recombinant human growth hormone (0,5 I.E./kg KG) or 4 ml 0.9% sodium chloride. Every 2-3 days dressing exchange was performed. One punch biopsy per group was taken out of the wound ground and the healing progress was photo documented. Furthermore, a blood sample was taken from the pigs to determine the expression of IGF-1, the peripheral mediator of growth hormone. Biopsies were histologically stained with H & E and basal membrane components were examined using immunhistochemical techniques and antibodies directed against laminin 5, collagen IV and VII. The criterion for a healed wound was a starting stratification of the newly formed epidermis. Serum IGF-1 was statistically significant increased in the verum group, when compared to the control group. Clinically and histologically the split skin graft donor sites treated with Varihesive E, OpSite and Braunovidon showed a significant faster healing rate of 1.36-2.87 days in the verum groups compared to the control group. Wounds treated with Kaltostat or silk healed faster, the difference however, was not statistically significant. Immunhistochemical analysis revealed a rebuild basal membrane zone at day 7-8 in all groups. In this standardized adult animal experiments we could demonstrate a statistically significant increase in serum IGF-1, as well as an improved healing of split thickness wounds in animals treated with recombinant human growth hormone. The increase of IGF-1 in the serum after treatment with growth hormone correlates positively with an improvement in wound healing in this group. Assuming that these results are transferable into humans, the application of systemic growth hormone in severely burned patients might indeed be useful to improve the healing time and of split skin graft donor sites