Diaqua­bis(2-chloro­benzoato-κO)bis­(N,N-diethyl­nicotinamide-κN 1)manganese(II)

In the monomeric title complex, [Mn(C7H4ClO2)2(C10H14N2O)2(H2O)2], the MnII atom is located on a crystallographic centre of inversion. The asymmetric unit contains one 2-chloro­benzoate (CB) ligand, one diethyl­nicotinamide (DENA) ligand and one coordinated water mol­ecule, all ligands being monodentate. The four O atoms in the equatorial plane around the Mn atom form a slightly distorted square-planar arrangement, while the slightly distorted octa­hedral coordination is completed by the two pyridine N atoms of the DENA ligands in the axial positions. The dihedral angle between the carboxyl group and the adjacent benzene ring is 77.9 (11)°, while the pyridine and benzene rings are oriented at a dihedral angle of 45.94 (5)°. In the crystal structure, inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into infinite chains

Crystal structure of trans-(1RS,3RS)-2-N,N'-dimethylaminomethyl-1,3-dithiolane-1,3-dioxide

The title compound, C6H13NO2S2, consists of a five-membered dithiolane ring with one O atom bonded to each S atom and a dimethylaminomethyl group at the 2-position. The asymmetric unit contains three molecules. All of the S1, S2 and C1 atoms are likely to be stereogenic. 2006 © The Japan Society for Analytical Chemistry

N-(p-nitrophenylsulfonyl)-1H-pyrrole

In the title compound, C10H8N2O 4S, the dihedral angle between the pyrrole and benzene rings is 77.9 (1)°. Inter-molecular C - H?O hydrogen bonds stabilize the crystal structure, forming molecular chains extending approximately parallel to the c axis and stacked along the b axis. © 2004 International Union of Crystallography Primed in Great Britain - all rights reserved

N,N-Bis[2-(2-fur-yl)-2-(hydroxy-imino)-eth-yl]aniline

In the crystal structure of the title compound, C18H17N3O4, intra-molecular C - H?O hydrogen bonds cause the formation of two planar five-membered rings, which are also coplanar with the adjacent rings. The oxime units have E configurations and their bond lengths and angles compare well with those in related compounds. In this configuration, the oxime groups are involved as donors in O - H?N hydrogen bonds, linking the mol-ecules into chains extending approximately parallel to the c axis and stacked along the b axis. © International Union of Crystallography 2007

Crystal structure of (3R,4R,5R)-3,4,6-tri-O-benzyl-D-glucal

The title compound, C27H28O4, consisting of three O-benzyl modieties and one glucal modiety, belongs to the space group P21 with cell parameters a = 12.0729(5), b = 4.7002(2), c = 19.6720(8)Å and ß = 90.989(4)°. The glucal moiety has a twist-boat conformation. 2005 © The Japan Society for Analytical Chemistry

2-methoxymethyl-1,3-dithiepane 1,1,3,3-tetraoxide

The title compound, C7H14O5S2, consists of a seven-membered dithiepane ring with two O atoms bonded to each S atom and a methoxymethyl group at the 2-position. A few close contacts seem to influence the geometry of the dithiepane ring. © 2003 International Union of Crystallography Printed in Great Britain - all rights reserved

Supramolecular Gag-Like Self-Assembled Glycopeptide Nanofibers Induce Chondrogenesis and Cartilage Regeneration

Glycosaminoglycans (GAGs) and glycoproteins are vital components of the extracellular matrix, directing cell proliferation, differentiation, and migration and tissue homeostasis. Here, we demonstrate supramolecular GAG-like glycopeptide nanofibers mimicking bioactive functions of natural hyaluronic acid molecules. Self-assembly of the glycopeptide amphiphile molecules enable organization of glucose residues in close proximity on a nanoscale structure forming a supramolecular GAG-like system. Our in vitro culture results indicated that the glycopeptide nanofibers are recognized through CD44 receptors, and promote chondrogenic differentiation of mesenchymal stem cells. We analyzed the bioactivity of GAG-like glycopeptide nanofibers in chondrogenic differentiation and injury models because hyaluronic acid is a major component of articular cartilage. Capacity of glycopeptide nanofibers on in vivo cartilage regeneration was demonstrated in microfracture treated osteochondral defect healing. The glycopeptide nanofibers act as a cell-instructive synthetic counterpart of hyaluronic acid, and they can be used in stem cell-based cartilage regeneration therapies