A Statistical Verification Method of Random Permutations for Hiding Countermeasure Against Side-Channel Attacks

As NIST is putting the final touches on the standardization of PQC (Post Quantum Cryptography) public key algorithms, it is a racing certainty that peskier cryptographic attacks undeterred by those new PQC algorithms will surface. Such a trend in turn will prompt more follow-up studies of attacks and countermeasures. As things stand, from the attackers' perspective, one viable form of attack that can be implemented thereupon is the so-called "side-channel attack". Two best-known countermeasures heralded to be durable against side-channel attacks are: "masking" and "hiding". In that dichotomous picture, of particular note are successful single-trace attacks on some of the NIST's PQC then-candidates, which worked to the detriment of the former: "masking". In this paper, we cast an eye over the latter: "hiding". Hiding proves to be durable against both side-channel attacks and another equally robust type of attacks called "fault injection attacks", and hence is deemed an auspicious countermeasure to be implemented. Mathematically, the hiding method is fundamentally based on random permutations. There has been a cornucopia of studies on generating random permutations. However, those are not tied to implementation of the hiding method. In this paper, we propose a reliable and efficient verification of permutation implementation, through employing Fisher-Yates' shuffling method. We introduce the concept of an n-th order permutation and explain how it can be used to verify that our implementation is more efficient than its previous-gen counterparts for hiding countermeasures.Comment: 29 pages, 6 figure

A Statistical Verification Method of Random Permutations for Hiding Countermeasure Against Side-Channel Attacks

As NIST is putting the final touches on the standardization of PQC (Post Quantum Cryptography) public key algorithms, it is a racing certainty that peskier cryptographic attacks undeterred by those new PQC algorithms will surface. Such a trend in turn will prompt more follow-up studies of attacks and countermeasures. As things stand, from the attackers’ perspective, one viable form of attack that can be implemented thereupon is the so-called “side-channel attack”. Two best-known countermeasures heralded to be durable against side-channel attacks are: “masking” and “hiding”. In that dichotomous picture, of particular note are successful single-trace attacks on some of the NIST’s PQC then-candidates, which worked to the detriment of the former: “masking”. In this paper, we cast an eye over the latter: “hiding”. Hiding proves to be durable against both side-channel attacks and another equally robust type of attacks called “fault injection attacks”, and hence is deemed an auspicious countermeasure to be implemented. Mathematically, the hiding method is fundamentally based on random permutations. There has been a cornucopia of studies on generating random permutations. However, those are not tied to implementation of the hiding method. In this paper, we propose a reliable and efficient verification of permutation implementation, through employing Fisher–Yates’ shuffling method. We introduce the concept of an -th order permutation and explain how it can be used to verify that our implementation is more efficient than its previous-gen counterparts for hiding countermeasures

Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo−/− mice

AbstractUnlike most other mammals, human bodies do not have the ability to synthesize vitamin C inside of their own bodies. Therefore, humans must obtain vitamin C through daily diet. Gulo−/− mice strain is known with deficiency, in which vitamin C intake can be controlled by diet like human, and would be valuable for investigating the molecular mechanism of various diseases. In the present study, we established Gulo−/− mice model and investigated the differentially expressed proteins in stomach tissue of Gulo−/− mice after Helicobacter pylori-infected, and followed by DENA, using immunohistochemistry and proteomic approach. The results of immunohistochemistry analysis of stomach tissue showed that the tumor suppressor, p53 protein, expression was significantly decreased (p<0.05) but not messenger RNA (mRNA) transcriptional level, and 14-3-3ε, 14-3-3δ, Ki-67 and cleaved caspase 3 expressions were significantly increased (p<0.05) by H. Pylori infection, and followed by DENA treatment in Gulo−/− mice. Moreover, knockdown of 14-3-3 isoforms (14-3-3ε, 14-3-3σ, 14-3-3ζ and 14-3-3η) were significantly increased sub-G1 phase (characteristics of apoptosis) in AGS cells and, phenotypic changes like cell shrinkage, density and cleaved nuclei were also observed. Proteome analyses showed that 14-3-3σ, 14-3-3η, and tropomyosin alpha-1 chain were down-regulated, and Hspd1 protein and HSC70 were up-regulated after H. Pylori-infection, and followed by DENA. The combined results of immunohistochemistry and proteomic analysis suggest that H. pylori altered the p53 and 14-3-3 isoforms expression and DENA further enhanced the H. pylori effect, which might be involved in carcinogenesis and metastasis of gastric cancer on Gulo−/− mice

Correlation of Radiographic and Patient Assessment of Spine Following Correction of Nonstructural Component in Juvenile Idiopathic Scoliosis

Objective To evaluate the association between progression of curvature of scoliosis, and correction for functional component in patients with juvenile idiopathic scoliosis (JIS). Methods We retrospectively reviewed medical data of patients prescribed custom molded foot orthosis (FO) to correct inequality of RCSPA (resting calcaneal stance position angle), and chose 52 patients (26 females, 26 males) with Cobb angle ≥10° in radiology and uneven pelvic level at iliac crest by different RCSPA (≥3°) as a factor of functional scoliosis. They had different hump angle ≥5° in forward bending test, for idiopathic scoliosis component. Their mean age and mean period of wearing FO were 79.5±10.6 months and 18.6±0.70 months. Results Cobb angle was reduced from 22.03°±4.39° initially to 18.86°±7.53° after wearing FO. Pelvis height difference and RCSPA difference, were reduced from 1.07±0.25 cm initially to 0.60±0.36, and from 4.25°±0.71° initially to 1.71°±0.75° (p<0.01). Cobb angle improved most in 9 months. However, there was no significant improvement for those with more than 25° of Cobb angle initially. Mean Cobb angle improved in all age groups, but patients less than 6 years had clinically significant improvement of more than 5°. Conclusion JIS can have functional components, which should be identified and managed. Foot orthosis is useful in correcting functional factors, in the case of pelvic inequality caused by different RCSPA, for patients with juvenile idiopathic scoliosis

Ethyl acetate fraction from Angelica sinensis inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production

BACKGROUND: The root of Angelica sinensis (AS), also known as "Dang-gui," was a popular herbal medicine widely used in the treatment of gynecological diseases in China, Korea, and Japan for a long time. This study aimed to determine the effects of ethyl acetate fraction from Angelica sinensis (EAAS) on the interleukin-1β (IL-1β)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX) 2, and prostaglandin E2 (PGE2), involved in articular bone and cartilage destruction, by RASFs. RESULTS: RASF proliferation was evaluated with cholecystokinin octapeptide (CCK-8) reagent in the presence of IL-1β with/without EAAS. Expression of MMPs, tissue inhibitor of metalloproteinases-1 (TIMP-1), COXs, PGE2, and intracellular mitogen-activated protein kinase (MAPK) signaling molecules, including p-ERK, p-p38, p-JNK, and NF-κB, were examined using immunoblotting or semi-quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. EAAS inhibited IL-1β-induced RASF proliferation; MMP-1, MMP-3, and COX-2 mRNA and protein expressions; and PGE2 production. EAAS also inhibits the phosphorylation of ERK-1/2, p38, and JNK, and activation of NF-κB by IL-1β. CONCLUSION: EAAS might be a new therapeutic modality for rheumatoid arthritis management