Kinematic Support of a Regular Micro-Relief of a Spherical of a Workpiece By An Embracing Milling

The possibilities of modification of spherical surfaces by cutting and ion-plasma processing with the purpose of improving the quality of machine parts are considered. An analysis of the kinematic features of the treatment of spherical surfaces by a rotating tool at a high cutting speed and the formation of a cutting surface is given. The results of experimental studies of the physical characteristics of the shear layer, microrelief, and microhardness of the resulting surface of the component are presented, including after coating with TiN by an ion-plasma method on a vacuum installation, confirming a decrease in the height of irregularities to Ra 0,6 / 1,2 ?m and increasing microhardness in 1,5 / 3 times in comparison with the traditional methods of obtaining spherical surfaces

Sevanol and Its Analogues: Chemical Synthesis, Biological Effects and Molecular Docking

Among acid-sensing ion channels (ASICs), ASIC1a and ASIC3 subunits are the most widespread and prevalent in physiological and pathophysiological conditions. They participate in synaptic plasticity, learning and memory, as well as the perception of inflammatory and neurological pain, making these channels attractive pharmacological targets. Sevanol, a natural lignan isolated from Thymus armeniacus, inhibits the activity of ASIC1a and ASIC3 isoforms, and has a significant analgesic and anti-inflammatory effect. In this work, we described the efficient chemical synthesis scheme of sevanol and its analogues, which allows us to analyze the structure–activity relationships of the different parts of this molecule. We found that the inhibitory activity of sevanol and its analogues on ASIC1a and ASIC3 channels depends on the number and availability of the carboxyl groups of the molecule. At the structural level, we predicted the presence of a sevanol binding site based on the presence of molecular docking in the central vestibule of the ASIC1a channel. We predicted that this site could also be occupied in part by the FRRF-amide peptide, and the competition assay of sevanol with this peptide confirmed this prediction. The intravenous (i.v.), intranasal (i.n.) and, especially, oral (p.o.) administration of synthetic sevanol in animal models produced significant analgesic and anti-inflammatory effects. Both non-invasive methods of sevanol administration (i.n. and p.o.) showed greater efficacy than the invasive (i.v.) method, thus opening new horizons for medicinal uses of sevanol

Status of NESTOR

NSC KIPT proposed to construct a new X-ray and soft UV source NESTOR with a 40 - 225 MeV electron storage ring in Kharkov. NESTOR is a new type radiation source on the base of Compton scattering and a storage ring. Electrons are injected in the storage ring at 100 MeV and ramped up to final energy of 225 MeV. So, using interaction angle 10 Deg and 150 Deg, the facility covers operation energy range of radiation from soft UV trough synchrotron radiation from bending magnets up to hard X-ray radiation through Compton scattering (.apprx.1 eV .apprx.1 MeV). It is supposed that stored electron beam current will be of about 200 mA. Along with use of Nd:Yag laser of 10 W av. power which was developed by High-Q laser firm and optical resonator with accumulation gain of about 1000 it allows to provide X-ray radiation flux up to 1011 phot/s. NESTOR is the cooperative facility and its development is supported by Ukrainian government and NATO SfP project #977982. It is supposed that NESTOR will be in operation by mid-2007 yr. The status of the project and main facility systems are described in the report