The Kharkov X-ray Generator Facility NESTOR

WEPWA060 - ISBN 978-3-95450-122-9International audienceThe last few years the sources of the X-rays NESTOR based on a storage ring with low beam energy and Compton scattering of intense laser beam are under design and development in NSC KIPT. The main task of the project is to develop compact intense X-ray generator on the base of relatively cheap accelerator equipment and up-to-date laser technologies. The paper is devoted to description of the last results on construction and commissioning of the facility

Progress in Development of Kharkov X-Ray Generator Nestor

The sources of the X-rays based on Compton scattering of intense Nd:YAG laser beam on electron beam circulating in a storage ring with beam energy 43-225 MeV is under construction in NSC KIPT. In the paper the progress in development and construction of Kharkov X-ray generator NESTOR is presented. The current status of the main facility system design and development are described. New scheme and main parameters of injection system are presented. The status of power supply system and control system is described. The facility is going to be in operation in the middle of 2007 and generated X-rays flux is expected to be of about 10{sup 13} phot/s

The start of X-ray generator NESTOR comissioning

The first results of the NESTOR facility commissioning are presented. 60 MeV electron linac injector has been tested and the first electron beam with project parameters was registered at the screen monitors. Electron beam was passed through the transportation channel and injection system. The beamh of electrons was observed and controlled in the screen monitors in the expected range.Перші результати вводу в експлуатацію генератора НЕСТОР представлені. Інжектор-лінійний прискорювач на 60 МеВ електронів був випробуван, та перший пучок із проектними параметрами було зареєстровано на екранах моніторів. Електронний пучок проведено крізь канал транспортування та системи вводу в вакуумну камеру накопичувача. Пучок електронів спостерігається і контролюється на екранах моніторів в очікуваному діапазоні.Представлены первые результаты ввода в эксплуатацию генератора НЕСТОР. Инжектор-линейный ускоритель на 60 МэВ электронов был испытан, и первый пучок с проектными параметрами был зарегистрирован на экранах мониторов. Электронный пучок проведен через канал транспортировки и системы ввода в вакуумную камеру накопителя. Пучок электронов наблюдается и контролируется на экране мониторов в ожидаемом диапазоне

Sevanol and Its Analogues: Chemical Synthesis, Biological Effects and Molecular Docking

Among acid-sensing ion channels (ASICs), ASIC1a and ASIC3 subunits are the most widespread and prevalent in physiological and pathophysiological conditions. They participate in synaptic plasticity, learning and memory, as well as the perception of inflammatory and neurological pain, making these channels attractive pharmacological targets. Sevanol, a natural lignan isolated from Thymus armeniacus, inhibits the activity of ASIC1a and ASIC3 isoforms, and has a significant analgesic and anti-inflammatory effect. In this work, we described the efficient chemical synthesis scheme of sevanol and its analogues, which allows us to analyze the structure–activity relationships of the different parts of this molecule. We found that the inhibitory activity of sevanol and its analogues on ASIC1a and ASIC3 channels depends on the number and availability of the carboxyl groups of the molecule. At the structural level, we predicted the presence of a sevanol binding site based on the presence of molecular docking in the central vestibule of the ASIC1a channel. We predicted that this site could also be occupied in part by the FRRF-amide peptide, and the competition assay of sevanol with this peptide confirmed this prediction. The intravenous (i.v.), intranasal (i.n.) and, especially, oral (p.o.) administration of synthetic sevanol in animal models produced significant analgesic and anti-inflammatory effects. Both non-invasive methods of sevanol administration (i.n. and p.o.) showed greater efficacy than the invasive (i.v.) method, thus opening new horizons for medicinal uses of sevanol

Status of NESTOR

NSC KIPT proposed to construct a new X-ray and soft UV source NESTOR with a 40 - 225 MeV electron storage ring in Kharkov. NESTOR is a new type radiation source on the base of Compton scattering and a storage ring. Electrons are injected in the storage ring at 100 MeV and ramped up to final energy of 225 MeV. So, using interaction angle 10 Deg and 150 Deg, the facility covers operation energy range of radiation from soft UV trough synchrotron radiation from bending magnets up to hard X-ray radiation through Compton scattering (.apprx.1 eV .apprx.1 MeV). It is supposed that stored electron beam current will be of about 200 mA. Along with use of Nd:Yag laser of 10 W av. power which was developed by High-Q laser firm and optical resonator with accumulation gain of about 1000 it allows to provide X-ray radiation flux up to 1011 phot/s. NESTOR is the cooperative facility and its development is supported by Ukrainian government and NATO SfP project #977982. It is supposed that NESTOR will be in operation by mid-2007 yr. The status of the project and main facility systems are described in the report

The Kharkov X-ray Generator Facility NESTOR

WEPWA060 - ISBN 978-3-95450-122-9International audienceThe last few years the sources of the X-rays NESTOR based on a storage ring with low beam energy and Compton scattering of intense laser beam are under design and development in NSC KIPT. The main task of the project is to develop compact intense X-ray generator on the base of relatively cheap accelerator equipment and up-to-date laser technologies. The paper is devoted to description of the last results on construction and commissioning of the facility