12 research outputs found
Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo.
No full textWe report the preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein. These analogues retain the 5,7-dihydroxyisoflavone core of genistein: direct genistein analogues (2-H isoflavones), 2-carboethoxy isoflavones, and the precursor deoxybenzoins were all evaluated. Excellent in vitro activity against Cryptosporidium parvum was observed for both classes of isoflavones in cell cultures, and the lead compound 19, RM6427, shows high in vivo efficacy against an experimental infection
Selective toxicity alteration of a highly toxic antibiotic by an enzyme catalyzing antibiotic modification
No full textUse of nitazoxanide for gastrointestinal tract infections: Treatment of protozoan parasitic infection and beyond
No full textStudies on recovery of lactoferrin from bovine colostrum whey using mercapto ethyl pyridine and phenyl propyl amine HyperCelâ„¢ mixed mode sorbents
No full textElectrochemical and spectral characterization of the host-guest inclusion complex of the antiparasitic drug nitazoxanide with β-cyclodextrin
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Animal models of arthritic disease: influence of novel compared with classical antirheumatic agents
No full textProbing the mesonic structure of the nucleon by means of exclusive quasielastic pion knockout in (e, e′π) reactions at high energies
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