Palladium-catalysed synthesis of imidates, thioimidates and amidines from aryl halides

Palladium-catalysed coupling between aryl- or heteroaryl-bromides, alkoxides, aryloxides or thioalkoxides. and isocyanides gives aryl-imidates and -thioimidates in high yield. Amidines can be synthesised in a one-pot procedure via imidates

Palladium catalysed synthesis of cyclic amidines and imidates

The palladium catalysed insertion of isonitriles into aryl bromides carrying pendant amine or alcohol groups on the ortho position affords cyclic amidines or imidates in good yield

Palladium-catalyzed multicomponent synthesis of 2-aryl-2-imidazolines from aryl halides and diamines

An efficient palladium-catalyzed three-component reaction that combines aryl halides, isocyanides, and diamines provides access to 2-aryl-2-imidazolines in yields up to 96%. Through variation of the diamine component, the reaction can be extended to the synthesis of 2-aryl-1H-benzimidazoles and 2-aryl-1,4,5,6-tetrahydropyrimidines