Performance of TPC crosstalk correction

The performance of the CERN-Dubna-Milano (CDM) algorithm for TPC crosstalk correction is presented. The algorithm is designed to correct for uni-directional and bi-directional crosstalk, but not for self-crosstalk. It reduces at the 10% level the number of clusters, and the number of pads with a signal above threshold. Despite of dramatic effects in selected channels with complicated crosstalk patterns, the average longitudinal signal shape of a hit, and the average transverse signal shape of a cluster, are little affected by uni-directional and bi-directional crosstalk. The longitudinal signal shape of hits is understood in terms of preamplifier response, longitudinal diffusion, track inclination, and self-crosstalk. The transverse signal shape of clusters is understood in terms of the TPC's pad response function. The CDM crosstalk correction leads to an average charge decrease at the level of 15%, though with significant differences between TPC sectors. On the whole, crosstalk constitutes a relatively benign malfunction of the TPC readout which, after correction by the CDM algorithm and with proper attention to self-crosstalk, is not an obstacle to progress with physics analysis

Water data analysis: data reduction from beam and ITC info

After recalling the motivation for the analysis of water data, the first stage of data reduction is discussed. This data reduction is based on the selection of protons using beam detector data and ITC information. The resolution of the interaction time in the target which serves as reference for time-of-flight measurement of secondaries, is determined with stable beam optics to be 77 ps, otherwise 106 ps. Cuts, their selection efficiency, event numbers, purity of the data sample after cuts, and some ITC characteristics are presented

Biochemical and structural insight into the chemical resistance and cofactor specificity of the formate dehydrogenase from Starkeya novella

Formate dehydrogenases (Fdhs) mediate the oxidation of formate to carbon dioxide and concomitant reduction of nicotinamide adenine dinucleotide (NAD + ). The low cost of the substrate formate and importance of the product NADH as a cellular source of reducing power make this reaction attractive for biotechnological applications. However, the majority of Fdhs are sensitive to inactivation by thiol-modifying reagents. In this study, we report a chemically resistant Fdh (Fdh SNO ) from the soil bacterium Starkeya novella strictly specific for NAD + . We present its recombinant overproduction, purification and biochemical characterization. The mechanistic basis of chemical resistance was found to be a valine in position 255 (rather than a cysteine as in other Fdhs) preventing the inactivation by thiol-modifying compounds. To further improve the usefulness of Fdh SNO as for generating reducing power, we rationally engineered the protein to reduce the coenzyme nicotinamide adenine dinucleotide phosphate (NADP + ) with better catalytic efficiency than NAD + . The single mutation D221Q enabled the reduction of NADP + with a catalytic efficiency k CAT /K M of 0.4 s -1 mM -1 at 200 mM formate, while a quadruple mutant (A198G/D221Q/H379K/S380V) resulted in a 5-fold increase in catalytic efficiency for NADP + compared to the single mutant. We determined the cofactor-bound structure of the quadruple mutant to gain mechanistic evidence behind the improved specificity for NADP + . Our efforts to unravel the key residues for the chemical resistance and cofactor specificity of Fdh SNO may lead to wider use of this enzymatic group in a more sustainable (bio)manufacture of value-added chemicals, as for instance the biosynthesis of chiral compounds. </p

Structural insight in the toppling mechanism of an energy-coupling factor transporter

Energy-coupling factor (ECF) transporters mediate uptake of micronutrients in prokaryotes. The transporters consist of an S-component that binds the transported substrate and an ECF module (EcfAA′T) that binds and hydrolyses ATP. The mechanism of transport is poorly understood but presumably involves an unusual step in which the membrane-embedded S-component topples over to carry the substrate across the membrane. In many ECF transporters, the S-component dissociates from the ECF module after transport. Subsequently, substrate-bound S-components out-compete the empty proteins for re-binding to the ECF module in a new round of transport. Here we present crystal structures of the folate-specific transporter ECF–FolT from Lactobacillus delbrueckii. Interaction of the ECF module with FolT stabilizes the toppled state, and simultaneously destroys the high-affinity folate-binding site, allowing substrate release into the cytosol. We hypothesize that differences in the kinetics of toppling can explain how substrate-loaded FolT out-competes apo-FolT for association with the ECF module

Experimental and Numerical Investigations of a Dual-Shaft Test Rig with Intershaft Bearing

This paper deals with an experimental study of a dual rotor test rig. This machine, which was developed and built at the Laboratoire de Tribologie et Dynamique des Systèmes, Ecole Centrale de Lyon, will be first presented. It is composed of two coaxial shafts that are connected by an intershaft bearing and rotate independently, each one driven by its own motor. Their lateral vibrations and whirling motion are coupled by the intershaft bearing. The experimental tests consisting in run-ups and the associated measured unbalance response of the dual rotor will be investigated. The influence of the rotation of each rotor on the critical speeds and the associated amplitudes will be discussed. Moreover, this paper presents a numerical model of the dual rotor. Correlations between the experimental and numerical tests will be investigated. The objective is to be able to predict phenomena observed in experiments, starting from a rather fine numerical model

Revisiting the 'LSND anomaly' II: critique of the data analysis

This paper, together with a preceding paper, questions the so-called 'LSND anomaly': a 3.8 sigma excess of antielectronneutrino interactions over standard backgrounds, observed by the LSND Collaboration in a beam dump experiment with 800 MeV protons. That excess has been interpreted as evidence for the antimuonneutrino to antielectronneutrino oscillation in the \Deltam2 range from 0.2 eV2 to 2 eV2. Such a \Deltam2 range is incompatible with the widely accepted model of oscillations between three light neutrino species and would require the existence of at least one light 'sterile' neutrino. In a preceding paper, it was concluded that the estimates of standard backgrounds must be significantly increased. In this paper, the LSND Collaboration's estimate of the number of antielectronneutrino interactions followed by neutron capture, and of its error, is questioned. The overall conclusion is that the significance of the 'LSND anomaly' is not larger than 2.3 sigma.Comment: 30 pages, 16 figures, 6 table

Why the paper CERN-PH-EP-2009-015 (arXiv:0903.4762) is scientifically unacceptable

The paper CERN-PH-EP-2009-015 (arXiv:0903.4762) by A. Bagulya et al. violates standards of quality of work and scientific ethics on several counts. The paper contains assertions that contradict established detector physics. The paper falls short of proving the correctness of the authors' concepts and results. The paper ignores or quotes misleadingly pertinent published work. The paper ignores the fact that the authors' concepts and results have already been shown wrong in the published literature. The authors seem unaware that cross-section results from the 'HARP Collaboration' that are based on the paper's concepts and algorithms are in gross disagreement with the results of a second analysis of the same data, and with the results of other experiments.Comment: 8 pages, 3 figure

Reply to 'Corrections to the HARP-CDP Analysis of the LSND Neutrino Oscillation Backgrounds'

The alleged mistakes in recent papers that reanalyze the backgrounds to the 'LSND anomaly' do not exist. We maintain our conclusion that the significance of the 'LSND anomaly' is not 3.8 sigma but not larger than 2.3 sigma.Comment: 3 page

Cross-sections of large-angle hadron production in proton- and pion-nucleus interactions VII: tin nuclei and beam momenta from \pm3 GeV/c to \pm15 GeV/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% nuclear interaction length thick stationary tin target, of proton and pion beams with momentum from \pm3 GeV/c to \pm15 GeV/c. Results are given for secondary particles with production angles between 20 and 125 degrees. Cross-sections on tin nuclei are compared with cross-sections on beryllium, carbon, copper, tantalum and lead nuclei.Comment: 68 pages, 13 figure

TPC track distortions III: fiat lux

We present a comprehensive overview and final summary of all four types of static track distortions seen in the HARP TPC, in terms of physical origins, mathematical modelling, and correction algorithms. 'Static'Â distortions are defined as not depending on the event time within the 400 ms long accelerator spill. Calculated static distortions are compared with measurements from cosmic-muon tracks. We characterize track distortions by the r phi residuals of cluster positions with respect to the transverse projection of a helical trajectory constrained by hits in the RPC overlap regions. This method provides a fixed TPC-external reference system (by contrast to the co-moving coordinate system associated with a fit) which solely permits to identify individually, and measure quantitatively, the static TPC track distortions arising from (i) the inhomogeneity of the solenoidal magnetic field, (ii) the inhomogeneity of the electric field from the high-voltage mismatch between the inner and outer TPC field cages, (iii) the anode-wire durchgriff, and (iv) a homogenous ion-charge density in the drift volume. Five voltage levels are identified which were set incorrectly during data taking with the HARP TPC, and unfortunately conspired toward large static and dynamic track distortions. The observed time development of static distortions after a 83mKr calibration lends decisive support to our conclusions on static TPC distortions