Principles and experience of justification of ecological representativeness of Emerald network potential sites

The article presents the results of the multi-method research to provide justification of Emerald network potential site, which meets the requirements of environmental representativeness. Flora and vegetation of the core natural habitat, species composition and prevalence of the species of European importance and from the Red books of the country and region, as well as the habitats of European importance were systematized with the use of methods of botanical and geobotanical studie

Finite momentum superconductivity in superconducting hybrids: Orbital mechanism

Normally in superconductors, as in conductors, in the state with zero current $I$ the momentum of superconducting electrons $\hbar q =0$. Here we demonstrate theoretically and present experimental evidences that in superconducting/normal metal (SN) hybrid strip placed in in-plane magnetic field $B_{in}$ finite momentum state ($\hbar q \neq 0$) is realized when $I=0$. This state is characterized by current-momentum dependence $I(q)\neq -I(-q)$, nonreciprocal kinetic inductance $L_k(I) \neq L_k(-I)$ and different values of depairing currents $I_{dep}^{\pm}$ flowing along the SN strip in opposite directions. Found properties have {\it orbital} nature and are originated from gradient of density of superconducting electrons $\nabla n$ across the thickness of SN strip and field induced Meissner currents. We argue that this type of finite momentum state should be rather general phenomena in superconducting structures with artificial or intrinsic inhomogeneities.Comment: 10 pages, 10 figure

Crude Oil Distillation with Superheated Water Steam: Parametrical Sensitivity and Optimization

Stability of crude oil distillation units was analyzed with mathematical models developed using Aspen Hysys. Parametrical sensitivities of light fractions yields, heat duties and steam load of column trays to perturbations of superheated steam flow rate were estimated. Objective function based on the light products yields and energy consumption for distillation was formed. The maxima of the objective function were calculated depending on operational parameters and flow rate of water steam

Haplotype analysis of APOE intragenic SNPs

BACKGROUND: APOE epsilon4 allele is most common genetic risk factor for Alzheimer\u27s disease (AD) and cognitive decline. However, it remains poorly understood why only some carriers of APOE epsilon4 develop AD and how ethnic variabilities in APOE locus contribute to AD risk. Here, to address the role of APOE haplotypes, we reassessed the diversity of APOE locus in major ethnic groups and in Alzheimer\u27s Disease Neuroimaging Initiative (ADNI) dataset on patients with AD, and subjects with mild cognitive impairment (MCI), and control non-demented individuals. RESULTS: We performed APOE gene haplotype analysis for a short block of five SNPs across the gene using the ADNI whole genome sequencing dataset. The compilation of ADNI data with 1000 Genomes identified the APOE epsilon4 linked haplotypes, which appeared to be distant for the Asian, African and European populations. The common European epsilon4-bearing haplotype is associated with AD but not with MCI, and the Africans lack this haplotype. Haplotypic inference revealed alleles that may confer protection against AD. By assessing the DNA methylation profile of the APOE haplotypes, we found that the AD-associated haplotype features elevated APOE CpG content, implying that this locus can also be regulated by genetic-epigenetic interactions. CONCLUSIONS: We showed that SNP frequency profiles within APOE locus are highly skewed to population-specific haplotypes, suggesting that the ancestral background within different sites at APOE gene may shape the disease phenotype. We propose that our results can be utilized for more specific risk assessment based on population descent of the individuals and on higher specificity of five site haplotypes associated with AD