Development and histogenesis of human foetal lung in relation with gestational age

Background:The objective was to study the development and histogenesis of human foetal lung in relation with different gestational age.Methods:In the present study lung specimens were collected from formalin fixed 27 aborted foetuses (14 male, 13 female) by abdominal dissection between 6 weeks to 40 weeks of gestational age.Results:In the present study we observed that there was a delay in the appearance of embryonic, pseudo glandular phase, canalicular, terminal saccular and alveolar stages of the lung.Conclusion:Delay in the developmental anatomy and histogenesis of the lung cells leads to histopathological abnormalities which gives knowledge to the clinicians during clinical procedures

ANTIHYPERLIPIDEMIC ACTIVITY OF ECLIPTA ALBA IN HIGH FAT DIET-INDUCED HYPERLIPIDEMIC ALBINO RATS

Objective: The objective is to study the antihyperlipidemic activity of Eclipta alba in hyperlipidemic albino rats and the use of herbal plants and their parts such as seeds, berries, leaves, roots, barks, or flowers for the development of drugs for therapeutic purposes which have an effective role in recent years. Methods: A total of 30 adult albino rats of Wistar strain weighing 165–215 g were utilized. Animals were treated with high fat diet for 8 weeks followed by post-treatment of E. alba for 1 week, 2 weeks, and 3 weeks, respectively. After 12 h of fasting on the last day of experiment, serum blood samples were collected in EDTA vials and processed for biochemical analysis. Results: A significant decrease in levels of total cholesterol and triglycerides was noted on animals treated with E. alba compared to high fat diet animals. Treatment of hypercholesterolemic rats with E. alba showed a marked decrease of serum low-density lipoprotein (LDL) and very LDL-cholesterol concentrations compared to the hypercholesterolemic rats. High fat diet feeding worsened the levels of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase enzymes, whereas the same markers were significantly improved by supplementation with E. alba compared to normal group. Conclusion: E. alba acts as antihyperlipidemic agent in hyperlipidemic conditions and helps for better health