Factor Influencing Gender Based Violence Among Pregnant Women Attending Antenatal Clinic in PHC of Syangja District, Nepal

Pregnancy and childbirth were a time of unique vulnerability to violence victimization because of changes in women’s physical, social, emotional, and economic needs during pregnancy. This study aims to determine the factors associated with gender-based violence among pregnant women attending antenatal care clinic (ANC). A cross-sectional study was conducted among 202 pregnant women attend antenatal ward of primary health care centre (PHC) of Syangja district during September 2014 to December 2014 by using semi-structure questionnaire with face to face interviews. SPSS software was used for analysis the data. The prevalence of gender based violence (GBV) among pregnant women was found to be 91.1%. The socio-demographic variables such as ethnicity, religious, the age of respondents, the age of marriage, occupation, and annual income had no association with the experience of different types of GBV (p>0.05). However, there was a statistically association between husband education (p=0.03), the age of marriage (p=0.039) and type of marriage (p=0.013) in case of psychological and economic violence whereas there was no statistically association between with other types of violence. In conclusion, gender based violence during pregnancy was a major prevalent public health problem is Syangja district of Nepal. Focus on age of marriage, types of marriage and education of husband may reduce gender based violence among the pregnant women. Women’s empowerment, economic autonomy, sensitization, awareness and needed of large-scale population-based surveys were the major recommendation of this study

Gene therapy for inherited metabolic diseases

Over the last two decades, gene therapy has been successfully translated to many rare diseases. The number of clinical trials is rapidly expanding and some gene therapy products have now received market authorisation in the western world. Inherited metabolic diseases (IMD) are orphan diseases frequently associated with a severe debilitating phenotype with limited therapeutic perspective. Gene therapy is progressively becoming a diseasechanging therapeutic option for these patients. In this review, we aim to summarise the development of this emerging field detailing the main gene therapy strategies, routes of administration, viral and non-viral vectors and gene editing tools. We discuss the respective advantages and pitfalls of these gene therapy strategies and review their application in IMD, providing examples of clinical trials with lentiviral or adeno-associated viral gene therapy vectors in rare diseases. The rapid development of the field and implementation of gene therapy as a realistic therapeutic option for various IMD in a short term also require a good knowledge and understanding of these technologies from physicians to counsel the patients at best

Understanding the Determinants of User Acceptance of Enterprise Instant Messaging: An Empirical Study

As modern organizations increasingly depend on information systems (IS) to enhance work productivity and seek new business opportunities, communication effectiveness has become one of the key factors that underlie the effective performance of IS implementations and applications. Instant Messaging (IM) presents a revolution in enterprise communication. As more organizations are findings ways to utilize this near-synchronous computing communication technology to enhance communication effectiveness in the workplace, there is a compelling need to understand the factors that are important for the adoption of enterprise IM. We have developed an integrative model based on constructs of the existing IT adoption models as well as theories on motivation, innovation diffusion, and critical mass. Using responses from 140 intended subjects, we have found the results of survey data support the contentions that perceived usefulness, compatibility, enjoyment, and security are significant predictors of intention to use enterprise IM. Although perceived connectivity did not predict the intention directly, it did indirectly through perceived usefulness and perceived ease of use. Implications and future research are discussed

Optical Studies of Zero-Field Magnetization of CdMnTe Quantum Dots: Influence of Average Size and Composition of Quantum Dots

We show that through the resonant optical excitation of spin-polarized excitons into CdMnTe magnetic quantum dots, we can induce a macroscopic magnetization of the Mn impurities. We observe very broad (4 meV linewidth) emission lines of single dots, which are consistent with the formation of strongly confined exciton magnetic polarons. Therefore we attribute the optically induced magnetization of the magnetic dots results to the formation of spin-polarized exciton magnetic polarons. We find that the photo-induced magnetization of magnetic polarons is weaker for larger dots which emit at lower energies within the QD distribution. We also show that the photo-induced magnetization is stronger for quantum dots with lower Mn concentration, which we ascribe to weaker Mn-Mn interaction between the nearest neighbors within the dots. Due to particular stability of the exciton magnetic polarons in QDs, where the localization of the electrons and holes is comparable to the magnetic exchange interaction, this optically induced spin alignment persists to temperatures as high as 160 K.Comment: 26 pages, 7 figs - submitted for publicatio

Fast decay of 23S1 positronium atoms in an MgO lined cavity

We report experiments in which radiatively metastable 2 3S1 positronium (Ps) atoms entered a waveguide whose internal surfaces were lined with smoked magnesium oxide (MgO) powder. The waveguide was built such that time-delayed microwave radiation pulses, tuned to drive 2 3S1 → 2 3P2 transitions, could be applied to the Ps ensemble. The lifetime of 2 3S1 atoms was measured using time-delayed microwave induced decay, yielding ≈ 200 ns. This is considerably shorter than the Zeeman shifted lifetime of 1070 ns, indicating that Ps atoms in the 2 3S1 state do not survive multiple collisions with MgO nanocrystals We report experiments in which radiatively metastable 2 3S1 positronium (Ps) atoms entered a waveguide whose internal surfaces were lined with smoked magnesium oxide (MgO) powder. The waveguide was built such that time-delayed microwave radiation pulses, tuned to drive 2 3S1 → 2 3P2 transitions, could be applied to the Ps ensemble. The lifetime of 2 3S1 atoms was measured using time-delayed microwave induced decay, yielding ≈ 200 ns. This is considerably shorter than the Zeeman shifted lifetime of 1070 ns, indicating that Ps atoms in the 2 3S1 state do not survive multiple collisions with MgO nanocrystal

The exosome journey: from biogenesis to uptake and intracellular signalling.

The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications are generating remarkable interest from the scientific community and investors. Exosomes are small extracellular vesicles secreted by all cell types playing intercellular communication roles in health and disease by transferring cellular cargoes such as functional proteins, metabolites and nucleic acids to recipient cells. An in-depth understanding of exosome biology is therefore essential to ensure clinical development of exosome based investigational therapeutic products. Here we summarise the most up-to-date knowkedge about the complex biological journey of exosomes from biogenesis and secretion, transport and uptake to their intracellular signalling. We delineate the major pathways and molecular players that influence each step of exosome physiology, highlighting the routes of interest, which will be of benefit to exosome manipulation and engineering. We highlight the main controversies in the field of exosome research: their adequate definition, characterisation and biogenesis at plasma membrane. We also delineate the most common identified pitfalls affecting exosome research and development. Unravelling exosome physiology is key to their ultimate progression towards clinical applications. Video Abstract

Community-Based Monitoring of Tigers in Nepal

Local citizens recruited and trained as bagh heralu (“tiger watchers”) helped us to collect information on the distribution of tiger throughout the Terai of Nepal. While the ultimate goal of the bagh heralu program was to map the current metapopulation of tigers in Nepal and to determine extent of breeding outside protected areas, the bagh heralu approach was useful not only because it facilitated data collection but also because it enhanced conservation efforts in multiple ways.Over the five years of the program, bagh heralu became knowledgeable about basic tiger biology and they became recognized in their communities as local tiger experts. Their knowledge of the ecological needs of tigers and strong local interest in the project increased discussions of tiger conservation in local communities throughout the lowlands. This case study indicates that the citizen monitoring programs has the potential to shift some of the responsibility for and economic benefits from biodiversity conservation from government agencies and non-governmental organizations to local communities, thus enhancing efforts to manage resources sustainably across entire landscapes. This case study serves as an example of a citizen monitoring project in a developing country and raises questions relevant to its possible expansion and to broader questions of citizen science in a developing country context