Protein Function Prediction by Integrating Multiple Kernels ∗

Determining protein function constitutes an exercise in integrating information derived from several heterogeneous high-throughput experiments. To utilize the information spread across multiple sources in a combined fashion, these data sources are transformed into kernels. Several protein function prediction methods follow a two-phased approach: they first optimize the weights on individual kernels to produce a composite kernel, and then train a classifier on the composite kernel. As such, these methods result in an optimal composite kernel, but not necessarily in an optimal classifier. On the other hand, some methods optimize the loss of binary classifiers, and learn weights for the different kernels iteratively. A protein has multiple functions, and each function can be viewed as a label. These methods solve the problem of optimizing weights on the input kernels for each of the labels. This is computationally expensive and ignores inter-label correlations. In this paper, we propose a method called Protein Function Prediction by Integrating Multiple Kernels (ProMK). ProMK iteratively optimizes the phases of learning optimal weights and reducing the empirical loss of a multi-label classifier for each of the labels simultaneously, using a combined objective function. ProMK can assign larger weights to smooth kernels and downgrade the weights on noisy kernels. We evaluate the ability of ProMK to predict the function of proteins using several standard benchmarks. We show that our approach performs better than previously proposed protein function prediction approaches that integrate data from multiple networks, and multi-label multiple kernel learning methods.

Study Of Conceptual Design Of The Extension Method For Mechanical Products,

ABSTRACT On the foundation summing up existing intelligent conceptual design method, this paper puts forward the research content, characters, path, and method of the conceptual design of extension for mechanical products. This paper rounds the core technology of intelligent conceptual design to research the modeling method of extension design in function-principlelayout-configuration. It includes the function expression, function decomposition and synthesis, function illation and decision. The computers are utilized to simulate the human dialectic thought when resolve problems in this method. The given example shows that the extension method has been applied in the field of conceptual design for mechanical products. This method has important significance to resolve the bottleneck problem of theory studying and engineering realizing of intelligent CAD

Conditional Adversarial Synthesis of 3D Facial Action Units

Employing deep learning-based approaches for fine-grained facial expression analysis, such as those involving the estimation of Action Unit (AU) intensities, is difficult due to the lack of a large-scale dataset of real faces with sufficiently diverse AU labels for training. In this paper, we consider how AU-level facial image synthesis can be used to substantially augment such a dataset. We propose an AU synthesis framework that combines the well-known 3D Morphable Model (3DMM), which intrinsically disentangles expression parameters from other face attributes, with models that adversarially generate 3DMM expression parameters conditioned on given target AU labels, in contrast to the more conventional approach of generating facial images directly. In this way, we are able to synthesize new combinations of expression parameters and facial images from desired AU labels. Extensive quantitative and qualitative results on the benchmark DISFA dataset demonstrate the effectiveness of our method on 3DMM facial expression parameter synthesis and data augmentation for deep learning-based AU intensity estimation