Cinnamaldehyde regulates mitochondrial quality against hydrogen peroxide induced apoptosis in mouse lung mesenchymal stem cells via the PINK1/Parkin signaling pathway

Background Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease without effective treatments. Mitochondrial dysfunction weakens the ability of mesenchymal stem cells (MSCs) to repair the distal lung epithelium, which is a probable pathogenesis of IPF. In previous research, we found that cinnamaldehyde (CA) can maintain the mitochondrial morphology of MSCs. Methods This present study evaluated the effect and mechanism of CA on murine lung MSCs using the hydrogen peroxide model. Antioxidant effects and mitochondrial function were determined using flow cytometry. The mRNA levels of mitochondrial dynamics and the expressions of autophagy-related proteins were also detected. Results CA can increase the levels of SOD, MMP and ATP, decrease the rate of ROS and apoptosis, and restore the mitochondrial structure. CA can also improve the mRNA expression of MFN1, MFN2, FIS1, DRP1, OPA1, and PGC-1α, increase the expression of LC3 II and p62 and promote the PINK1/Parkin signaling pathway. Our results demonstrated that CA can control mitochondrial quality and avoid apoptosis, which may be associated with the regulation of the PINK1/Parkin signaling pathway

RFA: R-Squared Fitting Analysis Model for Power Attack

Correlation Power Analysis (CPA) introduced by Brier et al. in 2004 is an important method in the side-channel attack and it enables the attacker to use less cost to derive secret or private keys with efficiency over the last decade. In this paper, we propose R-squared fitting model analysis (RFA) which is more appropriate for nonlinear correlation analysis. This model can also be applied to other side-channel methods such as second-order CPA and collision-correlation power attack. Our experiments show that the RFA-based attacks bring significant advantages in both time complexity and success rate

Multiform-based Baduanjin exercise prevention and treatment for idiopathic pulmonary fibrosis: study protocol for a randomized controlled trial

Abstract Introduction In this study, we will combine the traditional Baduanjin with Yijin Jing and Wuqinxi to create an optimized Baduanjin exercise program with three different forms (vertical, sitting, and horizontal) to adapt to idiopathic pulmonary fibrosis (IPF) patients in vairous stages of the disease. The purpose of this study is to explore and compare the therapeutic effects of this multi-form Baduanjin, traditional Baduanjin, and resistance training on lung function and limb motor function in IPF patients. The goal of this study is to prove a novel optimal exercise prescription strategy of Baduanjin exercise for improving and protecting lung function in IPF patients. Methods/design A single-blind and randomized controlled trial is used to conduct this study, while the randomization list will be generated using a computerized random number generator and opaque sealed envelopes with group allocation will be prepared. It will be strictly followed to blind the outcome assessors. and until the experiment’s conclusion, participants won’t know which group they are enrolled in. Patients between the ages of 35 and 80 who have stable diseases and have not regularly practiced Baduanjin exercise in the past will be included. They are divvied up into the following five groups at random: (1) The conventional care group (control group, CG), (2) The traditional Baduanjin exercise group (TG), (3) The modified Baduanjin exercise group (IG), (4) The resistance exercise group (RG) (5) The modified Baduanjin exercise combined with resistance exercise group (IRG). Those CG participants only received the usual treatment, while TC, IG, and RG participants exercised 1 h twice a day for 3 months. MRG participants will have a 3-month intervention with 1 h of Modified Baduanjin Exercise and 1 H of Resistance Training for each day. Every week, all groups underwent will supervis one-day training, with the exception of the control group. The Pulmonary Function Testing (PFT), HRCT, and 6MWT are the main outcome variables. The St. George Respiratory Questionnaire and mMRC are used as secondary outcome measures. Discussion This study may produce a new Baduanjin exercise prescription that is user-friendly, simple to execute, more targeted, and adaptable. Because it consists of three forms, including vertical, sitting, and horizontal, it is more adaptable to the various disease stages and actual situations of IPF patients and may compensate for the shortcomings of conventional pulmonary rehabilitation and traditional Baduanjin. Trial registration Chinese Clinical Trial Registry, ChiCTR2200055559 . Registered on 12 January 2022

Side-Channel Attacks and Countermeasures for Identity-Based Cryptographic Algorithm SM9

Identity-based cryptographic algorithm SM9, which has become the main part of the ISO/IEC 14888-3/AMD1 standard in November 2017, employs the identities of users to generate public-private key pairs. Without the support of digital certificate, it has been applied for cloud computing, cyber-physical system, Internet of Things, and so on. In this paper, the implementation of SM9 algorithm and its Simple Power Attack (SPA) are discussed. Then, we present template attack and fault attack on SPA-resistant SM9. Our experiments have proved that if attackers try the template attack on an 8-bit microcontrol unit, the secret key can be revealed by enabling the device to execute one time. Fault attack even allows the attackers to obtain the 256-bit key of SM9 by performing the algorithm twice and analyzing the two different results. Accordingly, some countermeasures to resist the three kinds of attacks above are given

Impacts of Climate and Land Cover on Soil Organic Carbon in the Eastern Qilian Mountains, China

Soil, as the largest organic carbon pool of terrestrial ecosystem, plays a significant role in regulating the global carbon cycle, atmospheric carbon dioxide (CO2) levels, and global climate change. It is of great significance to scientifically understand the change rule and influence mechanism of soil organic carbon (SOC) to further understand the "source–sink" transformation of SOC and its influence on climate change. In this paper, the spatiotemporal distribution characteristics and influencing mechanism of SOC were analyzed by means of field investigation and laboratory analysis and the measured data in the Eastern Qilian Mountains. The results showed that the average SOC content of 0–50 cm was 35.74 ± 4.15 g/kg and the range of coefficients of variation (CV) between 48.84% and 75.84%, which suggested that the SOC content exhibited moderate heterogeneity at each soil layer of the Eastern Qilian Mountains. In four land cover types, the SOC content of forestland was the highest, followed by alpine meadow, grassland, and wilderness, which presented surface enrichment, and there was a decreasing trend with the soil depth. From the perspective of seasonal dynamics, there was a uniform pattern of SOC content in different land cover types, shown to be the highest in winter, followed by autumn, spring, and summer, and with the biggest difference between winter and summer appearing in the surface layer. At the same time, our study suggested that the SOC content of different land cover types was closely related to aboveground biomass and negatively related to both the mean monthly temperature and the mean monthly precipitation. Therefore, the distribution and variation of SOC was the result of a combination of climate, vegetation, and other factors

The Impacts of Groundwater Chemistry on Wetland Vegetation Distribution in the Northern Qinghai–Tibet Plateau

Groundwater chemistry has an important impact on the vegetation distribution in inland areas. An in-depth understanding of the impact of groundwater chemistry on vegetation can help in developing an effective management strategy to protect the inland ecosystem. The aim of this study was to identify the influence of groundwater chemicals on species diversity and the distribution characteristics of wetland plants at multiple scales based on the groundwater chemical data from 15 sampling points and the distribution data of 13 plants in the Sugan Lake Wetland in 2016. The results show that the groundwater of the Sugan Lake Wetland is weakly alkaline, with high salinity and hardness; the water chemical type is Na-SO4-Cl; the concentration of the major water chemical parameters is significantly different and is the highest in the northwest, followed by the southwest, and is the lowest in the east; with an increase in the groundwater depth, the concentration of major water chemical parameters first showed an increasing trend followed by a decreasing trend; Artemisia frigida Willd, Poa annua L. and Triglochin maritimum L. were adapted to the environment with a higher ion concentration of the groundwater, and their salt resistance was the strongest; Blysmus sinocompressus and Polygonum are more adapted to the environment with lower salinity and hardness of groundwater; Thermopsis lanceolata has stronger adaptability to the ion concentration, salinity, and hardness of groundwater; other plants are adapted to environments where the ion concentration, salinity, and hardness of the groundwater are moderate