Towards a Simple Relationship to Estimate the Capacity of Static and Mobile Wireless Networks

Extensive research has been done on studying the capacity of wireless multi-hop networks. These efforts have led to many sophisticated and customized analytical studies on the capacity of particular networks. While most of the analyses are intellectually challenging, they lack universal properties that can be extended to study the capacity of a different network. In this paper, we sift through various capacity-impacting parameters and present a simple relationship that can be used to estimate the capacity of both static and mobile networks. Specifically, we show that the network capacity is determined by the average number of simultaneous transmissions, the link capacity and the average number of transmissions required to deliver a packet to its destination. Our result is valid for both finite networks and asymptotically infinite networks. We then use this result to explain and better understand the insights of some existing results on the capacity of static networks, mobile networks and hybrid networks and the multicast capacity. The capacity analysis using the aforementioned relationship often becomes simpler. The relationship can be used as a powerful tool to estimate the capacity of different networks. Our work makes important contributions towards developing a generic methodology for network capacity analysis that is applicable to a variety of different scenarios.Comment: accepted to appear in IEEE Transactions on Wireless Communication

A New Cell Association Scheme In Heterogeneous Networks

Cell association scheme determines which base station (BS) and mobile user (MU) should be associated with and also plays a significant role in determining the average data rate a MU can achieve in heterogeneous networks. However, the explosion of digital devices and the scarcity of spectra collectively force us to carefully re-design cell association scheme which was kind of taken for granted before. To address this, we develop a new cell association scheme in heterogeneous networks based on joint consideration of the signal-to-interference-plus-noise ratio (SINR) which a MU experiences and the traffic load of candidate BSs1. MUs and BSs in each tier are modeled as several independent Poisson point processes (PPPs) and all channels experience independently and identically distributed ( i.i.d.) Rayleigh fading. Data rate ratio and traffic load ratio distributions are derived to obtain the tier association probability and the average ergodic MU data rate. Through numerical results, We find that our proposed cell association scheme outperforms cell range expansion (CRE) association scheme. Moreover, results indicate that allocating small sized and high-density BSs will improve spectral efficiency if using our proposed cell association scheme in heterogeneous networks.Comment: Accepted by IEEE ICC 2015 - Next Generation Networking Symposiu

Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica.

Neuromyelitis optica (NMO) is a refractory autoimmune inflammatory disease of the central nervous system without an effective cure. Autologous bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are considered to be promising therapeutic agents for this disease due to their potential regenerative, immune regulatory and neurotrophic effects. However, little is known about the cytological features of BM‑MSCs from patients with NMO, which may influence any therapeutic effects. The present study aimed to compare the proliferation, differentiation and senescence of BM‑MSCs from patients with NMO with that of age‑ and sex‑matched healthy subjects. It was revealed that there were no significant differences in terms of cell morphology or differentiation capacities in the BM‑MSCs from the patients with NMO. However, in comparison with healthy controls, BM‑MSCs derived from the Patients with NMO exhibited a decreased proliferation rate, in addition to a decreased expression of several cell cycle‑promoting and proliferation‑associated genes. Furthermore, the cell death rate increased in BM‑MSCs from patients under normal culture conditions and an assessment of the gene expression profile further confirmed that the BM‑MSCs from patients with NMO were more vulnerable to senescence. Platelet‑derived growth factor (PDGF), as a major mitotic stimulatory factor for MSCs and a potent therapeutic cytokine in demyelinating disease, was able to overcome the decreased proliferation rate and increased senescence defects in BM‑MSCs from the patients with NMO. Taken together, the results from the present study have enabled the proposition of the possibility of combining the application of autologous BM‑MSCs and PDGF for refractory and severe patients with NMO in order to elicit improved therapeutic effects, or, at the least, to include PDGF as a necessary and standard growth factor in the current in vitro formula for the culture of NMO patient‑derived BM‑MSCs