150 research outputs found
Subhealth: definition, criteria for diagnosis and potential prevalence in the central region of China
BACKGROUND: A full evaluation of health conditions is necessary for the effective implementation of public health interventions. However, terms to address the intermediate state between health and disease are lacking, leading the public to overlook this state and thus increasing the risks of developing disease. METHODS: A cross-sectional health survey of 1,473 randomly recruited Chinese Han adults of both sexes living in the central region of China. The criteria for diagnosis of subhealth was defined as the presence of β₯ 1 of the following abnormalities: body mass index β₯ 25 kg/m(2) or waist circumference β₯ 102 cm in men and 88 cm in women; systolic pressure 120β139 mmHg and/or diastolic pressure 80β89 mmHg; serum triglyceride level β₯ 150 mg/dL and/or total cholesterol level β₯ 200 mg/dL and/or high-density lipoprotein cholesterol level < 40 mg/dL in men and 50 mg/dL in women; serum glucose level 110β125 mg/dL; estimated glomerular filtration rate 60β89 ml/min/1.73 m(2); levels of liver enzymes in liver function tests between 41β59 U/L, or with fatty liver disease but < 33% of affected hepatocytes; levels of oxidative stress biomarkers beyond the reference range of 95%; or problems with both sleep quality and psychological state. RESULTS: The prevalences of subhealth and disease in the central region of China were 36.6% and 43.1%, respectively. The prevalence of disease increased from 26.3% in participants aged 20β39 years, to 47.6% and 78.9% for participants aged 40β59 years and those aged 60 years or older, respectively. Compared with participants aged 20β39, the prevalences of health and subhealth in participants aged 60 years or older decreased by 86.7% and 60.3%, respectively. The prevalence of subhealth was increased in association with increases in lifestyle risk scores, while the prevalences of both health and disease were reduced. CONCLUSION: The prevalences of subhealth and disease are high in central China. Subhealth is associated with high lifestyle risk scores. Both the health care sector and the public should pay more attention to subhealth. Lifestyle modifications and/or psychological interventions are needed to ameliorate these conditions
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Comparison of Apparent Diffusion Coefficient and T2 Relaxation Time Variation Patterns in Assessment of Age and Disc Level Related Intervertebral Disc Changes
Purpose To compare the variation patterns of ADC and T2 values in different age and intervertebral disc (IVD) levels, thus to identify their sensitivities in assessing age and disc level related IVDs changes. Materials and Methods The T2 and ADC values were recorded from 345 IVDs of 69 volunteers. Kendall's correlation analysis was used to identify the relationship between age and T2/ADC mean values respectively. The one-way analysis of variance (ANOVA) with post hoc analysis was then applied to test the differences of T2 and ADC values among different IVD levels and age groups, followed by linear regression analysis between age (45 years) and T2/ADC mean values. This study was approved by the Ethics Committee of the Chinese Academy of Medical Sciences and the Peking Union Medical College Hospital. Results: Significant negative correlation was observed between age and T2/ADC mean values. The T2 and ADC values showed significant differences among IVD levels and among age groups except for T2 values in age group 1 (25β34 years) and group 2 (35β44 years), and for ADC values at L1β2 level. Both T2 and ADC values showed significant differences between young (age45 years) at each IVD level. A linear relationship was observed between age and T2/ADC mean values in the elderly group as well as in the young group for the ADC mean values, while no such tendency was identified in the young group for the T2 mean values. Conclusions: ADC values may be a more sensitive parameter than T2 in assessing age and disc level related intervertebral disc changes
Tailoring Dzyaloshinskii-Moriya interaction in a transition metal dichalcogenide by dual-intercalation
Dzyaloshinskii-Moriya interaction (DMI) is vital to form various chiral spin
textures, novel behaviors of magnons and permits their potential applications
in energy-efficient spintronic devices. Here, we realize a sizable bulk DMI in
a transition metal dichalcogenide (TMD) 2H-TaS2 by intercalating Fe atoms,
which form the chiral supercells with broken spatial inversion symmetry and
also act as the source of magnetic orderings. Using a newly developed protonic
gate technology, gate-controlled protons intercalation could further change the
carrier density and intensely tune DMI via the Ruderman-Kittel-Kasuya-Yosida
mechanism. The resultant giant topological Hall resistivity of 1.4 uohm.cm at
-5.2V (about 460% of the zero-bias value) is larger than most of the known
magnetic materials. Theoretical analysis indicates that such a large
topological Hall effect originates from the two-dimensional Bloch-type chiral
spin textures stabilized by DMI, while the large anomalous Hall effect comes
from the gapped Dirac nodal lines by spin-orbit interaction. Dual-intercalation
in 2HTaS2 provides a model system to reveal the nature of DMI in the large
family of TMDs and a promising way of gate tuning of DMI, which further enables
an electrical control of the chiral spin textures and related electromagnetic
phenomena.Comment: 21 pages, 4 figure
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