77 research outputs found
The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment
Hematopoietic stem cells (HSCs) undergo self-renewal and differentiation in the bone marrow, which is tightly regulated by cues from the microenvironment. The gut microbiota, a dynamic community residing on the mucosal surface of vertebrates, plays a crucial role in maintaining host health. Recent evidence suggests that the gut microbiota influences HSCs differentiation by modulating the bone marrow microenvironment through microbial products. This paper comprehensively analyzes the impact of the gut microbiota on hematopoiesis and its effect on HSCs fate and differentiation by modifying the bone marrow microenvironment, including mechanical properties, inflammatory signals, bone marrow stromal cells, and metabolites. Furthermore, we discuss the involvement of the gut microbiota in the development of hematologic malignancies, such as leukemia, multiple myeloma, and lymphoma
Tailoring Dzyaloshinskii-Moriya interaction in a transition metal dichalcogenide by dual-intercalation
Dzyaloshinskii-Moriya interaction (DMI) is vital to form various chiral spin
textures, novel behaviors of magnons and permits their potential applications
in energy-efficient spintronic devices. Here, we realize a sizable bulk DMI in
a transition metal dichalcogenide (TMD) 2H-TaS2 by intercalating Fe atoms,
which form the chiral supercells with broken spatial inversion symmetry and
also act as the source of magnetic orderings. Using a newly developed protonic
gate technology, gate-controlled protons intercalation could further change the
carrier density and intensely tune DMI via the Ruderman-Kittel-Kasuya-Yosida
mechanism. The resultant giant topological Hall resistivity of 1.4 uohm.cm at
-5.2V (about 460% of the zero-bias value) is larger than most of the known
magnetic materials. Theoretical analysis indicates that such a large
topological Hall effect originates from the two-dimensional Bloch-type chiral
spin textures stabilized by DMI, while the large anomalous Hall effect comes
from the gapped Dirac nodal lines by spin-orbit interaction. Dual-intercalation
in 2HTaS2 provides a model system to reveal the nature of DMI in the large
family of TMDs and a promising way of gate tuning of DMI, which further enables
an electrical control of the chiral spin textures and related electromagnetic
phenomena.Comment: 21 pages, 4 figure
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