UAV 3-D path planning based on MOEA/D with adaptive areal weight adjustment

Unmanned aerial vehicles (UAVs) are desirable platforms for time-efficient and cost-effective task execution. 3-D path planning is a key challenge for task decision-making. This paper proposes an improved multi-objective evolutionary algorithm based on decomposition (MOEA/D) with an adaptive areal weight adjustment (AAWA) strategy to make a tradeoff between the total flight path length and the terrain threat. AAWA is designed to improve the diversity of the solutions. More specifically, AAWA first removes a crowded individual and its weight vector from the current population and then adds a sparse individual from the external elite population to the current population. To enable the newly-added individual to evolve towards the sparser area of the population in the objective space, its weight vector is constructed by the objective function value of its neighbors. The effectiveness of MOEA/D-AAWA is validated in twenty synthetic scenarios with different number of obstacles and four realistic scenarios in comparison with other three classical methods.Comment: 23 pages,11 figure

GO-2D: identifying 2-dimensional cellular-localized functional modules in Gene Ontology

BACKGROUND: Rapid progress in high-throughput biotechnologies (e.g. microarrays) and exponential accumulation of gene functional knowledge make it promising for systematic understanding of complex human diseases at functional modules level. Based on Gene Ontology, a large number of automatic tools have been developed for the functional analysis and biological interpretation of the high-throughput microarray data. RESULTS: Different from the existing tools such as Onto-Express and FatiGO, we develop a tool named GO-2D for identifying 2-dimensional functional modules based on combined GO categories. For example, it refines biological process categories by sorting their genes into different cellular component categories, and then extracts those combined categories enriched with the interesting genes (e.g., the differentially expressed genes) for identifying the cellular-localized functional modules. Applications of GO-2D to the analyses of two human cancer datasets show that very specific disease-relevant processes can be identified by using cellular location information. CONCLUSION: For studying complex human diseases, GO-2D can extract functionally compact and detailed modules such as the cellular-localized ones, characterizing disease-relevant modules in terms of both biological processes and cellular locations. The application results clearly demonstrate that 2-dimensional approach complementary to current 1-dimensional approach is powerful for finding modules highly relevant to diseases

Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine

Species in the ascomycete fungal genus Cordyceps have been proposed to be the teleomorphs of Metarhizium species. The latter have been widely used as insect biocontrol agents. Cordyceps species are highly prized for use in traditional Chinese medicines, but the genes responsible for biosynthesis of bioactive components, insect pathogenicity and the control of sexuality and fruiting have not been determined. Here, we report the genome sequence of the type species Cordyceps militaris. Phylogenomic analysis suggests that different species in the Cordyceps/Metarhizium genera have evolved into insect pathogens independently of each other, and that their similar large secretomes and gene family expansions are due to convergent evolution. However, relative to other fungi, including Metarhizium spp., many protein families are reduced in C. militaris, which suggests a more restricted ecology. Consistent with its long track record of safe usage as a medicine, the Cordyceps genome does not contain genes for known human mycotoxins. We establish that C. militaris is sexually heterothallic but, very unusually, fruiting can occur without an opposite mating-type partner. Transcriptional profiling indicates that fruiting involves induction of the Zn2Cys6-type transcription factors and MAPK pathway; unlike other fungi, however, the PKA pathway is not activated.https://doi.org/10.1186/gb-2011-12-11-r11

High Internal Phase Pickering Emulsion Stabilized by Natural Biomacromolecules and Its Application in Foods

In recent years, high internal phase Pickering emulsions (HIPPEs) has attracted much attention due to its unique organizational properties and has a wide application prospect in the food field. Natural biomacromolecules, active components in organisms, possess good biocompatibility, degradability, no or low toxic effects, which are excellent stabilizers for HIPPEs. In this paper, the potential of natural biomacromolecules to stabilize HIPPEs and recent progress on the application of biopolymer-stabilized HIPPEs in the inhibition of lipid oxidation, as a substitute for trans fatty acids, and in the encapsulation and delivery of nutrients, the 3D printing of foods and encapsulation of probiotics are briefly reviewed in order to provide a reference for the application of HIPPEs stabilized by natural biomacromolecules in foods