Transmission of doughnut light through a bull's eye structure

We experimentally investigate the extraordinary optical transmission of doughnut light through a bull's eye structure. Since the intensity is vanished in the center of the beam, almost all the energy reaches the circular corrugations (not on the hole), excite surface plasmons which propagate through the hole and reradiate photons. The transmitted energy is about 57 times of the input energy on the hole area. It is also interesting that the transmitted light has a similar spatial shape with the input light although the diameter of the hole is much smaller than the wavelength of light.Comment: 3 pages,4 figure

Effect of gate voltage on spin transport along α\alpha-helical protein

Recently, the chiral-induced spin selectivity in molecular systems has attracted extensive interest among the scientific communities. Here, we investigate the effect of the gate voltage on spin-selective electron transport through the $\alpha$-helical peptide/protein molecule contacted by two nonmagnetic electrodes. Based on an effective model Hamiltonian and the Landauer-B\"uttiker formula, we calculate the conductance and the spin polarization under an external electric field which is perpendicular to the helix axis of the $\alpha$-helical peptide/protein molecule. Our results indicate that both the magnitude and the direction of the gate field have a significant effect on the conductance and the spin polarization. The spin filtration efficiency can be improved by properly tuning the gate voltage, especially in the case of strong dephasing regime. And the spin polarization increases monotonically with the molecular length without the gate voltage, which is consistent with the recent experiment, and presents oscillating behavior in the presence of the gate voltage. In addition, the spin selectivity is robust against the dephasing, the on-site energy disorder, and the space angle disorder under the gate voltage. Our results could motivate further experimental and theoretical works on the chiral-based spin selectivity in molecular systems.Comment: 8 pages, 7 figure

Chatbots in Drug Discovery: A Case Study on Anti-Cocaine Addiction Drug Development with ChatGPT

The birth of ChatGPT, a cutting-edge language model chatbot developed by OpenAI, ushered in a new era in AI, and this paper vividly showcases its innovative application within the field of drug discovery. Focused specifically on developing anti-cocaine addiction drugs, the study employs GPT-4 as a virtual guide, offering strategic and methodological insights to researchers working on generative models for drug candidates. The primary objective is to generate optimal drug-like molecules with desired properties. By leveraging the capabilities of ChatGPT, the study introduces a novel approach to the drug discovery process. This symbiotic partnership between AI and researchers transforms how drug development is approached. Chatbots become facilitators, steering researchers towards innovative methodologies and productive paths for creating effective drug candidates. This research sheds light on the collaborative synergy between human expertise and AI assistance, wherein ChatGPT's cognitive abilities enhance the design and development of potential pharmaceutical solutions. This paper not only explores the integration of advanced AI in drug discovery but also reimagines the landscape by advocating for AI-powered chatbots as trailblazers in revolutionizing therapeutic innovation

Enhancing the machine vision performance with multi-spectral light sources

This study mainly focuses on the performance of different multi-spectral light sources on different object colors in machine vision and tries to enhance machine vision with multi-spectral light sources. Using different color pencils as samples, by recognizing the collected images with two classical neural networks, AlexNet and VGG19, the performance was investigated under 35 different multi-spectral light sources. The results show that for both models there are always some non-pure white light sources, whose accuracy is better than pure white light, which suggests the potential of multi-spectral light sources to further enhance the effectiveness of machine vision. The comparison of both models is also performed, and surprised to find that the overall performance of VGG19 is lower than that of AlexNet, which shows that the importance of the choice of multi-spectral light sources and models.Comment: 12 pages, 7 figure

Coupling of light from an optical fiber taper into silver nanowires

We report the coupling of photons from an optical fiber taper to surface plasmon modes of silver nanowires. The launch of propagating plasmons can be realized not only at ends of the nanowires, but also at the midsection. The degree of the coupling can be controlled by adjusting the light polarization. In addition, we present the coupling of light into multiple nanowires from a single optical fiber taper simultaneously. Our demonstration offers a novel method for optimizing plasmon coupling into nanoscale metallic waveguides and promotes the realization of highly integrated plasmonic devices.Comment: 5 pages, 4 figure