The disruption of proteostasis in neurodegenerative diseases

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio

Advances in anisotropy of plastic behaviour and formability of sheet metals

This paper reviews the most recent models for description of the anisotropic plastic behavior and formability of sheet metals. After a brief review of classic isotropic yield functions, recent advanced anisotropic criteria for polycrystalline materials of various crystal structures and their applications to cup drawing are presented. Next, the discussion focuses on novel formulations of anisotropic hardening. A brief review of the experimental methods used for characterizing and modeling the anisotropic plastic behavior of metallic sheets and tubes under biaxial loading is presented. The experimental methods and theoretical models used for measuring and predicting the limit strains, development of new tests for determining the Forming Limit Curves (FLC), as well as on studying the influence of various material or process parameters on the limit strains are presented.11Nsciescopu