A reversal coarse-grained analysis with application to an altered functional circuit in depression

Introduction: When studying brain function using functional magnetic resonance imaging (fMRI) data containing tens of thousands of voxels, a coarse-grained approach – dividing the whole brain into regions of interest – is applied frequently to investigate the organization of the functional network on a relatively coarse scale. However, a coarse-grained scheme may average out the fine details over small spatial scales, thus rendering it difficult to identify the exact locations of functional abnormalities. Methods: A novel and general approach to reverse the coarse-grained approach by locating the exact sources of the functional abnormalities is proposed. Results: Thirty-nine patients with major depressive disorder (MDD) and 37 matched healthy controls are studied. A circuit comprising the left superior frontal gyrus (SFGdor), right insula (INS), and right putamen (PUT) exhibit the greatest changes between the patients with MDD and controls. A reversal coarse-grained analysis is applied to this circuit to determine the exact location of functional abnormalities. Conclusions: The voxel-wise time series extracted from the reversal coarse-grained analysis (source) had several advantages over the original coarse-grained approach: (1) presence of a larger and detectable amplitude of fluctuations, which indicates that neuronal activities in the source are more synchronized; (2) identification of more significant differences between patients and controls in terms of the functional connectivity associated with the sources; and (3) marked improvement in performing discrimination tasks. A software package for pattern classification between controls and patients is available in Supporting Information

Quark Condensates in Nuclear Matter in the Global Color Symmetry Model of QCD

With the global color symmetry model being extended to finite chemical potential, we study the density dependence of the local and nonlocal scalar quark condensates in nuclear matter. The calculated results indicate that the quark condensates increase smoothly with the increasing of nuclear matter density before the critical value (about 12$\rho_0$) is reached. It also manifests that the chiral symmetry is restored suddenly as the density of nuclear matter reaches its critical value. Meanwhile, the nonlocal quark condensate in nuclear matter changes nonmonotonously against the space-time distance among the quarks.Comment: 15 pages, 3 figure