Empathic Communication and Artistic Healing Role of Local Music in Xiamen City under Major Social Events

From local to global, from individual to universal, from singularity to plurality, music not only promotes the deep integration and dissemination of urban culture, giving birth to the theoretical perspective of “music studies”, but also becomes an important symbol and weathervane of a city’s cultural trend. Whether it is a metropolis such as London, Paris or Beijing, or an art city that focuses on the city’s on-the-ground music creation or identity, music is closely connected to the urban cultural space. At the same time, music is also a “holistic effect art”, a language of cultural globalisation. This study will be based on the creation and dissemination of Xiamen’s urban music works under major social issues, taking aesthetic function and artistic healing as the entry point, combining with the case study of Xiamen’s urban in situ music works to explore the current situation of the creation and dissemination of its works, elucidating the social value and artistic healing function of the city’s songs, and rethinking and exploring the relationship between literary and artistic works and the harmonious development of the human society, and the role of the city’s brand shaping and influence on city branding. This research will mainly focus on the literature research method and case study method, using the Internet and electronic resource databases to review the literature, understand the knowledge related to music and art, clarify the development of urban local music and the current status of research, and obtain relevant research information, so as to provide ideas and references for the project research. To analyse the data of urban local music creation and dissemination with appropriate statistical and analytical methods, in order to maximise the function of the data and play a role in the data. Take urban local music as a typical case, investigate it, and give solution ideas and programmes, and look forward to the direction of creation and dissemination of contemporary literary works of urban local music under major social events

CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt

Cell survival depends on proper propagation of protective signals through intracellular signaling intermediates. We report here that calponin homology domain–containing integrin-linked kinase (ILK)–binding protein (CH-ILKBP), a widely expressed adaptor protein localized at plasma membrane-actin junctions, is essential for transmission of survival signals. Cells that are depleted of CH-ILKBP undergo extensive apoptosis despite the presence of cell–extracellular matrix contacts and soluble growth factors. The activating phosphorylation of protein kinase B (PKB/Akt), a key regulator of apoptosis, is impaired in the absence of CH-ILKBP. Importantly, loss of CH-ILKBP prevents the membrane translocation of PKB/Akt. Furthermore, forced membrane targeting of PKB/Akt bypasses the requirement of CH-ILKBP for the activating phosphorylation of PKB/Akt, suggesting that CH-ILKBP is required for the membrane translocation but not the subsequent phosphorylation of PKB/Akt. Finally, we show that loss of CH-ILKBP is also required for the full activation of extracellular signal–regulated kinase (ERK)1/2. However, restoration of the PKB/Akt activation is sufficient for protection of cells from apoptosis induced by the depletion of CH-ILKBP despite the persistent suppression of the ERK1/2 activation. Thus, CH-ILKBP is an important component of the prosurvival signaling pathway functioning primarily by facilitating the membrane translocation of PKB/Akt and consequently the activation of PKB/Akt in response to extracellular survival signals

Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes.

The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity. Understanding their regulation might provide new opportunities for therapeutic interventions, but the molecular mechanism(s) coordinating relaxin expression in the heart remain largely obscured. Previous work demonstrated a role for the orphan nuclear receptor Nur77 in regulating cardiomyocyte apoptosis. We therefore investigated Nur77 in the hopes of identifying novel relaxin regulators. Quantitative real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) data indicated that ectopic expression of orphan nuclear receptor Nur77 markedly increased the expression of latexin-3 (RLN3), but not relaxin-1 (RLN1), in neonatal rat ventricular cardiomyocytes (NRVMs). Furthermore, we found that the -adrenergic agonist isoproterenol (ISO) markedly stimulated RLN3 expression, and this stimulation was significantly attenuated in Nur77 knockdown cardiomyocytes and Nur77 knockout hearts. We showed that Nur77 significantly increased RLN3 promoter activity via specific binding to the RLN3 promoter, as demonstrated by electrophoretic mobility shift assay (EMSA) and chromatin immuno-precipitation (ChIP) assays. Furthermore, we found that Nur77 overexpression potently inhibited ISO-induced cardiomyocyte apoptosis, whereas this protective effect was significantly attenuated in RLN3 knockdown cardiomyocytes, suggesting that Nur77-induced RLN3 expression is an important mediator for the suppression of cardiomyocyte apoptosis. These findings show that Nur77 regulates RLN3 expression, therefore suppressing apoptosis in the heart, and suggest that activation of Nur77 may represent a useful therapeutic strategy for inhibition of cardiac fibrosis and heart failure. © 2018 You et al

Modal analysis of micro wind turbine blade using COSMOSWorks

In this paper, vibration modal analysis of a horizontal axis micro wind turbine blade of different rotational speeds was carried out by using the finite element analysis software COSMOSWorks. The dynamic stiffening phenomenon and its effect on the vibration mode of the wind turbine blade were taken into account. Numerical results were analyzed and compared. The analysis can help not only to ensure the reliability of system operation but also to improve the structural performance

The Composite Face Effect Between Young and Older Chinese Adults Remains Stable

Holistic face perception is often considered to be a cornerstone of face processing. However, the development of the ability to holistically perceive faces in East Asian individuals is unclear. Therefore, we measured and compared holistic face processing in groups of Chinese children, young adults, and older adults by employing the complete composite face paradigm. The results demonstrate a similar magnitude of the composite effect in all three groups although face recognition performance in the task was better in young adults than in the two other groups. These findings suggest that holistic face perception in Eastern individuals is stable from late childhood to at least age 60, whereas face memory may be subject to later development and earlier decline.Peer Reviewe