4 research outputs found
COVCOG 1: Factors Predicting Physical, Neurological and Cognitive Symptoms in Long COVID in a Community Sample. A First Publication From the COVID and Cognition Study
Since its first emergence in December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has evolved into a global pandemic. Whilst often considered a respiratory disease, a large proportion of COVID-19 patients report neurological symptoms, and there is accumulating evidence for neural damage in some individuals, with recent studies suggesting loss of gray matter in multiple regions, particularly in the left hemisphere. There are a number of mechanisms by which COVID-19 infection may lead to neurological symptoms and structural and functional changes in the brain, and it is reasonable to expect that many of these may translate into cognitive problems. Indeed, cognitive problems are one of the most commonly reported symptoms in those experiencing “Long COVID”—the chronic illness following COVID-19 infection that affects between 10 and 25% of patients. The COVID and Cognition Study is a part cross-sectional, part longitudinal, study documenting and aiming to understand the cognitive problems in Long COVID. In this first paper from the study, we document the characteristics of our sample of 181 individuals who had experienced COVID-19 infection, and 185 who had not. We explore which factors may be predictive of ongoing symptoms and their severity, as well as conducting an in-depth analysis of symptom profiles. Finally, we explore which factors predict the presence and severity of cognitive symptoms, both throughout the ongoing illness and at the time of testing. The main finding from this first analysis is that that severity of initial illness is a significant predictor of the presence and severity of ongoing symptoms, and that some symptoms during the initial illness—particularly limb weakness—may be more common in those that have more severe ongoing symptoms. Symptom profiles can be well described in terms of 5 or 6 factors, reflecting the variety of this highly heterogenous condition experienced by the individual. Specifically, we found that neurological/psychiatric and fatigue/mixed symptoms during the initial illness, and that neurological, gastrointestinal, and cardiopulmonary/fatigue symptoms during the ongoing illness, predicted experience of cognitive symptoms.</jats:p
COVCOG 2: Cognitive and Memory Deficits in Long COVID: A Second Publication From the COVID and Cognition Study.
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been often characterized as a respiratory disease. However, it is increasingly being understood as an infection that impacts multiple systems, and many patients report neurological symptoms. Indeed, there is accumulating evidence for neural damage in some individuals, with recent studies suggesting loss of gray matter in multiple regions, particularly in the left hemisphere. There are several mechanisms by which the COVID-19 infection may lead to neurological symptoms and structural and functional changes in the brain, and cognitive problems are one of the most commonly reported symptoms in those experiencing Long COVID - the chronic illness following the COVID-19 infection that affects between 10 and 25% of patients. However, there is yet little research testing cognition in Long COVID. The COVID and Cognition Study is a cross-sectional/longitudinal study aiming to understand cognitive problems in Long COVID. The first paper from the study explored the characteristics of our sample of 181 individuals who had experienced the COVID-19 infection, and 185 who had not, and the factors that predicted ongoing symptoms and self-reported cognitive deficits. In this second paper from the study, we assess this sample on tests of memory, language, and executive function. We hypothesize that performance on "objective" cognitive tests will reflect self-reported cognitive symptoms. We further hypothesize that some symptom profiles may be more predictive of cognitive performance than others, perhaps giving some information about the mechanism. We found a consistent pattern of memory deficits in those that had experienced the COVID-19 infection, with deficits increasing with the severity of self-reported ongoing symptoms. Fatigue/Mixed symptoms during the initial illness and ongoing neurological symptoms were predictive of cognitive performance
Recommended from our members
Factors Affecting Episodic Memory Development
The present thesis investigated the development of episodic memory through middle and late childhood, and how individual differences in health and lifestyle impact this development. The first study (Chapter 2) explored the developmental patterns of episodic memory including individual content elements (what, where and when) and integrated what-where-when (WWW) representation on British children aged 6-12. Results suggest that episodic memory continues to develop during this period, with item, spatial, temporal and WWW memory all improving relatively linearly with age. These improvements are driven by both associative binding and strategic control abilities. The second study (Chapter 3) extended this work by additionally exploring how variation in encoding and strategy use influences memory development in a slightly older age range of 8-13. While associative and strategic retrieval abilities showed improvement with age, strategic encoding ability seemed to stay relatively stable across this period of late childhood. Regarding the effect of strategy use, older children produced and noticed more strategies than younger children, but only the younger children benefitted more from noticing the strategies. The third study (Chapter 4) extended the developmental pattern to a diverse population by replicating the experiment with a sample of Chinese children aged 8-10. Results from Chapters 3 and 4 also indicate that executive function is likely to play a critical role in memory development. The fourth study (Chapter 5) investigated the influences of health and lifestyle factors, with particular emphasis on diet and physical activity, on memory development. The fifth study (Chapter 6) went further in trying to understand how cross-cultural differences in lifestyle may contribute to different patterns of memory development. Results from Chapters 5 and 6 suggest that individual differences in diet and exercise are linked with detectable differences in memory development, and that these effects may not be mediated by executive function. Collectively, the findings of this thesis shed light on a general pattern of episodic memory development over diverse populations across different cultures, and highlight the importance of a healthy lifestyle in promoting children’s cognitive and memory development.China Scholarship Council (CSC
Recommended from our members
Episodic memory during middle childhood: What is developing?
Whereas previous research has concentrated on the emergence of episodic memory during the early years, fewer investigations have explored the details of this development through middle and late childhood. Considerable variation in task demands and testing methodologies have rendered the trajectory of episodic memory during this period unclear, particularly with regard to which elements are in a state of change at which time. This study separately assessed memory for item, location, and temporal order, as well as integrated what-where-when (WWW) information using a WWW memory test (the Treasure Hunt task), with 84 children aged 6 to 12Â years. Two versions of the task were used, varying in the degree of retrieval support while keeping encoding constant. Results show that episodic memory continued to develop across this period, with individual item, spatial, temporal, and WWW memory all improving relatively linearly with age. These improvements were underpinned by both the associative binding and strategic control processes. These findings suggest that it is not any one element of episodic memory that is driving development during this period but that all aspects are continuing to mature in parallel