Echocardiographic evaluation of velocity ratio, velocity time integral ratio, and pulmonary valve area in dogs with pulmonary valve stenosis.

BackgroundVelocity ratio, velocity time integral (VTI) ratio, and pulmonary valve area indexed to body surface area (iPVA) are methods of assessment of pulmonary valve stenosis (PS) severity that are less dependent on blood flow. Studies evaluating these methods are limited.ObjectivesTo determine the effects of butorphanol, atenolol, and balloon valvuloplasty (BV) on velocity ratio, VTI ratio, iPVA, mean PG, and max PG.AnimalsTwenty-seven dogs with PS (max PG >50 mm Hg).MethodsProspective study. All dogs underwent an echocardiogram at baseline, 5-minutes after administration of butorphanol (0.2-0.25 mg/kg IV), and 2-to-4 weeks after atenolol (1-1.5 mg/kg q12h). Twenty-one of these were evaluated 24-hours after BV.ResultsThere were no significant differences (P > .05) amongst any of the methods of assessment of PS severity after butorphanol. After atenolol, mean (SD) of mean (57.0 [21.0] mm Hg) and max PG (93.1 [33.8] mm Hg) were significantly decreased (P ≤ .047) compared with baseline (65.2 [26.2] mm Hg and 108 [44.4] mm Hg, respectively). After atenolol, there were no significant (P ≥ .12) differences in velocity ratio (0.29 [0.09]), VTI ratio (0.18 [0.05]), or iPVA (0.43 [0.16] cm2 /m2 ) compared with baseline (0.30 [0.09], 0.19 [0.09], 0.44 [0.17] cm2 /m2 , respectively).Conclusions and clinical importanceAtenolol might reduce mean and max PG but does not alter less flow-dependent methods of assessment of PS severity (velocity ratio, VTI ratio, and iPVA) in dogs with PS. Results support an integrative approach to assessment of PS severity that includes less flow-dependent methods, particularly in states of altered flow or right ventricular function

Towards the QCD phase diagram from analytical continuation

We calculate the QCD cross-over temperature, the equation of state and fluctuations of conserved charges at finite density by analytical continuation from imaginary to real chemical potentials. Our calculations are based on new continuum extrapolated lattice simulations using the 4stout staggered actions with a lattice resolution up to $N_t=16$. The simulation parameters are tuned such that the strangeness neutrality is maintained, as it is in heavy ion collisions.Comment: 4 pages, 2 figures, Proceedings of the Quark Matter 2015 conference, Kobe, Japa

The calibration of photographic and spectroscopic films: Reciprocity failure and thermal responses of IIaO film at liquid nitrogen temperatures

Reciprocity failure was examined for IIaO spectroscopic film. The results indicate reciprocity failure occurs at three distinct minimum points in time; 15 min, 30 min and 90 min. The results are unique because theory suggests only one minimum reciprocity failure point should occur. When incubating 70mm IIaO film for 15 and 30 min at temperatures of 30, 40, 50, and 60 C and then placing in a liquid nitrogen bath at a temperature of -190 C the film demonstrated an increase of the optical density when developed at a warm-up time of 30 min. Longer warm-up periods of 1, 2 and 3 hrs yield a decrease in optical density of the darker wedge patterns; whereas, shorter warm-up times yield an overall increase in the optical densities

Aberrant migration and surgical removal of a heartworm (Dirofilaria immitis) from the femoral artery of a cat.

A cat was evaluated for an acute-onset of right pelvic limb paresis. Thoracic radiographs revealed normal cardiac size and tortuous pulmonary arteries. Abdominal ultrasound identified a heartworm (HW) extending from the caudal abdominal aorta into the right external iliac artery and right femoral artery. The cat was HW-antigen positive. Echocardiography revealed a HW within the right branch of the main pulmonary artery and evidence of pulmonary hypertension. An agitated-saline contrast echocardiogram revealed a small right to left intracardiac shunt at the level of the atria. Surgical removal of the HW was performed with no substantial postoperative complications. There was return of blood flow and improved motor function to the limb. The cat remains mildly paretic on the affected limb with no other clinical signs

The Intrinsic Two-Dimensional Size of Sagittarius A*

We report the detection of the two-dimensional structure of the radio source associated with the Galactic Center black hole, Sagittarius A*, obtained from Very Long Baseline Array (VLBA) observations at a wavelength of 7mm. The intrinsic source is modeled as an elliptical Gaussian with major axis size 35.4 x 12.6 R_S in position angle 95 deg East of North. This morphology can be interpreted in the context of both jet and accretion disk models for the radio emission. There is supporting evidence in large angular-scale multi-wavelength observations for both source models for a preferred axis near 95 deg. We also place a maximum peak-to-peak change of 15% in the intrinsic major axis size over five different epochs. Three observations were triggered by detection of near infrared (NIR) flares and one was simultaneous with a large X-ray flare detected by NuSTAR. The absence of simultaneous and quasi-simultaneous flares indicates that not all high energy events produce variability at radio wavelengths. This supports the conclusion that NIR and X-ray flares are primarily due to electron excitation and not to an enhanced accretion rate onto the black hole.Comment: accepted for publication in Ap

Low-Temperature Quantum Relaxation in a System of Magnetic Nanomolecules

We argue that to explain recent resonant tunneling experiments on crystals of Mn$_{12}$ and Fe$_8$, particularly in the low-T limit, one must invoke dynamic nuclear spin and dipolar interactions. We show the low-$T$, short-time relaxation will then have a $\sqrt{t/\tau}$ form, where $\tau$ depends on the nuclear $T_2$, on the tunneling matrix element $\Delta_{10}$ between the two lowest levels, and on the initial distribution of internal fields in the sample, which depends very strongly on sample shape. The results are directly applicable to the $Fe_8$ system. We also give some results for the long-time relaxation.Comment: 4 pages, 3 PostScript figures, LaTe

An alternate model for magnetization plateaus in the molecular magnet V_15

Starting from an antiferromagnetic Heisenberg Hamiltonian for the fifteen spin-1/2 ions in V_15, we construct an effective spin Hamiltonian involving eight low-lying states (spin-1/2 and spin-3/2) coupled to a phonon bath. We numerically solve the time-dependent Schrodinger equation of this system, and obtain the magnetization as a function of temperature in a time-dependent magnetic field. The magnetization exhibits unusual patterns of hysteresis and plateaus as the field sweep rate and temperature are varied. The observed plateaus are not due to quantum tunneling but are a result of thermal averaging. Our results are in good agreement with recent experimental observations.Comment: Revtex, 4 pages, 5 eps figure

Moduli Stabilization in Brane Gas Cosmology with Superpotentials

In the context of brane gas cosmology in superstring theory, we show why it is impossible to simultaneously stabilize the dilaton and the radion with a general gas of strings (including massless modes) and D-branes. Although this requires invoking a different mechanism to stabilize these moduli fields, we find that the brane gas can still play a crucial role in the early universe in assisting moduli stabilization. We show that a modest energy density of specific types of brane gas can solve the overshoot problem that typically afflicts potentials arising from gaugino condensation.Comment: minor changes to match the journal versio

Anisotropic Inflation and the Origin of Four Large Dimensions

In the context of (4+d)-dimensional general relativity, we propose an inflationary scenario wherein 3 spatial dimensions grow large, while d extra dimensions remain small. Our model requires that a self-interacting d-form acquire a vacuum expectation value along the extra dimensions. This causes 3 spatial dimensions to inflate, whilst keeping the size of the extra dimensions nearly constant. We do not require an additional stabilization mechanism for the radion, as stable solutions exist for flat, and for negatively curved compact extra dimensions. From a four-dimensional perspective, the radion does not couple to the inflaton; and, the small amplitude of the CMB temperature anisotropies arises from an exponential suppression of fluctuations, due to the higher-dimensional origin of the inflaton. The mechanism triggering the end of inflation is responsible, both, for heating the universe, and for avoiding violations of the equivalence principle due to coupling between the radion and matter.Comment: 24 pages, 2 figures; uses RevTeX4. v2: Minor changes and added references. v3: Improved discussion of slow-rol