Multiple Degradation Skilled Network for Infrared and Visible Image Fusion Based on Multi-Resolution SVD Updation

Existing infrared (IR)-visible (VIS) image fusion algorithms demand source images with the same resolution levels. However, IR images are always available with poor resolution due to hardware limitations and environmental conditions. In this correspondence, we develop a novel image fusion model that brings resolution consistency between IR-VIS source images and generates an accurate high-resolution fused image. We train a single deep convolutional neural network model by considering true degradations in real time and reconstruct IR images. The trained multiple degradation skilled network (MDSNet) increases the prominence of objects in fused images from the IR source image. In addition, we adopt multi-resolution singular value decomposition (MRSVD) to capture maximum information from source images and update IR image coefficients with that of VIS images at the finest level. This ensures uniform contrast along with clear textural information in our results. Experiments demonstrate the efficiency of the proposed method over nine state-of-the-art methods using five image quality assessment metrics

Dabrafenib-Panobinostat Salt: Improving Dissolution Rate and Inhibition of BRAF Melanoma Cells

Cocrystallization of the drug−drug salt-cocrystal of the histone deacetylase inhibitor (HDACi) panobinostat (PAN) and b-rapidly accelerated fibrosarcoma (BRAF) inhibitor dabrafenib (DBF) afforded single crystals of a two-drug salt stabilized by N+−H···O and N+−H···N− hydrogen bonds between the ionized panobinostat ammonium donor and dabrafenib sulfonamide anion acceptor in a 12-member ring motif. A faster dissolution rate for both drugs was achieved through the salt combination compared to the individual drugs in an aqueous acidic medium. The dissolution rate exhibited a peak concentration (Cmax) of approximately 310 mg cm−2 min−1 for PAN and 240 mg cm−2 min−1 for DBF at a Tmax of less than 20 min under gastric pH 1.2 (0.1 N HCl) compared to the pure drug dissolution values of 10 and 80 mg cm−2 min−1, respectively. The novel and fast-dissolving salt DBF−·PAN+ was analyzed in BRAFV600E melanoma cells Sk-Mel28. DBF−·PAN+ reduced the dose−response from micromolar to nanomolar concentrations and lowered IC50 (21.9 ± 7.2 nM) by half compared to PAN alone (45.3 ± 12.0 nM). The enhanced dissolution and lower survival rate of melanoma cells show the potential of novel DBF−·PAN+ salt in clinical evaluation

Automatic dysarthria detection and severity level assessment using CWT-layered CNN model

Abstract Dysarthria is a speech disorder that affects the ability to communicate due to articulation difficulties. This research proposes a novel method for automatic dysarthria detection (ADD) and automatic dysarthria severity level assessment (ADSLA) by using a variable continuous wavelet transform (CWT) layered convolutional neural network (CNN) model. To determine their efficiency, the proposed model is assessed using two distinct corpora, TORGO and UA-Speech, comprising both dysarthria patients and healthy subject speech signals. The research study explores the effectiveness of CWT-layered CNN models that employ different wavelets such as Amor, Morse, and Bump. The study aims to analyze the models’ performance without the need for feature extraction, which could provide deeper insights into the effectiveness of the models in processing complex data. Also, raw waveform modeling preserves the original signal’s integrity and nuance, making it ideal for applications like speech recognition, signal processing, and image processing. Extensive analysis and experimentation have revealed that the Amor wavelet surpasses the Morse and Bump wavelets in accurately representing signal characteristics. The Amor wavelet outperforms the others in terms of signal reconstruction fidelity, noise suppression capabilities, and feature extraction accuracy. The proposed CWT-layered CNN model emphasizes the importance of selecting the appropriate wavelet for signal-processing tasks. The Amor wavelet is a reliable and precise choice for applications. The UA-Speech dataset is crucial for more accurate dysarthria classification. Advanced deep learning techniques can simplify early intervention measures and expedite the diagnosis process

Towards real-time heartbeat classification : evaluation of nonlinear morphological features and voting method

Abnormal heart rhythms are one of the significant health concerns worldwide. The current state-of-the-art to recognize and classify abnormal heartbeats is manually performed by visual inspection by an expert practitioner. This is not just a tedious task; it is also error prone and, because it is performed, post-recordings may add unnecessary delay to the care. The real key to the fight to cardiac diseases is real-time detection that triggers prompt action. The biggest hurdle to real-time detection is represented by the rare occurrences of abnormal heartbeats and even more are some rare typologies that are not fully represented in signal datasets; the latter is what makes it difficult for doctors and algorithms to recognize them. This work presents an automated heartbeat classification based on nonlinear morphological features and a voting scheme suitable for rare heartbeat morphologies. Although the algorithm is designed and tested on a computer, it is intended ultimately to run on a portable i.e., field-programmable gate array (FPGA) devices. Our algorithm tested on Massachusetts Institute of Technology-Beth Israel Hospital(MIT-BIH) database as per Association for the Advancement of Medical Instrumentation(AAMI) recommendations. The simulation results show the superiority of the proposed method, especially in predicting minority groups: the fusion and unknown classes with 90.4% and 100%