Segmented waveguides in thin silicon-on-insulator

We have developed new silicon-on-insulator waveguide designs for simultaneously achieving both low-loss optical confinement and electrical contacts, and we present a design methodology based on calculating the Bloch modes of such segmented waveguides. With this formalism, waveguides are designed in a single thin layer of silicon-on-insulator to achieve both optical confinement and minimal insertion loss. Waveguides were also fabricated and tested, and the measured data were found to closely agree with theoretical predictions, demonstrating input insertion loss and propagation loss better than 0.1 dB and -16 dB/cm, respectively

Does science need computer science?

IBM Hursley Talks Series 3An afternoon of talks, to be held on Wednesday March 10 from 2:30pm in Bldg 35 Lecture Room A, arranged by the School of Chemistry in conjunction with IBM Hursley and the Combechem e-Science Project.The talks are aimed at science students (undergraduate and post-graduate) from across the faculty. This is the third series of talks we have organized, but the first time we have put them together in an afternoon. The talks are general in nature and knowledge of computer science is certainly not necessary. After the talks there will be an opportunity for a discussion with the lecturers from IBM.Does Science Need Computer Science?Chair and Moderator - Jeremy Frey, School of Chemistry.- 14:00 "Computer games for fun and profit" (*) - Andrew Reynolds - 14:45 "Anyone for tennis? The science behind WIBMledon" (*) - Matt Roberts - 15:30 Tea (Chemistry Foyer, Bldg 29 opposite bldg 35) - 15:45 "Disk Drive physics from grandmothers to gigabytes" (*) - Steve Legg - 16:35 "What could happen to your data?" (*) - Nick Jones - 17:20 Panel Session, comprising the four IBM speakers and May Glover-Gunn (IBM) - 18:00 Receptio

The Stellar Halos of Massive Elliptical Galaxies II: Detailed Abundance Ratios at Large Radius

We study the radial dependence in stellar populations of 33 nearby early-type galaxies with central stellar velocity dispersions sigma* > 150 km/s. We measure stellar population properties in composite spectra, and use ratios of these composites to highlight the largest spectral changes as a function of radius. Based on stellar population modeling, the typical star at 2 R_e is old (~10 Gyr), relatively metal poor ([Fe/H] -0.5), and alpha-enhanced ([Mg/Fe]~0.3). The stars were made rapidly at z~1.5-2 in shallow potential wells. Declining radial gradients in [C/Fe], which follow [Fe/H], also arise from rapid star formation timescales due to declining carbon yields from low-metallicity massive stars. In contrast, [N/Fe] remains high at large radius. Stars at large radius have different abundance ratio patterns from stars in the center of any present-day galaxy, but are similar to Milky Way thick disk stars. Our observations are thus consistent with a picture in which the stellar outskirts are built up through minor mergers with disky galaxies whose star formation is truncated early (z~1.5-2).Comment: ApJ in press, 12 pages, 6 figure

Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential

To characterize the repair pathways of chromosome double-strand breaks (DSBs), one approach involves monitoring the repair of site-specific DSBs generated by rare-cutting endonucleases, such as I-SceI. Using this method, we first describe the roles of Ercc1, Msh2, Nbs1, Xrcc4, and Brca1 in a set of distinct repair events. Subsequently, we considered that the outcome of such assays could be influenced by the persistent nature of I-SceI-induced DSBs, in that end-joining (EJ) products that restore the I-SceI site are prone to repeated cutting. To address this aspect of repair, we modified I-SceI-induced DSBs by co-expressing I-SceI with a non-processive 3′ exonuclease, Trex2, which we predicted would cause partial degradation of I-SceI 3′ overhangs. We find that Trex2 expression facilitates the formation of I-SceI-resistant EJ products, which reduces the potential for repeated cutting by I-SceI and, hence, limits the persistence of I-SceI-induced DSBs. Using this approach, we find that Trex2 expression causes a significant reduction in the frequency of repair pathways that result in substantial deletion mutations: EJ between distal ends of two tandem DSBs, single-strand annealing, and alternative-NHEJ. In contrast, Trex2 expression does not inhibit homology-directed repair. These results indicate that limiting the persistence of a DSB causes a reduction in the frequency of repair pathways that lead to significant genetic loss. Furthermore, we find that individual genetic factors play distinct roles during repair of non-cohesive DSB ends that are generated via co-expression of I-SceI with Trex2

Neurosteroids and GABAA Receptor Interactions: A Focus on Stress

Since the pioneering discovery of the rapid CNS depressant actions of steroids by the “father of stress,” Hans Seyle 70 years ago, brain-derived “neurosteroids” have emerged as powerful endogenous modulators of neuronal excitability. The majority of the intervening research has focused on a class of naturally occurring steroids that are metabolites of progesterone and deoxycorticosterone, which act in a non-genomic manner to selectively augment signals mediated by the main inhibitory receptor in the CNS, the GABAA receptor. Abnormal levels of such neurosteroids associate with a variety of neurological and psychiatric disorders, suggesting that they serve important physiological and pathophysiological roles. A compelling case can be made to implicate neurosteroids in stress-related disturbances. Here we will critically appraise how brain-derived neurosteroids may impact on the stress response to acute and chronic challenges, both pre- and postnatally through to adulthood. The pathological implications of such actions in the development of psychiatric disturbances will be discussed, with an emphasis on the therapeutic potential of neurosteroids for the treatment of stress-associated disorders