58 research outputs found

    STABILITY INDICATING RP-HPLC ASSAY METHOD FOR ESTIMATION OF DIMETHYL FUMARATE IN BULK AND CAPSULES

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    Objective: To develop an accurate, simple, precise and specific stability indicating RP-HPLC method for estimation of dimethyl fumarate in bulk and capsules.Methods: An Inertsil ODS (150x4.6 mm, 5µ) column and a mobile phase containing acetonitrile: potassium dihydrogen phosphate buffer pH 6.8 (50:50% v/v) was used for this study. The flow rate was maintained at 1.0 ml/min; column temperature was fixed at 35 °C and UV detection was carried out at 210 nm. The forced degradation studies were performed and method was validated with as per ICH guidelines.Results: The retention time of dimethyl fumarate was found to be 3.3±0.02 min. The value of correlation coefficient between peak area and concentration was found to be 0.9993. The mean percent recovery of dimethyl fumarate in capsules was found in the range of 99.65 to 101.64%. The results of forced degradation studies indicated that the drug was found to be stable in basic, oxidative and thermal conditions while degraded in acidic conditions.Conclusion: It can be conducted from results that the developed HPLC method is simple, accurate, precise and specific. Results of stress testing study revealed that the method is stability indicating. Thus, this method can be used for routine analysis of dimethyl fumarate capsules and check their stability. Â

    A Hepta-band Antenna Loaded with E-shaped Slot for S/C/X-band Applications

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    A compact planar multiband antenna operating at 3.1 (S-band) /4.7/6.4/7.6 (C-band) /8.9/10.4/11.8 GHz (X-band) is presented. The proposed Microstrip Patch Antenna (MSPA) consists of a rectangular radiator in which an E-shaped slot is etched out and a microstrip feed line. The E-shaped slot modifies the total current path thereby making the antenna to operate at seven useful bands. No external impedance matching circuit is used and the impedance matching at these bands are solely achieved by using a rectangular microstrip feed line of length 10mm (L6) and width 2mm (W10). The antenna has a compact dimension of and exhibits S11<-10dB bandwidth of about 6.45% (3.2-3.0GHz), 8.5% (4.9-4.5GHz), 7.6% (6.7-6.2GHz), 3.9% (7.8-7.5GHz), 5.7% (9.1-8.6GHz), 1.2% (10.44-10.35GHz) and 2.2% (11.87-11.62GHz). The simulation analysis of the antenna is carried out by using HFSS v.13.

    Resolvins suppress tumor growth and enhance cancer therapy

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    National Cancer Institute grants RO1 01CA170549-02 (to D. Panigrahy and C.N. Serhan), ROCA148633-01A4 (to D. Panigrahy), and GM095467 (to C.N. Serhan); the Stop and Shop Pediatric Brain Tumor Fund (to M.W. Kieran); the CJ Buckley Pediatric Brain Tumor Fund (to M.W. Kieran); Alex Lemonade Stand (to M.W. Kieran); Molly’s Magic Wand for Pediatric Brain Tumors (to M.W. Kieran); the Markoff Foundation Art-In-Giving Foundation (to M.W. Kieran); the Kamen Foundation (to M.W. Kieran); Jared Branfman Sunflowers for Life (to M.W.K.); and The Wellcome Trust program 086867/Z/08 (to M. Perretti)

    Adoption of new technologies in Ethiopian agriculture: The case of Tegulet-Bulga District, Shoa province

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    Demonstrates how the various economic, social, and physical variables and degree of risk aversion affect the adoption of three selected technologies, viz, single-ox, fertilizer, and pesticide, in Ethiopian agriculture. Discusses characteristics of these technologies and factors that motivated farmers to use or not to use these production technologies. Also looks into how sequential decisions are implemented. The factors include models of adoption behaviour, empirical model specification - specified as a function of economic, social and physical factors, risk and adoption of technologies, and predicted probabilities. Also looks into how sequential decisions are implemented

    8-Amino-2'-deoxyadenosine:2'-deoxythymidine base pairing: identification of novel reverse Hoogsteen mode in solution

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    A novel reversed Hoogsteen mode is observed for the base-pairing of 8-amino-2'-deoxyadenosine with 2'-deoxythymidine in low dielectric solvent. The results may have important significance for designing novel DNA duplexes and triplexes incorporating 8-amino-dA
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