Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload

The use of histone deacetylase (HDAC) inhibitor is a novel therapeutic strategy for cardiovascular disease. Studies have shown that many HDAC inhibitors have the ability to reduce the aortic remodeling in various animal models. We hypothesized that the HDAC inhibitor, MGCD0103 (MGCD), attenuates aortic remodeling in rats under pressure overload-induced by transverse aortic constriction (TAC). The aortic ring tension analysis was conducted using the thoracic aorta. Sections of the aorta were visualized after hematoxylin and eosin, trichrome, and Verhoeff-van Gieson staining, and immunohistochemistry. The expression of genes related to aortic remodeling (αSMA, Mmp2, and Mmp9) and angiotensin receptors (Agtr1 and Agtr2) was determined by quantitative real-time polymerase chain reaction. There was a significant decrease in relaxation of the aorta when treated with MGCD. Fibrosis of the aortic wall and expression of angiotensin receptors increased in TAC rats, which was attenuated by MGCD. These results indicate that MGCD, an HDAC inhibitor, attenuates aortic remodeling in rats with TAC-induced pressure overload rats and may serve as a potential therapeutic target of antiaortic remodeling in pressure overload-induced hypertension-related diseases

Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung

Background and Objectives: Telomeric zinc finger-associated protein (TZAP) is a telomere regulation protein, previously known as ZBTB48. It binds preferentially to elongated telomeres, competing with telomeric repeat factors 1 and 2. TZAP expression may be associated with carcinogenesis, however; this study has not yet been performed in lung cancer. In this study, we examined the clinicopathological and prognostic values of TZAP expression in non-small cell lung cancer (NSCLC). Materials and Methods: Data were collected from The Cancer Genome Atlas. The clinical and prognostic values of TZAP for NSCLC were examined in adenocarcinoma (AD) and squamous cell carcinoma (SCC). Results: TZAP expression significantly increased in NSCLC tissues compared with normal tissues. In AD, TZAP expression was lower in patients with higher T stage (p = 0.005), and was associated with lymph node stage in SCC (p = 0.005). Survival analysis showed shorter disease-free survival in AD patients with lower TZAP expression (p = 0.047). TZAP expression did not have other clinical or prognostic value for AD and SCC. Conclusions: TZAP expression is a potential prognostic marker for NSCLC, especially in patients with AD

Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung

Background and Objectives: Telomeric zinc finger-associated protein (TZAP) is a telomere regulation protein, previously known as ZBTB48. It binds preferentially to elongated telomeres, competing with telomeric repeat factors 1 and 2. TZAP expression may be associated with carcinogenesis, however; this study has not yet been performed in lung cancer. In this study, we examined the clinicopathological and prognostic values of TZAP expression in non-small cell lung cancer (NSCLC). Materials and Methods: Data were collected from The Cancer Genome Atlas. The clinical and prognostic values of TZAP for NSCLC were examined in adenocarcinoma (AD) and squamous cell carcinoma (SCC). Results: TZAP expression significantly increased in NSCLC tissues compared with normal tissues. In AD, TZAP expression was lower in patients with higher T stage (p = 0.005), and was associated with lymph node stage in SCC (p = 0.005). Survival analysis showed shorter disease-free survival in AD patients with lower TZAP expression (p = 0.047). TZAP expression did not have other clinical or prognostic value for AD and SCC. Conclusions: TZAP expression is a potential prognostic marker for NSCLC, especially in patients with AD

Non-Anastomotic Rupture of a Woven Dacron Graft in the Descending Thoracic Aorta Treated with Endovascular Stent Grafting

The intrinsic structural failure of a Dacron graft resulting from the loss of structural integrity of the graft fabric can cause late graft complications. Late non-anastomotic rupture has traditionally been treated surgically via open thoracotomy. We report a case of the successful use of thoracic endovascular repair to treat a Dacron graft rupture in the descending aorta. The rupture occurred 20 years after the graft had been placed. Two stent grafts were placed at the proximal portion of the surgical graft, covering almost its entire length

Design, Performance Evaluation and Field Test of a Water Jet Tool for ROV Trencher

ROV trencher is a kind of ROV which trenches the sea floor using a specifically designed tool and buries the subsea cables and pipelines. According to the soil conditions, this trenching method can have two different types, one is mechanical cutting and the other one is water jetting. In this paper, we present a water jet tool design method for a 2500 m depth-rated ROV trencher. A series of CFD simulations and laboratory tests with one nozzle, and a ground test using 1:6 scale jetting arm model were carried out to derive and demonstrate the jetting tool design parameters. In October 2018, the constructed ROV trencher was put into the sea trial in the East Sea of Korea to evaluate its final performances. In addition, in December 2019, the trencher was applied in a construction site to bury subsea water pipelines near the Yogji Island in the Korea. Through these two field tests and operation, the trencher was demonstrated for both its operational capability and trenching performance. The main contribution of this paper is that it presents the entire design procedures of water jet tools, including CFD simulations, laboratory tests, field test with 1:6 scaled jetting tool, and the final prototype tool design. These consecutive procedures are carried out in order for us to set up sort of relationship between jetting angle, trench depth, trench speed, and jetting power, from which we can predict and evaluate the trenching performance of the prototype jetting tool

Design, Performance Evaluation and Field Test of a Water Jet Tool for ROV Trencher

ROV trencher is a kind of ROV which trenches the sea floor using a specifically designed tool and buries the subsea cables and pipelines. According to the soil conditions, this trenching method can have two different types, one is mechanical cutting and the other one is water jetting. In this paper, we present a water jet tool design method for a 2500 m depth-rated ROV trencher. A series of CFD simulations and laboratory tests with one nozzle, and a ground test using 1:6 scale jetting arm model were carried out to derive and demonstrate the jetting tool design parameters. In October 2018, the constructed ROV trencher was put into the sea trial in the East Sea of Korea to evaluate its final performances. In addition, in December 2019, the trencher was applied in a construction site to bury subsea water pipelines near the Yogji Island in the Korea. Through these two field tests and operation, the trencher was demonstrated for both its operational capability and trenching performance. The main contribution of this paper is that it presents the entire design procedures of water jet tools, including CFD simulations, laboratory tests, field test with 1:6 scaled jetting tool, and the final prototype tool design. These consecutive procedures are carried out in order for us to set up sort of relationship between jetting angle, trench depth, trench speed, and jetting power, from which we can predict and evaluate the trenching performance of the prototype jetting tool

UUV Simulation Modeling and its Control Method: Simulation and Experimental Studies

This paper presents the development of an unmanned underwater vehicle (UUV) platform, especially the derivation of the vehicle’s simulation model and its control method to overcome strong sea current. The platform is designed to have a flattened ellipsoidal exterior so as to minimize the hydrodynamic damping on the horizontal plane. Four horizontal thrusters with the identical specifications are symmetrically mounted on the horizontal plane, and each of them has the same thrust dynamics in both forward and reverse directions. In addition, there are three vertical thrusters used to handle the vehicle’s roll, pitch and heave motions. Control strategy proposed in this paper to overcome strong current is that: maximizing the vectored horizontal thrust force against the sea current without or with the least of the vehicle’s rotation on the horizontal plane. For the vehicle model, due to it being symmetric in all of three axes, the vehicle dynamics can be simplified and all of hydrodynamic coefficients are calculated through both of theoretical and empirically-derived formulas. Numerical simulations and experimental studies in both of the water tank and the circulating water channel are carried out to demonstrate the vehicle’s capability of overcoming strong current