A CASE OF RARE CONGENITAL HEART MALFORMATION: TAUSSIG- BING SYNDROME

Introduction- Taussig- Bing Syndrome is a rare congenital heart malformation that was first described by Helen Taussig and Richard Bing. The aim of this article is to show the main morphological changes in this case of rare congenital malformation. Performed methods were autopsy examination, clinical data analysis, x-ray examination and microscopic examination. Results- the index case is 34 days- old male newborn, born in 37 gestational age, with weight 2.150gr. and height- 45 cm. The heart was found enlarged with normal position in the chest. During dissection of the heart there were detected: hypertrophy and dilation of the right ventricle; the aorta arise entirely above the right ventricle; the dilated pulmonary valve does not override the left ventricular cavity; pulmonary artery arises primarily from the right ventricle and partially overrides the ventricular septum and a high and large sub- pulmonary ventricular septal defect. Conclusions- The treatment of this syndrome is continuing to be an actual medical problem. The right diagnose and the adequate treatment can widely reduce the mortality and morbidity from this disease

Child abuse syndrome – a forensic case of fatal impulsive act of violence

Child abuse syndrome is a medico-social problem widely spread around the world, which includes a complex of clinically manifested forms of violence against children. This syndrome includes different forms of physical violence, sexual violence, neglect, and emotional violence against children. The main problem with this type of violence continues to be the large number of unregistered “hidden” cases. The consequences of violence against children are serious and have a lasting negative effect on the physical and mental health of the victims. Child abuse is often a result of impulsive violent behavior with minimal provocation and may have a fatal outcome. We present a case of a 3-year-old boy, admitted to the Emergency Department of the Municipal Hospital in Asenovgrad, Bulgaria, in a state of biological death. Case circumstances during the police investigation were unclear and the body was transported for forensic examination. During the forensic autopsy, many traumatic injuries were observed over the whole body – bruises of different ages, fractures of bones, abdominal trauma with bucket-handle tear of the mesentery, thoracic trauma with contusions and ruptures of the lungs, rupture of the diaphragm, and many other injuries that are specific predictors for this type of child physical abuse. The main aim of the present report is to enrich the knowledge of medical workers in their routine practical work in the identification and determination of child abuse syndrome. It could prevent the fatal outcome and reduce the mortality from this specific type of violence

Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review

Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. In this narrative review, we focus on endothelial dysfunction (ED) in pregnancy, associated with obstetric complications, such as preeclampsia, fetal growth retardation, gestational diabetes, etc., and SARS-CoV-2 infection in pregnant women that can cause ED itself and overlap with other pregnancy complications. We also discuss some shared mechanisms of SARS-CoV-2 pathophysiology and ED