Matching of the Heavy-Light Currents with NRQCD Heavy and Improved Naive Light Quarks

One-loop matching of heavy-light currents is carried out for a highly improved lattice action, including the effects of mixings with dimension 4 O(1/M) and O(a) operators. We use the NRQCD action for heavy quarks, the Asqtad improved naive action for light quarks, and the Symanzik improved glue action. These results are being used in recent heavy meson decay constant and semileptonic form factor calculations on the MILC dynamical configurations.Comment: 3 pages, 3 figures. Talk presented at Lattice2004(heavy

B Leptonic Decays and B- bar B Mixing with 2+1 Flavors of Dynamical Quarks

Calculations of B leptonic decays and B- bar B mixing using NRQCD heavy and Asqtad light valence quarks on the MILC dynamical configurations are described. Smearing has been implemented to substantially reduce the statistical errors of the matrix elements needed for the determination of f_B. The four-fermion matrix elements needed for the determination of f_{B_s}^2B_{B_s} have been calculated and a preliminary result is given.Comment: 3 pages, 3 figures, talk given at Lattice2004(heavy), Batavia, Illinois, 21-26 Jun 200

Heavy-Light Meson Semileptonic Decays with Staggered Light Quarks

We report on exploratory studies of heavy-light meson semileptonic decays using Asqtad light quarks, NRQCD heavy quarks and Symanzik improved glue on coarse quenched lattices. Oscillatory contributions to three-point correlators coming from the staggered light quarks are found to be handled well by Bayesian fitting methods. B meson decays to both the Goldstone pion and to one of the point-split non-Goldstone pions are investigated. One-loop perturbative matching of NRQCD/Asqtad heavy-light currents is incorporated.Comment: 3 pages, 3 postscript figures, Lattice2003(heavy

The B Meson Decay Constant from Unquenched Lattice QCD

We present determinations of the B meson decay constant f_B and of the ratio f_{B_s}/f_B using the MILC collaboration unquenched gauge configurations which include three flavors of light sea quarks. The mass of one of the sea quarks is kept around the strange quark mass, and we explore a range in masses for the two lighter sea quarks down to m_s/8. The heavy b quark is simulated using Nonrelativistic QCD, and both the valence and sea light quarks are represented by the highly improved (AsqTad) staggered quark action. The good chiral properties of the latter action allow for a much smoother chiral extrapolation to physical up and down quarks than has been possible in the past. We find f_B = 216(9)(19)(4) (6) MeV and f_{B_s} /f_B = 1.20(3)(1).Comment: 4 pages, 2 figure

The Upsilon spectrum and m_b from full lattice QCD

We show results for the Upsilon spectrum calculated in lattice QCD including for the first time vacuum polarization effects for light u and d quarks as well as s quarks. We use gluon field configurations generated by the MILC collaboration. The calculations compare the results for a variety of u and d quark masses, as well as making a comparison to quenched results (in which quark vacuum polarisation is ignored) and results with only u and d quarks. The b quarks in the Upsilon are treated in lattice Nonrelativistic QCD through NLO in an expansion in the velocity of the b quark. We concentrate on accurate results for orbital and radial splittings where we see clear agreement with experiment once u, d and s quark vacuum polarisation effects are included. This now allows a consistent determination of the parameters of QCD. We demonstrate this consistency through the agreement of the Upsilon and B spectrum using the same lattice bare b quark mass. A one-loop matching to continuum QCD gives a value for the b quark mass in full lattice QCD for the first time. We obtain m_b^{\bar{MS}}(m_b^{\bar{MS}}) = 4.4(3) GeV. We are able to give physical results for the heavy quark potential parameters, r_0 = 0.469(7) fm and r_1 = 0.321(5) fm. Results for the fine structure in the spectrum and the Upsilon leptonic width are also presented. We predict the Upsilon - eta_b splitting to be 61(14) MeV, the Upsilon^{\prime} - eta_b^{\prime} splitting as 30(19) MeV and the splitting between the h_b and the spin-average of the chi_b states to be less than 6 MeV. Improvements to these calculations that will be made in the near future are discussed.Comment: 24 pages, 19 figures. Version to be published. Minor changes made and typographical errors corrected. Experimental leptonic widths updated in section

Precision lattice QCD calculations and predictions of fundamental physics in heavy quark systems

I describe the recent success in performing accurate calculations of the effects of the strong force on particles containing bottom and charm quarks. Since quarks are never seen in isolation, and so cannot be studied directly, numerical simulations are key to understanding the properties of these particles and extracting information about the quarks. The results have direct impact on the worldwide experimental programme that is aiming to determine the parameters of the Standard Model of particle physics precisely and thereby uncover or constrain the possibilities for physics beyond the Standard Model. The numerical simulation of the strong force is a huge computational task and the recent success is the result of international collaboration in developing techniques that are fast enough to do the calculations on powerful supercomputers.Comment: Invited talk at SCIDAC 2006, Denver, June 2006. 15 page

Granulomatous pyoderma preceding chronic recurrent multifocal osteomyelitis triggered by vaccinations in a two-year-old boy: a case report

<p>Abstract</p> <p>Introduction</p> <p>Chronic recurrent multifocal osteomyelitis is a rare, systemic, aseptic, inflammatory disorder that involves different sites. Pathogenesis of chronic recurrent multifocal osteomyelitis is currently unknown.</p> <p>Case presentation</p> <p>A two-year-old Caucasian boy, diagnosed with chronic recurrent multifocal osteomyelitis with granulomatous pyoderma following routine vaccinations is presented for the first time in the literature.</p> <p>Conclusion</p> <p>We conclude that antigen exposures might have provoked this inflammatory condition for our case. Skin and/or bone lesions following vaccinations should raise suspicion of an inflammatory response such as chronic recurrent multifocal osteomyelitis only after thorough evaluation for chronic infection, autoimmune, immunodeficiency or vasculitic diseases.</p

Consensus Middle East and North Africa Registry on Inborn Errors of Immunity

Background: Inborn errors of immunity (IEIs) are a heterogeneous group of genetic defects of immunity, which cause high rates of morbidity and mortality mainly among children due to infectious and non-infectious complications. The IEI burden has been critically underestimated in countries from middle- and low-income regions and the majority of patients with IEI in these regions lack a molecular diagnosis. Methods: We analyzed the clinical, immunologic, and genetic data of IEI patients from 22 countries in the Middle East and North Africa (MENA) region. The data was collected from national registries and diverse databases such as the Asian Pacific Society for Immunodeficiencies (APSID) registry, African Society for Immunodeficiencies (ASID) registry, Jeffrey Modell Foundation (JMF) registry, J Project centers, and International Consortium on Immune Deficiency (ICID) centers. Results: We identified 17,120 patients with IEI, among which females represented 39.4%. Parental consanguinity was present in 60.5% of cases and 27.3% of the patients were from families with a confirmed previous family history of IEI. The median age of patients at the onset of disease was 36 months and the median delay in diagnosis was 41 months. The rate of registered IEI patients ranges between 0.02 and 7.58 per 100,000 population, and the lowest rates were in countries with the highest rates of disability-adjusted life years (DALY) and death rates for children. Predominantly antibody deficiencies were the most frequent IEI entities diagnosed in 41.2% of the cohort. Among 5871 patients genetically evaluated, the diagnostic yield was 83% with the majority (65.2%) having autosomal recessive defects. The mortality rate was the highest in patients with non-syndromic combined immunodeficiency (51.7%, median age: 3.5 years) and particularly in patients with mutations in specific genes associated with this phenotype (RFXANK, RAG1, and IL2RG). Conclusions: This comprehensive registry highlights the importance of a detailed investigation of IEI patients in the MENA region. The high yield of genetic diagnosis of IEI in this region has important implications for prevention, prognosis, treatment, and resource allocation

Ketamine and midazolam for invasive procedures in children with malignancy: A comparison of routes of intravenous, oral, and rectal administration

PubMed ID: 15357562We investigated the efficacy of a combination of ketamine and midazolam, comparing intravenous, oral, and rectal administrations for invasive procedures in children with malignancy. Seventy-three children under 5 years of age, who were scheduled for invasive procedure, were assigned to one of three groups: IV group (n = 25), ketamine 1 mg/kg and midazolam 0.05-0.1 mg/kg were given intravenously; PO group (n = 24), ketamine 3 mg/kg and midazolam 0.5 mg/kg were given orally; and PR group (n = 24), ketamine 3 mg/kg and midazolam 0.5 mg/kg given rectally. Vital signs including blood pressure, pulse rate, respiratory rate, and oxygen saturation were monitored, and patients were observed for side-effects. Optimal sedation (drowsy and asleep) was provided in 78 per cent of all patients and no statistical difference was observed among the three groups. No severe complications were observed in all groups. Recovery time from sedation was significantly longer in the intravenous group (>120 min in two patients). Hallucination was noted in three (12 per cent) patients given intravenous medication, but not in those given oral or rectal medications. It is concluded that intravenous, oral, and rectal midazolam/ketamine are equally effective for invasive procedures in children with malignancy. The use of intravenous ketamine/midazolam may produce prolonged sedation and psychedelic effects in children. These adverse effects may alter the child's comfort and parental satisfaction. © Oxford University Press 2004; all rights reserved